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Showing 1 to 13 of 13 for “"MICAL"”.
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Characterizing New Molecules and Mechanisms of Semaphorin/Plexin/MICAL Signaling
… characterizing a new family of proteins, the MICALs that were identified as cytoplasmic binding partners of the Semaphorin receptor Plexin. Combining Drosophila genetics with in vitro biochemical assays, my work revealed that Mical regulates actin organization both in vivo and in vitro and is …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… a family of unusual proteins called the MICALs (which includes one Drosophila Mical and three vertebrate MICALs), which associate with the Semaphorin cell-surface receptor Plexin and are important for Semaphorins to exert their effects. Nothing was known, however, regarding the specific …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… a family of unusual proteins called the MICALs (which includes one Drosophila Mical and three vertebrate MICALs), which associate with the Semaphorin cell-surface receptor Plexin and are important for Semaphorins to exert their effects. Nothing was known, however, regarding the specific …
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Regulation of Mical Redox Post-Translationally-Driven F-Actin Cytoskeletal Dynamics
… we identified a new actin regulatory protein Mical, which directly associates with both the Semaphorin receptor Plexin and F-actin to post-translationally oxidize actin on its conserved methionine-44 and methionine-47 residues, inducing both F-actin disassembly and altered actin …
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STRUCTURE-FUNCTION STUDIES OF NOVEL MEDICALLY RELEVANT FLAVOENZYMES
… and pathologies. The production and biochemical characterization of two medically-relevant flavoenzymes will be discussed. In a last section we will address a combined computational and experimental study on flavocytochrome b2, a well-characterised flavoenzyme, whose catalytic mechanism is …
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Predictive model to estimate ionized calcium from routine serum biochemical profiles in dogs
… ionized calcium concentration from serum biochemical values and (2) compare the diagnostic performance of predicted ionized calcium (piCa) to those of total calcium (tCa) and two corrected tCa formulae; and (3) study the relationship between biochemical values and variation of measured ionized …
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Race and Anomie: A Comparison of Crime Among Rural Whites and Urban Blacks Based on Social Structural Conditions.
<p>This study examined the relationship between social structures and crime among rural white and urban black males in North Carolina through the theoretical framework of Merton's Anomie. Using demographic information on the state's inmate population provided by the North Carolina Department of …
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Reproduction and establishment of two endangered African cedars, Widdringtonia cedarbergensis and Widdringtonia whytei
In this thesis I determine the effect of population decline on reproduction for two critically endangered African cedars. Widdringtonia whytei (Mulanje cedar) endemic to Mt Mulanje, in Malawi and Widdringtonia cedarbergensis (Clanwilliam cedar) endemic to the Cedarberg Mountains in the Western Cape …
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Certain syndrome or complex conundrum? : the pollination of Erica lanuginosa
The flower of Erica lanuginosa has a tightly closed corolla, held in place by hinged sepals. with a dull reddish-pink colour which makes make it hard to determine a likely pollinator. Rodent trapping and pollen analysis of faecal matter showed it unlikely to be pollinated by a rodent. Flowers …
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Shade or light? : size class distribution and δ¹³C values as clues to the recruiting environment of Widdringtonia whytei
In order to determine the recruitment environment of the endangered Mulanje Cedar, Widdringtonia whytei, size class distributions were measured for six populations on Mount Mulanje, Malawi. Carbon isotope ratios were also collected from leaf tissue in trees of varying height in order to determine …
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Functional assessment of amputee performance
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1992.
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Redox manipulation alters hippocampal neuron response to semaphorin 3A
… reactions such as the oxidizing function of Mical proteins on f-actin that function downstream of Sema3A. However, what is less understood is how various redox conditions alter these guiding cues. This work investigates the subcellular redox state of hippocampal neurons and the effects redox …