Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"MHC-molecule"”.
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The Role of Qa-2, the Functional Homolog of HLA-G, in a Mouse Model of Behcet's Disease Induced by HSV Inoculation
… leukocyte antigen-G) is a nonclassical class I MHC molecule. HLA-G interacts with different natural killer (NK) cell receptors and is able to inhibit NK and T-cell cytotoxicity, as well as T-cell proliferation. An HLA-G 3741_3754 14-base pair insertion allele was significantly more frequent in …
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Structural basis for escaping negative selection by T cell receptor with high affinity for self antigen
… relatively unstable complexes with self-peptide-MHC. These TCRs adopt suboptimal docking topologies in striking contrast to the classical topology of anti-microbial TCRs. Alternatively, escape can occur by weak binding between self-peptides and MHC. We determined the structure of a human …
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The dependence of CD4 T cell development and activation on the kinetics of the TCR:pMHC interaction
… to bind a peptide antigen presented on an MHC molecule by an antigen presenting cell: APC). The strength of this interaction is determined by the ratio of the rate of dissociation: k<sub>off</sub>) and the rate of association: k<sub>on</sub>) between the TCR and the pMHC. The overall …
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Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands
… aglycosylated extracellular portion of the molecules, making it impossible to assess the importance of the receptor anchor and glycosylation on ligand binding. We used a micropipette adhesion frequency assay to demonstrate that the anchor length affects the forward rate and affinity of CD16s …
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Support Vector Machine-based Fuzzy Systems for Quantitative Prediction of Peptide Binding Affinity
… and a major histocompatibility complex (MHC) molecule(s). Recent research efforts have been focused on quantifying the binding predictions. The objective of this thesis is to develop reliable real-value predictive models through the use of fuzzy systems. A non-linear system is proposed …
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In silico prediction of C57BL/6 mouse T-cell epitopes: enhancing immunogenicity assessment with PREDBL6
The MHC class I antigen processing pathway involves multiple steps: 1) the proteasome selectively cleaves intracellular proteins into short peptides, typically 8–11 amino acids long; 2) TAPs (transporter associated with antigen processing) selectively transport some of these peptides to the …
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Modulation of the T cell response with MHC class I peptides and their analogues
… outcome. T cell recognition of foreign MHC molecules plays a key role in initiating and sustaining allograft rejection. To prevent the risk of rejection, patients are given immunosuppressive drugs, which are non-specific and have major side-effects (infections, malignancies). It has been …
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Immune gene expression and diversity in relation to gastrointestinal parasite burden in small mammals
MHC genes encode proteins that are responsible for the recognition of foreign antigens and the triggering of a subsequent, adequate immune response of the organism. Thus they hold a key position in the immune system of vertebrates. It is believed that the extraordinary genetic diversity of MHC …
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Host-parasite co-evolution and genetic variation at the major histocompatibility complex in the Trinidadian guppy (poecilia reticulata)
The Major Histocompatibility Complex (MHC) is a region of the vertebrate genome believed to be responsible for an individual's ability to detect and recognise invading parasites. The MHC molecule has been shown to bind to short fragments of parasite and present these to the adaptive immune system. …
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How CD4+ T Cells Recognize Allostimulatory Peptide-MHC
… (non-self) Major Histocompatibility Complex (MHC) molecules in addition to their conventional ligands, peptides presented on self MHC. It is an enigma as to how these alloreactive T cells can bind to allogeneic MHC given that T cells undergo stringent positive selection during development to …
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Über den Beitrag von Valpha- und Jalpha-Segmenten des T-Zellrezeptors von CD8 T-Zellen der Ratte bei RT1f-spezifischer Alloreaktion und positiver Selektion im Thymus
Va8.2+ CD8 T-Zellen von LEW.1F Ratten (MHC-Haplotyp f) werden während der Reifung im Thymus zehnfach überselektioniert: 14 Prozent der reifen LEW.1F CD8 T-Zellen exprimieren Va8.2; CD8 T-Zellen von MHC kongenen RT1f- Stämme sind nur zu 1-2 Prozent Va8.2+. Gleichzeitig führt die RT1f-spezifische …
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The Major Histocompatibility Complex in Rabbits
… place. The major histocompatibility complex (MHC) is a key component of the immune system’s response to both fight disease and maintain health. Present in all jawed vertebrates, the MHC has played a key role in immunocompetence for over 400 million years. Its primary function in adaptive …