Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"MIP-2"”.
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Stat3 Controls The Neutrophil Migratory Response to Cxcr2 and Its Ligand Mip-2 (Cxcl2)
… was unknown. The chemokines KC (Cxcl1) and MIP-2 (Cxcl2), and their shared receptor CXCR2 (l8rb), also stimulate neutrophil mobilization, in contrast to SDF-1 (Cxcl12), which contributes to neutrophil retention in the bone marrow, requiring downregulation to promote neutrophil release. Using …
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Investigation of chemokine expression and modulation following traumatic brain injury
… chemokine, macrophage inflammatory protein-2 (MIP-2/CXCL2) and the monocytic chemokine, monocyte chemoattractant protein-1 (MCP-1/CCL2) are derived from glial. However the origin of these chemokines following TBI, has not been established. Furthermore, little is known about the modulation of …
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On the role of mast cells in chemokine-induced leukocyte recruitment
… cells to express P-selectin and CXC chemokine (MIP-2) and cause leukocyte adhesion in vitro in a glucocorticoid-sensitive manner. Interestingly, chemokines, both MIP-Ialpha, MCP-I and MIP-2, KC, were found to provoke a dose-dependent increase in P-selectin-dependent leukocyte roUing, adhesion …
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Roles of CCAAT/enhancer-binding protein [beta] and [-delta] in immunoglobulin G immune complex-induced Inflammation
… (TNF-&alpha), macrophage inflammatory protein-2 (MIP-2), and macrophage inflammatory protein-1&alpha (MIP-1&alpha) in IgG IC-stimulated macrophages. Moreover, both extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen activated protein kinase (MAPK) were involved in C/EBP induction …
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Macrophages in vitro as a predictive model in polymer toxicology
… (TNFα) and macrophage inflammatory protein-2 (MIP-2) levels were significantly increased following instillation of Polymer 3 and Minusil. Thus the polymers and particles were ranked for potential to cause pulmonary inflammation: Polymer 3 > Minusil > Polymer 1 > Polymer 2 > TiO2. In vitro …
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Characterization of VIBRIO Parahaemolyticus-Induced Intestinal Inflammation in the Mouse
… cytokines IL-1? and IFN-gamma and chemokines KC, MIP-2 alpha, and CXCL-9 reveals that the duration of the inflammatory response is extended in the presence of TDH. In addition to delineating the roles of the virulence factors TDH, type III secretion system 1, and type III secretion system 2, in …
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The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function
… the increased production of IL-6, IL-12p40 and MIP-2. These DCs were capable of inducing Th2 responses. Overall the data suggests that helminth parasites secrete multiple molecules each possessing a unique mechanism of modulation, which can either suppress inflammatory Th1/Th17 responses or …
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Defensins In Ocular Immunity
… <p>pro-inflammatory molecules (e.g., IFN-gamma, MIP-2, IL-1beta, TNF-alpha), iNOS, as well as TLR signaling molecules (e.g., TLR2, TLR4, MyD88) and transcription factor NF-kappaB. Most</p> <p>notably, bacterial load was increased at 5 days p.i. by silencing either mBD2 or mBD3,</p> <p>but was …
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Functional Characterisation of a Novel Tir-Domain containing Protein in Immune Signalling
… MAPK and expression of the neutrophil chemokine MIP-2. In contrast, IL-17RD deficiency results in enhanced IL-17A-induced activation of NF-κB and IL-6 and KC expression. IL-17RD disrupts the interaction of Act1 and TRAF6 causing differential regulation of NF-κB and p38 MAPK signalling pathways.
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Mechanisms of neutrophil recruitment in septic lung injury
… neutrophil infiltration, and increased levels of MIP-2 in the lung. We demonstrate that immunoneutralization with anti-CD44 reduce neutrophil activation and accumulation as well as edema formation and lung injury. Pretreatment with Y-27632 reduced the CLP-induced pulmonary injury and MPO activity …
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Role of the NLRP3 Inflammasome in bacterial keratitis
… response, neutrophil numbers, and IL-1β, IL-17A, MIP-2 after treatment with MCC950 or MCC950 + gentamicin 24 and 72 hours after infection. In contrast, BALB/c mice infected with S. aureus and C57BL/6 mice did not show a significant improvement (p>0.05) in clinical outcome after treatment. …
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The Role Of Inflammation In Pathogenesis And Treatment Of Globoid-Cell Leukodystrophy
… in other cytokines and growth factors like MIP-2, FGF-2 and PDGF-BB. Although, KC and CXCR2 probably exert their effects in combination with other cytokines and growth factors, inflammation is clearly an important player in the pathogenesis and treatment of Krabbe's disease, but targeting …
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Melioidis: an investigation of cellular immune responses
… (KC), macrophage inflammatory protein-2 (MIP-2), granulocyte colony-stimulating factor (G-CSF), macrophage (M)-CSF, granulocyte-macrophage (GM)-CSF during infection with a highly virulent strain of B. pseudomallei (NCTC 13178). Histological changes and bacterial loads were also monitored …
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Untersuchungen zur Inhibierung der Expression der Poly(ADP-ribose)Polymerase (PARP) nach Infektion mit Toxoplasma gondii
… an der parasiten-vermittelten Verminderung von MIP-2, nicht aber jener von TNF-α beteiligt zu sein schien. Die PARP-1-Inhibierung durch T. gondii könnte daher ein bisher unbekannter Mechanismus des Parasiten sein, in pro-inflammatorische Chemokin-vermittelte Abwehrmechanismen der Wirtszelle …
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Crosstalk between Inflammation and Coagulation in Acute Pancreatitis - Experimental and Clinical Studies.
In various inflammatory conditions a close interplay between inflammation and coagulation is known to exist, where coagulation factor VII (FVII) and tissue factor (TF) are considered to be pivotal players. In this thesis the crosstalk between inflammation and coagulation in acute pancreatitis (AP) …