Global ETD Search
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Showing 1 to 20 of 62 for “"MHC-II"”.
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T-Zell-unabhängige MHC-II-Signaltransduktion durch Superantigene
For a couple of years MHC-II complexes are known for many more assignments than antigen presentation. In this thesis the quite unknown mechanism of superantigen-induced T cell independent MHC-II-signaltransduction is investigated. It could be demonstrated that the superantigen-induced …
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Die Rolle der DNA-Methylierung in der Kontrolle des MHC-II-spezifischen Typ-IV-Promotors in Thymomen
… Moleküle des „major histocompatibility complex“ (MHC) spielen in der thymischen T-Zell-Reifung eine zentrale Rolle. Durch Interaktion des T-Zell-Rezeptors auf der unreifen T-Zelle und den Co-Rezeptoren CD4 und CD8 mit dem MHC auf dem Thymusepithel werden die zwei wichtigsten Reifungs- und …
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Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… in-depth understanding of T-cell responses to MHC class I (MHC-I) and MHC class II (MHC-II) tumor antigens that are derived from aberrant expression of non-mutant antigens or driver and passenger somatic alterations that can function as tumor neoantigens. We used a poorly immunogenic …
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Kinetics and Intracellular Pathways Required for MHC Ii-Peptide Loading and Surface Expression of a Hapten-Protein Conjugate in Murine Macrophage
… of the major histocompatibility complex class II molecule (MHC II). The sequence of events that lead to the formation of these MHC II-peptide complexes has been termed antigen processing, and several specific questions related to this pathway remain unanswered. Therefore, a novel fluorescent …
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The characterization of major histocompatibility complex class II signal transduction pathways in antigen presenting cells
Major histocompatibility complex class II (MHC-II) molecules, which can be broken down into three different human isotypes, HLA-DR, HLA-DP, and HLA-DQ, are expressed on a wide range of immune cells including B lymphocytes, monocytes/macrophages and dendritic cells. Although MHC-II molecules are …
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The Major Histocompatibility Complex in Rabbits
… place. The major histocompatibility complex (MHC) is a key component of the immune system’s response to both fight disease and maintain health. Present in all jawed vertebrates, the MHC has played a key role in immunocompetence for over 400 million years. Its primary function in adaptive …
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Untersuchung von antigenpräsentierenden Funktionen bei kultivierten hepatischen Sternzellen und transdifferenzierenden Myofibroblasten der Ratte
… as (RT1B, RT1D) (alpha- and beta-chain) of the MHC II complex, and the co-stimulatory molecules CD80 and CD86. The expression, however, decreases during the course of transdifferentiation. After stimulation with the proinflammatory cytokine IFN-gamma, the expression of the MHC II genes RT1B and …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… while decreasing the frequency of CD11a and MHC II on the splenic CD11c<sup>high</sup> DCs. Although TCDD did not alter the number and frequency of CD11c<sup>low</sup> splenic DCs, it decreased their MHC II and CD11a expression. The loss of CD11c<sup>high</sup> DC was independent of an …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… while decreasing the frequency of CD11a and MHC II on the splenic CD11c<sup>high</sup> DCs. Although TCDD did not alter the number and frequency of CD11c<sup>low</sup> splenic DCs, it decreased their MHC II and CD11a expression. The loss of CD11c<sup>high</sup> DC was independent of an …
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Induction of Stronger and Long Lasting Vaccine Immunity to Tuberculosis
… of CD4 and CD8 T cells respectively through MHC-II and MHC-I pathways. Furthermore, BCG reduces the expression of MHC-II in macrophages of mice after infection, through Toll-like receptor-1/2 (TLR-1/2) mediated signaling. In my first aim, I hypothesized that BCG-induced reduction of MHC-II …
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Regulation of Adaptive Immunity in the Lung by the Alveolar Epithelial Type II Cell and Surfactant Protein a
… or asthma. The alveolar epithelial type II cell and its secretory product, surfactant protein A (SP-A), have been linked to roles in adaptive immunity in the lung. The discovery that type II cells constitutively express major histocompatibility complex class II (MHC II) suggested that …
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Immunogenetics of free-ranging felids on Namibian farmlands
… diseases. The Major Histocompatibility Complex (MHC) is a gene family that plays a central role in the vertebrate’s immune system by triggering the adaptive immune response after exposure to pathogens. MHC genes have become highly suitable molecular markers of adaptive significance. They …
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Type B Presentation from HEL Protein in the Context of Inflammation
… egg white lysozyme: HEL) are capable of binding MHC II in multiple conformations. Resting antigen presenting cells: APC) load peptide in early endosomal compartments where multiple conformations of a given pMHC pair are allowed, generating both type A and B pMHC complexes. Protein traffics to the …
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Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
TAPBPR is a chaperone within the MHC-I antigen processing and presentation pathway, responsible for shaping the immunopeptidome via MHC-I peptide editing and the recycling of sub-optimally loaded MHC-I to the peptide loading complex. As such, TAPBPR plays an essential role in the activation of the …
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Identification of Markers to Predict Benefit from Trastuzumab Treatment
… Accordingly TRAR-low, high-NKG2D- and -MHC-II-expressing tumours were associated with response to one cycle of trastuzumab alone. In addition, increase of MHC-II gene expression upon a single cycle of trastuzumab characterised patients who benefit from the following combination with …
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Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain
… cells (APC) by expressing class II major histocompatibility complex (MHC) antigens and co-stimulatory molecules upon activation. In vitro, astrocytes are activated by lipopolysaccharides (LPS), and interferon-gamma (IFN-gamma). We previously reported that gangliosides, membrane …
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Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
… of major histocompatibility complex class I (MHC-I) and II (MHC-II) on the surface of AECs. Furthermore, as seen through histone modifications, I confirmed that RSV infection causes lasting epigenetic changes in AECs, including in the promoters of genes related to MHC biology. Our results lay …
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Estrogene verzögern die Entwicklung der Transplantatvaskulopathie nach Herztransplantation - Experimentelle Untersuchungen im Kleintiermodell
… von T-Helferzellen, T-Suppressorzellen, MHC-II-Strukturen, Makrophagen und ICAM-1 wurde außerdem gezeigt, dass die myointimale MHC-II-Expression durch 17-ß-Estradiol bzw. Coumestrol-Gabe signifikant geringer ausgeprägt war. Ebenso die Infiltratdichte an Makrophagen und CD8-positiven …
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Astrocytes modulate microglial phenotype and dendritic cell-like properties
… healthy CNS, they express negligible levels of MHC II molecules as well as co-stimulatory molecules CD40, CD80 and CD86 necessary for antigen presentation to and activation of T cells. Co-stimulatory molecule expression can be induced in isolated microglia in vitro by sequential treatment with …
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Investigating the role of kidney mononuclear phagocytes in immune complex-induced inflammation.
… based on their expression of F4/80, CD11b and MHC II. These subsets differed in their localization within the organ, IgG Fc receptor expression, and their ability to survey the circulation and present MHC II-peptide complexes, the latter varying with IgG opsonization and IgG IC size. In …
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