Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"MHC class II"”.
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VIRAL MODULATION OF MHC CLASS II-MEDIATED ANTIGEN PRESENTATION
… of antigen presentation cells (APC) perturbs MHC class II-mediated antigen (Ag) presentation. The goals of this project include: 1) to define mechanisms by which VV disrupts class II presentation; and 2) to examine whether disruption of the class II pathway by VV alters T cell responses in …
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Defining Mechanisms Contributing to Porcine MHC Class II Diversity
… (DQB: P=0.011 and DRB1: P=0.015) at both MHC loci, between the domestic and Wild boar populations. The European and Asian domestic populations exhibited a higher level of DQB amino acid diversity (0.093 and 0.093, respectively) when compared to the respective Wild boar populations (0.047 …
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Intracellular processing events leading to MHC class II-mediated presentation of a cytoplasmic antigen
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Autophagy Delivers Viral Antigens for MHC Class II Presentation and is Regulated by Viral Infection
<p>MHC class II molecules generally present peptides derived from exogenous antigens after endocytosis. However, biochemical studies have revealed that MHC class II ligands are frequently derived from intracellular proteins after endogenous processing. Endogenous MHC class II antigen presentation …
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Polymorphism of bovine MHC class II genes: Association with persistent lymphocytosis caused by bovine leukemia virus
… of bovine major histocompatibility complex (MHC) class II DQA, DQB, and DRB genes was investigated by sequence comparisons between class II genes of cattle and other species. The association between BoLA-DRB3 alleles and persistent lymphocytosis (PL) caused by bovine leukemia virus infection …
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B Cell Signaling and Bioinformatics: Revealing Components of the MHC Class II Antigen Processing and Presentation Pathway
… the development of a bioinformatics tool termed CLASSIFI (Cluster Assignment for Biological Inference), which identifies statistically significant co-clustering of genes with similar Gene Ontology annotation within microarray gene clusters. CLASSIFI was used to analyze microarray results from two …
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The characterization of MHC Class II genes of the Nile crocodile (Crocodylus niloticus) : an investigation of mechanisms that shape genetic diversity in natural populations
… within the Major Histocompatibility Complex (MHC) of vertebrates code for proteins that are involved in antigen recognition and activation of the adaptive immune response. The hallmark of the MHC is the extremely high levels of polymorphism found at loci. A diverse array of mechanisms have …
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Identification and characterization of a chicken major histocompatibility complex class II[beta] gene promoter
<p>The major histocompatibility complex (MHC) contains a variety of genes. Among them, the class II genes encode proteins involved in antigen presentation to helper T cells, a key step in initiating immune responses. The regulation of class II gene expression has been extensively studied in …
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Identification of Functional Immunological Indicators of Nutritional status during acute nutritional deprivation
… activity, major histocompatibility complex (MHC) class II expression, and fibronectin concentration were studied in 23 healthy cats during a 7 day period without food followed by a 7 day refeeding period. Blood samples were obtained for plasma fibronectin analysis and immune cell function …
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Isolation And Characterisation Of Immunoglobulin Gene Superfamily Molecules From Lower Vertebrates (Fish)
… is the major histocompatibility complex (MHC) restricted-cellular immune response. This involves several important elements including MHC molecules and T cell antigen receptor (TCR) complex. MHC molecules are glycoproteins that recognise and present self and foreign peptides to T-cells via …
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A role for HSC70 in regulating antigen trafficking and presentation during macronutrient deprivation
… loaded onto major histocompatibility complex (MHC) class II molecules for display and recognition by T lymphocytes. To examine the effect of macronutrient malnutrition on MHC class II antigen presentation, we grew B lymphocytes in media containing amino acids, sugars and vitamins but lacking …
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Superantigens as vaccine delivery vehicles for the generation of cellular immune responses
… to major histocompatibility complex (MHC) class II molecules and T cell receptors (TCRs). The resulting uncontrolled activation of up to 20% of all T cells and the subsequent cytokine release, can lead to fever, shock and death. Superantigens are not processed intracellularly like …
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Does variability matter? Major histocompatibility complex (MHC) variation and its associations to parasitism in natural small mammal populations
… such as the major histocompatibility complex (MHC) genes, is assumed to be a very powerful and effective tool to keep pace with diverse and rapidly evolving pathogens. In my thesis, I studied natural levels of variation at the MHC genes, which have a key role in immune defence, and parasite …
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Active Inhibition of T Cell Proliferation by Monocytes
<p>Monoclonal antibodies (mAb) to MHC class II molecules (anti-class II mAb) have been well described in their ability to inhibit T cell activation. The most current model is that anti-class II mAb interfere directly with the T cell receptor-major histocompatibility complex crosslinking which is …
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
… the direct (recognition of intact allogeneic MHC) and indirect (recognition of self-MHC restricted allopeptide) pathways make to allograft rejection remains incompletely understood. In this thesis, murine models of heterotopic cardiac transplantation have been utilised to analyse these …
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Identification of candidate tumour antigen peptides with immunogenic potential for use in cancer immunotherapy
… antigen in the context of peptide presented on MHC class II molecules, therefore recent research has focused on the identification of these peptides in order to formulate more effective immunotherapeutic strategies. As such, the aim of this study was to identify novel MHC class II HLA-DR1 and …
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Protective Immunity in Atherosclerosis
… Activation of the inhibitory Fcgamma receptor IIB (FcgammaRIIB) is an additional potential target for immune modulating therapy as hypercholesterolemic mice deficient in FcgammaRIIB have a more aggressive disease development. Antigen presentation is a fundamental step in T cell activation. By …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… enters the major histocompatibility complex: MHC) class II system for processing and presentation to CD4+ T cells. Experiments conducted by Michael Bevan in the 1970s demonstrated that exogenous antigen can also enter the MHC class I system and cross-prime CD8+ T cells; the process by which …
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Copper supplementation and monocyte function in growing beef calves
… had increased major histocompatibility complex (MHC) class II expression on d 68, 82 and 110 compared to CuSO₄-supplemented and control group heifers. Heifers supplemented with Cu had increased plasma Cu concentrations on d 82 and 110 compared to controls. The effect of vaccination on monocyte …
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Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation
… IL-1beta and major histocompatibility complex (MHC) class II mRNA expression in aged mice. Collectively, these studies showed that luteolin might be a promising agent for preventing neuroinflammation and neuronal cell death mediated by activated microglia and consequently, attenuating …
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