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Showing 1 to 1 of 1 for “"MIP-box–MLH1 interaction"”.
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New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… interacts with the mismatch repair (MMR) protein MLH1, which, together with MLH3, is indispensable for CAG repeat expansion in HD. Here, I show that FAN1 interacts with MLH1 via a well conserved MLH1- interacting peptide motif (MIP-box) on FAN1, which is necessary for FAN1-MLH1 interaction. I …