Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"MHC-I"”.
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The Oncogenic Map Kinase Signaling Pathway Modulates Mhc-I Surface Expression In Melanoma
… of major histocompatibility complex I molecules (MHC-I) on the cell surface, and potentially allow melanoma cells to escape immune system surveillance. MHC-I molecules expressed by tumor cells are the crucial targets recognized by CTLs to kill tumor cells; thus, strategies to improve MHC-I antigen …
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Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… in-depth understanding of T-cell responses to MHC class I (MHC-I) and MHC class II (MHC-II) tumor antigens that are derived from aberrant expression of non-mutant antigens or driver and passenger somatic alterations that can function as tumor neoantigens. We used a poorly immunogenic …
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The Cytoplasmic Tail of Mhc Class I Molecules Plays A Critical Role In Dendritic Cell-Induced T Cell Immunity
<p>The presentation of MHC class I (MHC-I)/peptide complexes by dendritic cells (DCs) is critical for the maintenance of central tolerance to self and for the regulation of cytotoxic T lymphocytes (CTL)-mediated adaptive immune responses against pathogens and cancer cells. Interestingly, several …
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
Major Histocompatibility Complex (MHC) Class I molecules present peptides to CD8⁺ T cells and are essential for most adaptive immune responses. The first described-spliced tapasin (“isoform 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules …
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Single muscle fiber contractile properties with run training
… myofibers were isolated and studied at 15°C. MHC I diameter was 3% lower (P < 0.05) at T2 compared to T1 and 4% smaller at T3 compared to T2. MHC I and Ila fibers were 18 and 11 % stronger (P < 0.05) respectively, from T1 to T2. MHC I fibers produced 9% less force (P < 0.05) after the taper …
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Multiomic Investigation of the Human Gut Toward Insight into Childhood Inflammatory Bowel Disease Pathogenesis
… in the major histocompatibility complex class I (MHC I) signaling pathway are particularly interesting. The MHC I pathway represents a promising candidate mechanism of IBD as it is involved in the communication between cells and the immune system. Finally, I follow up on the association of MHC I …
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Utilising recombinant TAPBPR technology to investigate MHC class I peptide editing and therapeutic applications
Major histocompatibility complex class I (MHC-I) molecules play a crucial role in the immune response to infection and malignancy by presenting peptides to CD8+ T cells. Optimal peptide:MHC-I complexes are generated in the MHC-I antigen processing and presentation pathway. In this pathway, TAPBPR …
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Characterisation of TAPBPR in immune cells
… called the major histocompatibility complex (MHC). MHC class I (MHC-I) molecules are polymorphic structures that can display a large repertoire of peptides. Peptide loading occurs in the context of a multi-protein machinery called the peptide loading complex (PLC). A key player in the initial …
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Molecular Signatures of Adaptation: MHC Evolution and Natural Selection in European Rabbits
The Major Histocompatibility Complex (MHC) is a multi-gene family, covering a genomically complex region that plays a pivotal role in immune surveillance and pathogen recognition. Within this region, only a subset of MHC class I (MHC-I) genes encodes classical molecules that present peptides to …
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Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
TAPBPR is a chaperone within the MHC-I antigen processing and presentation pathway, responsible for shaping the immunopeptidome via MHC-I peptide editing and the recycling of sub-optimally loaded MHC-I to the peptide loading complex. As such, TAPBPR plays an essential role in the activation of the …
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Elucidation of Mechanisms of Host Immunity against Orientia tsutsugamushi in a Newly Developed Murine Model
… bacterial loads. We further studied CD8-/-, MHC I-/- and wild type control (WT) C57BL/6J mice to determine the importance of CD8+ T cells and MHC I molecules. After infection with an ordinarily sub-lethal dose of O. tsutsugamushi, all CD8-/- and MHC I-/- mice expired between 12 and 15 dpi, …
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MHC Class I Tyrosine Phosphorylation Site Y320 Augments CD8+ T Cell Priming, Effector Function, and Memory Response
<p>The cytoplasmic domain of MHC class I (MHC-I) molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a Y320F-mutated form of H-2K<sup>b</sup> had reduced capacity to generate K<sup>b</sup>-restricted cytotoxic T lymphocyte (CTL) …
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Rerouting Pre-Existing Host Vaccine-Induced Immunity to wards Breast Cancer
… and present the antigens in complex with MHC on the cell surface. We chose HER2-breast cancer as a model for proof-of-principle.</p> <p>In our study, we first examined MHC-I expression, which is required for mediating T cell-mediated response, in a panel of breast cancer cell lines with …
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Immunogenetics of free-ranging felids on Namibian farmlands
… diseases. The Major Histocompatibility Complex (MHC) is a gene family that plays a central role in the vertebrate’s immune system by triggering the adaptive immune response after exposure to pathogens. MHC genes have become highly suitable molecular markers of adaptive significance. They …
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Functional Characterization of the HIV-1 NEF Acidic Cluster
… of major histocompatibility complex I (MHC-I), (2) the downregulation of CD4, (3) infectivity enhancement, and (4) Pak2 activation. These in vitro effects, with the exception of CD4 downregulation, rely in part upon Nef's acidic cluster which has been reported to affect Nef's redirection …
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The immunogenicity of embryonic stem cell-derived midbrain dopaminergic progenitors and its implications as a therapy to treat patients with Parkinson’s Disease
… latter would be the environment post-transplant. MHC-I expression was low in mDAps but was upregulated in inflammatory conditions; MHC-II and the co-stimulatory molecules always remained undetectable. To assess their immunogenicity in vitro, they were co-cultured with peripheral blood mononuclear …
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The Major Histocompatibility Complex in Rabbits
… place. The major histocompatibility complex (MHC) is a key component of the immune system’s response to both fight disease and maintain health. Present in all jawed vertebrates, the MHC has played a key role in immunocompetence for over 400 million years. Its primary function in adaptive …
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Klonierung und Charakterisierung eines polymorphen MHC Kl. I-Moleküls der LEW.1F-Ratte, das präferentiell Va8.2-exprimierende CD8-T-Zellen expandiert
Der MHC der Lewis.1F-Ratte (RT1f) stimuliert die präferentielle Expansion von CD8-T-Zellen, die das V-Segment 8.2 (AV8S2) der TCR-alpha-Kette verwenden. Sowohl als Folge der positiven thymischen Selektion in der Lewis.1F-Ratte (LEW.1F) wie auch bei der RT1f-Alloerkennung. Es war Ziel dieser Arbeit, …
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