Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MHCI"”.
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Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
… major histocompatibility complex class I: MHCI) antigen presentation can help viruses to evade cytotoxic T-lymphocyte: CTL) detection and clearance. Cowpox virus, like other orthopoxvirus family members, is a large DNA virus, whose genomic termini encode numerous immunomodulatory genes, …
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Understanding antigen processing in chickens using genome editing technology
… associated with antigen processing (TAP) for MHCI molecules, and the dedicated chaperone DM for the MHCII molecules. In mammals, these critical antigen loading molecules have limited polymorphism, providing peptides for a multigene family of well-expressed classical MHC molecules. Outside of …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
… The adoptive transfer of OVA specific MHCI restricted (OT-I) and MHCII restricted (OT-II) TCR Tg T cells extended the OVA Tg mouse model by allowing potentially encephalitogenic T cells to be tracked in vivo. Specificity for the target Ag should enable the dynamic role of antigen …
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The effect of insulin treatment and exercise modality on skeletal muscle fiber size in streptozotocin-induced type 1 diabetic rats
… (all fibers expressing fast MHC’s except MHCIIx/IIb and MHCiib – P0.05). Surprisingly, DIT exhibited significantly larger MHCIIa and fewer hybrid fibers than any other group. MHCI fibers were unaffected by either diabetes or exercise, however, exercised animals displayed changes in percent …
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
… DC-like features such as expression of CD11c, MHCII and co-stimulatory molecules, yet their role in T cell activation is still a matter of investigation. Cells similar to DCs can also be produced in vitro by culturing monocytes with granulocyte-macrophage colony-stimulating factor (GM-CSF) or …
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Effects of mannan oligosaccharide on immune function and disease resistance in pigs
… a cytotoxic T cell immune response by enhancing MHCI mRNA expression, but reduce the expression of complement system-associated molecules and 2’,5’-oligoadenylate synthetase-1. The downregulation of inflammatory responses regulated by MOS at d 7 PI was associated with several important canonical …
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Studying the Patterning Mechanisms and Cell Fates during Limb Regeneration in Ambystoma mexicanum
We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight …