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Showing 1 to 20 of 40 for “"MIF"”.
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Molekulare Steuerung des Mamma-Karzinom-Verhaltens durch das inflammatorische Zytokin MIF
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine and mediator of acute and chronic inflammatory diseases. MIF is overexpressed in various tumours and has been suggested as a molecular link between chronic inflammation and cancer. In the context of the present study we …
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Molecular mechanisms of the unconventional secretion of macrophage migration inhibitory factor (MIF)
… shock and rheumatoid arthritis. The release of MIF from inflammatory cells is a common feature in these diseases, and a correlation between the severity of disease and MIF production is observed. MIF is a leaderless protein that is secreted from cells by a specialized, non-classical export …
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Functional Characterization of the Avian Inflammatory Mediators Nod1, MIF and IL-22
… macrophage migration inhibitory factor (MIF) inhibits the random migration of macrophages. Chemotaxis assay using recombinant ChMIF (rChMIF) revealed a substantial decrease in migration of macrophages. qRT-PCR analysis revealed that the presence of rChMIF enhanced levels of IL-1β and iNOS …
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Der Einfluss von HtrA2/Omi auf AIFM1 und MIF in der Zelltodmodalität Parthanatos
… gilt die Kerntranslokation von AIFM1 und MIF als charakteristisch. Weiß et al. hatten beschrieben, dass Zellen, denen die mitochondriale Serinprotease HtrA2/Omi fehlt, weniger anfällig für den Tod durch Parthanatos sind. Daher beschäftigt sich die vorliegende Arbeit mit der Frage, ob der …
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Dissecting the impact of macrophage migration inhibitory factor (MIF) on host immune response
Macrophage migration inhibitory factor (MIF) has been implicated in mediating both innate and adaptive immune responses in inflammatory and infectious diseases. The sequence and structure of MIF is highly conserved across the avian phylogeny, which underlies high sequence homology and functional …
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Antiapoptotische Wirkungen des Makrophagen-migrationsinhibierenden Faktors (MIF) auf das Tumorsuppressorprotein p53 bei der ROS-induzierten Apoptose
… (PI3K-Akt-Pathway) effects of the cytokine MIF (Macrophage Migration Inhibitory factor) have been examined and brought in connection with antiapoptotic and pro-proliferative effects. The functions as redox-active cytokine (redox acting cytokine = "Redoxkine"), which have been linked to …
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Expression of Macrophage Migration Inhibitory Factor in Behçet's disease
PURPOSE: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation, immune response, and cell growth. Previous reports showed that MIF-173 G>C polymorphism or the MIF-794 [CATT]5-8 polymorphism and haplotypes containing these variants were associated with an …
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Role for Macrophage Migration Inhibitory Factor in Multiple Sclerosis
… di inibizione della migrazione dei macrofagi (MIF) è una citochina proinfiammatoria che svolge un ruolo importante nella patogenesi di numerosi disordini infiammatori e autoimmuni. Come tale, è un obiettivo terapeutico interessante per il trattamento di questi disturbi. Diversi dati …
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Design and analysis of transmission strategies in wireless relay networks
… to as mutual information based forwarding (MIF) for memoryless relay networks is proposed. An analytical framework to evaluate the error performance of the proposed MIF scheme in both additive white Gaussian noise and Rayleigh fading channels is presented. Furthermore, it is shown that MIF …
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Identification of novel chemokine and chemokine-like mechanisms in leukocyte adhesion and atherosclerotic lesion formation
… the pleiotropic functions of the CLF chemokine MIF. MIF plays a critical role in inflammatory diseases and atherogenesis and attracts immune cells to sites of inflammation. The only known cell surface receptor for MIF is CD74, which can mediate sustained activation of ERK/MAPK. Yet, no receptor …
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Untersuchungen zur Blockade des Makrophagen-Migrations-Inhibitionsfaktors in der Experimentellen Autoimmunen Enzephalomyelitis
Der Makrophagen-Migrations-Inhibitionsfaktor (MIF) ist ein Chemokin, das eine wichtige Rolle bei der Regulation der Effektorfunktionen von Makrophagen und bei der T-Zell-Aktivierung und -Migration innehat. Untersuchungen zur Bedeutung des Chemokins in der Pathogenese von Autoimmunkrankheiten, wie …
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A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses
… macrophage migration inhibitory factor (MIF). These two MIF-like sequences show 22% sequence identity when aligned with human MIF, and are most likely the result of gene duplication. The Lm1740MIF and Lm1750MIF genes (58% identity) are expressed in all developmental stages of L. major. …
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Exploring the contributions of liquid-phase sulfur chemistry to the mass-independent sulfur fractionation of the Archean rock record
Archean sulfur mass-independent fractionation (S-MIF) has been widely recognized as one of the strongest indicators for the rise of atmospheric oxygen in the Early Proterozoic. A decade after its discovery, the wide-ranging implications of Archean sulfur MIF have been discussed extensively and …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… of the macrophage migration inhibitory factor (MIF). MIF is a 12.5 kDa chemokine-like inflammatory mediator, whose ligand is the transmembrane receptor CD74. Recent data suggests that CD74 is involved in proinflammatory responses and tumorigenesis but detailed mechanisms are not fully …
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Regulation of CD74 expression in response to Human Interferon Gamma and Lipopolysaccharide on Human Trophoblast Derived Cells: Relevance for Human Feto-Maternal Tolerance.
… and a macrophage migration inhibitory factor (MIF) receptor. CD44 is the signalling component of the MIF-CD74 receptor complex. The expression of CD74, MIF and CD44 was studied in the human trophoblast-derived cell lines JEG-3 and ACH-3P by RT-PCR, flow cytometry, Western blot, …
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Expressão do fator inibitório da migração de macrófagos e do fator de permeabilidade vascular em lesões da cérvice uterina induzidas pelo papilomavírus humano
… cancer. Macrophage migration inhibitory factor (MIF) is produced by different cell types and participates in a complex chain of events that favors the process of carcinogenesis, being possible to observe a high expression level in almost all types of human cancer, such as in cervical cancer. MIF …
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Μελέτη του ρυθμιστικού ρόλου του παράγοντα αναστολής της μετανάστευσης των μακροφάγων (MIF) στην επίδραση των κορτικοειδών στην παραγωγή μεταλλοπρωτεασών και των ενδογενών αναστολέων τους, κυτταροκινών και κολλαγόνου στο ρινικό πολύποδα
… αναστολής της μετανάστευσης των μακροφάγων (MIF) στον ιστό από ρινικό πολύποδα αλλά και στον φυσιολογικό ρινικό βλεννογόνο, καθώς και η ικανότητα αυτού να εξουδετερώνει την ανασταλτική δράση των γλυκοκορτικοειδών (ΓΚ) στην επαγόμενη από διάφορους αυξητικούς παράγοντες παραγωγή διαμεσολαβητών, …
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