Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 56 for “"MHC-II"”.
-
Die Rolle der DNA-Methylierung in der Kontrolle des MHC-II-spezifischen Typ-IV-Promotors in Thymomen
… Moleküle des „major histocompatibility complex“ (MHC) spielen in der thymischen T-Zell-Reifung eine zentrale Rolle. Durch Interaktion des T-Zell-Rezeptors auf der unreifen T-Zelle und den Co-Rezeptoren CD4 und CD8 mit dem MHC auf dem Thymusepithel werden die zwei wichtigsten Reifungs- und …
-
Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… in-depth understanding of T-cell responses to MHC class I (MHC-I) and MHC class II (MHC-II) tumor antigens that are derived from aberrant expression of non-mutant antigens or driver and passenger somatic alterations that can function as tumor neoantigens. We used a poorly immunogenic …
-
Kinetics and Intracellular Pathways Required for MHC Ii-Peptide Loading and Surface Expression of a Hapten-Protein Conjugate in Murine Macrophage
… of the major histocompatibility complex class II molecule (MHC II). The sequence of events that lead to the formation of these MHC II-peptide complexes has been termed antigen processing, and several specific questions related to this pathway remain unanswered. Therefore, a novel fluorescent …
-
The Major Histocompatibility Complex in Rabbits
… place. The major histocompatibility complex (MHC) is a key component of the immune system’s response to both fight disease and maintain health. Present in all jawed vertebrates, the MHC has played a key role in immunocompetence for over 400 million years. Its primary function in adaptive …
-
Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… while decreasing the frequency of CD11a and MHC II on the splenic CD11c<sup>high</sup> DCs. Although TCDD did not alter the number and frequency of CD11c<sup>low</sup> splenic DCs, it decreased their MHC II and CD11a expression. The loss of CD11c<sup>high</sup> DC was independent of an …
-
Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… while decreasing the frequency of CD11a and MHC II on the splenic CD11c<sup>high</sup> DCs. Although TCDD did not alter the number and frequency of CD11c<sup>low</sup> splenic DCs, it decreased their MHC II and CD11a expression. The loss of CD11c<sup>high</sup> DC was independent of an …
-
Induction of Stronger and Long Lasting Vaccine Immunity to Tuberculosis
… of CD4 and CD8 T cells respectively through MHC-II and MHC-I pathways. Furthermore, BCG reduces the expression of MHC-II in macrophages of mice after infection, through Toll-like receptor-1/2 (TLR-1/2) mediated signaling. In my first aim, I hypothesized that BCG-induced reduction of MHC-II …
-
Regulation of Adaptive Immunity in the Lung by the Alveolar Epithelial Type II Cell and Surfactant Protein a
… or asthma. The alveolar epithelial type II cell and its secretory product, surfactant protein A (SP-A), have been linked to roles in adaptive immunity in the lung. The discovery that type II cells constitutively express major histocompatibility complex class II (MHC II) suggested that …
-
Immunogenetics of free-ranging felids on Namibian farmlands
… diseases. The Major Histocompatibility Complex (MHC) is a gene family that plays a central role in the vertebrate’s immune system by triggering the adaptive immune response after exposure to pathogens. MHC genes have become highly suitable molecular markers of adaptive significance. They …
-
Type B Presentation from HEL Protein in the Context of Inflammation
… egg white lysozyme: HEL) are capable of binding MHC II in multiple conformations. Resting antigen presenting cells: APC) load peptide in early endosomal compartments where multiple conformations of a given pMHC pair are allowed, generating both type A and B pMHC complexes. Protein traffics to the …
-
Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
TAPBPR is a chaperone within the MHC-I antigen processing and presentation pathway, responsible for shaping the immunopeptidome via MHC-I peptide editing and the recycling of sub-optimally loaded MHC-I to the peptide loading complex. As such, TAPBPR plays an essential role in the activation of the …
-
Identification of Markers to Predict Benefit from Trastuzumab Treatment
… Accordingly TRAR-low, high-NKG2D- and -MHC-II-expressing tumours were associated with response to one cycle of trastuzumab alone. In addition, increase of MHC-II gene expression upon a single cycle of trastuzumab characterised patients who benefit from the following combination with …
-
Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain
… cells (APC) by expressing class II major histocompatibility complex (MHC) antigens and co-stimulatory molecules upon activation. In vitro, astrocytes are activated by lipopolysaccharides (LPS), and interferon-gamma (IFN-gamma). We previously reported that gangliosides, membrane …
-
Estrogene verzögern die Entwicklung der Transplantatvaskulopathie nach Herztransplantation - Experimentelle Untersuchungen im Kleintiermodell
… von T-Helferzellen, T-Suppressorzellen, MHC-II-Strukturen, Makrophagen und ICAM-1 wurde außerdem gezeigt, dass die myointimale MHC-II-Expression durch 17-ß-Estradiol bzw. Coumestrol-Gabe signifikant geringer ausgeprägt war. Ebenso die Infiltratdichte an Makrophagen und CD8-positiven …
-
Astrocytes modulate microglial phenotype and dendritic cell-like properties
… healthy CNS, they express negligible levels of MHC II molecules as well as co-stimulatory molecules CD40, CD80 and CD86 necessary for antigen presentation to and activation of T cells. Co-stimulatory molecule expression can be induced in isolated microglia in vitro by sequential treatment with …
-
Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
… of major histocompatibility complex class I (MHC-I) and II (MHC-II) on the surface of AECs. Furthermore, as seen through histone modifications, I confirmed that RSV infection causes lasting epigenetic changes in AECs, including in the promoters of genes related to MHC biology. Our results lay …
-
Investigating the role of kidney mononuclear phagocytes in immune complex-induced inflammation.
… based on their expression of F4/80, CD11b and MHC II. These subsets differed in their localization within the organ, IgG Fc receptor expression, and their ability to survey the circulation and present MHC II-peptide complexes, the latter varying with IgG opsonization and IgG IC size. In …
-
Interleukin-6 trans-signaling: implications for neuroinflammation and cognitive deficits in the aged
… that the IL-6 trans-signaling pathway stimulated MHC-II, a marker of activation. While microglia isolated from aged IL-6 knock-out animals displayed significantly less MHC-II expression. Additionally, IL-6 knock-out animals were refractory to LPS-induced sickness behavior implicating the …
-
Investigating transmembrane TNF and transmembrane p55TNFR mediated signaling in host immune function during Mycobacterium tuberculosis infection
… reflected by enhanced cell surface expression of MHC-II, CD80 and CD86 as well as enlargement of granulomas. Furthermore, our results show that solTNF has a regulatory function that modulates the magnitude of Th1 immune responses during acute and chronic stages of the infection. The evaluation of …
-
Identifizierung und molekulare Charakterisierung des lysosomalen Matrixproteins Serincarboxypeptidase 1
… von Hormonen und der Antigenpräsentation via MHC II beteiligt. Bis heute sind mehr als 40 lysosomale Speichererkrankungen, die auf einen Defekt lysosomaler Hydrolasen zurückzuführen sind, sowie zahlreiche Lysosomen-assoziierte Erkrankungen mit unbekannter Ätiologie beschrieben.Zur …
Page 1 of 3