Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"MHC Class I"”.
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Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules
Major histocompatibility complex (MHC) class I molecules present fragments of the cellular proteome, in the form of short peptides, to the cell surface for the inspection by cytotoxic T cells. This process is a crucial immunosurveillance mechanism used to induce appropriate immune responses against …
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Associations between MHC class I variation and blood pathogen prevalence in caracal
… Genes of the Major Histocompatibility Complex (MHC) trigger the vertebrate adaptive immune response to pathogens through the recognition and presentation of foreign peptides, and thus provide an informative genetic marker for studying the adaptive potential of species with respect to disease. …
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Characterization of antigen processing and presentation by peptide-linked MHC class I molecules
MHC-Klasse-I-Moleküle präsentieren gewöhnlich Peptide, die aus zytosolischen Antigenproteinen durch proteasomalen Verdau generiert und anschließend vom TAP-Peptidtransporter ins endoplasmatische Retikulum transportiert werden. Es können jedoch auch endozytierte Antigene für die …
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Modulation of the T cell response with MHC class I peptides and their analogues
… outcome. T cell recognition of foreign MHC molecules plays a key role in initiating and sustaining allograft rejection. To prevent the risk of rejection, patients are given immunosuppressive drugs, which are non-specific and have major side-effects (infections, malignancies). It has been …
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Utilising recombinant TAPBPR technology to investigate MHC class I peptide editing and therapeutic applications
Major histocompatibility complex class I (MHC-I) molecules play a crucial role in the immune response to infection and malignancy by presenting peptides to CD8+ T cells. Optimal peptide:MHC-I complexes are generated in the MHC-I antigen processing and presentation pathway. In this pathway, TAPBPR …
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Conserved Non-Pocket Interactions Drive The Diversity of Peptide Presentation By Mhc Class I Molecules
… anchors. Several other HLA-I alleles and MHC molecules from different animal species also showed conservation of R65 and K66, in addition to D/E4 in bound peptide ligands, suggesting that charged interactions between D/E4 and R65/K66 represent a conserved, non-canonical pan-MHC-I anchor …
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MHC Class I diversity influences haematozoon infection intensity in the polymorphic black sparrowhawk (Accipiter melanoleucus)
The major histocompatibility complex (MHC) is a multigene family known to be the most variable gene group in vertebrates in terms of allelic diversity and gene number. Pathogen mediated selection is thought to be the major driving force behind the unusually high levels of MHC polymorphism in …
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MHC Class I Tyrosine Phosphorylation Site Y320 Augments CD8+ T Cell Priming, Effector Function, and Memory Response
<p>The cytoplasmic domain of MHC class I (MHC-I) molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a Y320F-mutated form of H-2K<sup>b</sup> had reduced capacity to generate K<sup>b</sup>-restricted cytotoxic T lymphocyte (CTL) …
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The role of nonclassical MHC class I products in the development and function of CD8+ T cells
Major histocompatibility complex (MHC) class I products present pathogen-derived peptides to CD8+ cytotoxic T cells. This interaction mediates the detection and clearance of intracellular infections. Emphasis has been placed on the critical role of classical class I MHC products in the development …
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The Cytoplasmic Tail of Mhc Class I Molecules Plays A Critical Role In Dendritic Cell-Induced T Cell Immunity
<p>The presentation of MHC class I (MHC-I)/peptide complexes by dendritic cells (DCs) is critical for the maintenance of central tolerance to self and for the regulation of cytotoxic T lymphocytes (CTL)-mediated adaptive immune responses against pathogens and cancer cells. Interestingly, several …
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Modulation of Ly49A+ Natural Killer Cell Licensing by Major Histocompatibility Complex Class I Alleles
… lymphocytes that react to cells lacking self-MHC: major histocompatibility complex) class I molecules, such as transformed or virally infected host cells and allogeneic bone marrow. This reactivity is mediated by inhibitory receptors for MHC class I that block the ability of activation …
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The degradation of membrane proteins from the mammalian endoplasmic reticulum
… factors influencing the catalyzed destruction of MHC class I molecules by the HCMV glycoproteins US2 and US 11 and the degradation of the model substrate TCRuc. The ER chaperone calnexin, implicated in glycoprotein folding, and the ER chaperones protein disulfide isomerase and Erolu, implicated in …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… enters the major histocompatibility complex: MHC) class II system for processing and presentation to CD4+ T cells. Experiments conducted by Michael Bevan in the 1970s demonstrated that exogenous antigen can also enter the MHC class I system and cross-prime CD8+ T cells; the process by which …
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CD8+ T Cells Are Required for the Therapeutic Action of Glatiramer Acetate in Autoimmune Demyelinating Disease
… but not IL-10, expression and activation by non-classical MHC class I molecules both in vitro and in vivo. GA-induced regulatory myeloid cells, previously shown to activate CD4+ regulatory T cells in an antigen-independent manner, depend on CD8+ T cells and MHC class I expression to suppress …
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Studies of Non-Classical Antigen Presentation Molecules: Functional Analysis of Mouse Qa-1 and Characterization of the Porcine CD1 Gene Family
"""Nonclassical"" major histocompatibility complex (MHC) class I-b molecules are structurally homologous with ""classical"" MHC class I-a molecules. Some MHC class I-b molecules appear to have a specialized antign (Ag) presentation role in given species. Two MHC class I-b molecules were studied, …
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The isolation and characterisation of MHC-presented peptides from CML-derived cell-lines, with a focus on post-translational modification
… kinase found in chronic myeloid leukaemia is a classic example. As phosphopeptides are known to be presented by both the MHC class-I and class- II pathways, against which specific CD4+ and CD8+ T cell responses may be generated, study of MHC-presented phosphopeptides may reveal unique cancer …
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