Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MIAPaCa-2"”.
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Development of monoclonal antibodies for the identification of novel invasion associated targets in human cancer.
… of MAbs directed against the highly invasive MiaPaCa-2 clone 3 pancreatic cell line, and the MDA-MB-435-SF breast cancer cell line. Two MAbs were identified that could successfully block cancer invasion in vitro. MAb 7B7 G5 (2) significantly reduced invasion in the MiaPaCa-2 clone 3 pancreatic …
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Impact du niveau d'activation de la voie Notch/HES1 dans le maintien du phénotype transformé des cellules pancréatiques cancéreuses
… issues d’adénocarcinomes pancréatiques humains : MIAPaCa-2 et BxPC-3 ; celles-ci ont été traitées avec des inhibiteurs de gamma-sécrétase et infectées par des lentivirus codant pour des shARNs ciblant de manière spécifique les ARNm de Notch1 ou Hes1. Nos RÉSULTATS démontrent que les cellules …
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Nanomaterials and Block Copolymers for Overcoming Multidrug Resistance in Cancer
… pancreatic adenocarcinoma cell lines MiaPaCa-2 and PANC-1, an in vitro analysis of the synergistic effect using 5-fluorouracil in conjugation with Pluronic® F127 was performed. By monitoring cell viability and regulation of cell cycle, we were able to show that compared to the use of …
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Molecular mechanisms of drug resistance, invasion and metastasis in pancreatic carcinoma
… model was established by single cell cloning of MiaPaCa-2, yielding sub-clones displaying diverse invasive properties. The malignant phenotypes of MiaPaCa-2, Clone #3 (highly invasive) and Clone #8 (poorly invasive) were characterised, comparative proteomic profiling by 2-D DIGE, MALDI-TOF MS and …
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Role of Methyltransferase Like-3 (Mettl3) In Pancreatic Ductal Adenocarcinoma (Pdac) Progression
… human pancreatic cancer cell lines (Panc-1 and MiaPaca-2) using shRNA targeting and performed in vitro assays to determine differences in growth and migratory characteristics upon METTL3 knockdown. METTL3 loss decreased proliferation and migration rates in MiaPaca-2 cells and decreased …
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Role and Regulation of Epha2 In Pancreatic Cancer
… 2 orthotopic models in vivo: 1) shRNA-pretreated Miapaca-2 cells, and 2) in vivo delivery of siRNA to established MPanc96 tumors. Silencing of EphA2 alone reduced tumor growth in Miapaca-2 cells. In MPanc96, only the combination treatment of gemcitabine plus siEphA2 significantly reduced tumor …
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Structure Based Drug Design of High Affinity Kras Inhibitors
… selectivity towards inhibiting proliferation of MiaPaCa-2 cells. We then screened a second small-molecule library based on M1 and generated additional hits which decreased mutant KRAS signaling. Likewise, we generated two derivatives of compound 11 which were tested and gave insights to critical …