Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"MGUS"”.
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Assessing the psychosocial impact of monoclonal gammopathy of undetermined significance (MGUS)
… gammopathy of undetermined significance (MGUS) is a premalignant plasma cell disorder which precedes multiple myeloma (MM), an incurable blood cancer. To date, limited research has focused on the psychosocial impact of receiving a MGUS diagnosis. This dissertation reports the findings from …
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Genetic changes in the development of multiple myeloma
… gammopathy of undetermined significance (MGUS) to MM to the more aggressive plasma cell leukaemia (PCL). MGUS is the most common PC disorder and the majority of cases never progress to MM requiring treatment, as progression only occurs in ~1% of patients per year. From a genetic point of …
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An investigation of the role of ACTN1 in platelet formation and of platelet function in myeloma
… gammopathy of undetermined significance (MGUS). In the present study, multiparameter analysis of platelet activation and responsiveness was investigated by flow cytometry in patients with MGUS, SM/MM and healthy controls (HCs). The median platelet surface levels of CD63, annexin V and …
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Plasma Extracellular Vessicles, Exercise Resistnace and Cancer
… multiple myeloma of undetermined significance (MGUS). This analysis found that CD71 was upregulated in small and large EVs in individuals with MM relative to MGUS, suggesting that iron utilization and homeostasis in the tumor micro environment may play a role in disease progression. …
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Contribution of the Microenvironment in Bone Resident Cancer: the Role of Thrombospondin-1 in Bone and Risk Loci Contributing to Multiple Myeloma
… gammopathy of undetermined significance (MGUS). The C57Bl/KaLwRij (KaLwRij) mouse strain has increased susceptibility to benign idiopathic paraproteinemia (BIP), analogous to human MGUS, and is a common mouse model for the disease. Following immunization, KaLwRij mice developed a sustained …
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Η ανάπτυξη της ιξαζομίμπης από τα προκλινικά δεδομένα στις κλινικές μελέτες και την κλινική εφαρμογή
… μονοκλωνική γαμμαπάθεια αδιευκρίνιστης σημασίας (MGUS), μία καλοήθη πάθηση όσον αφορά την κλινική εκδήλωση, το ασυμπτωματικό ΠΜ (SMM), τη συμπτωματική – επιθετική διαταραχή του ΠΜ και την πιο επιθετική μορφή της, την πλασματοκυτταρική λευχαιμία με κυκλοφορούντα μυελωματικά κύτταρα στο αίμα. Το ΠΜ …
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Psychometric properties of the Satisfaction with life scale (SWLS) in a sample of individuals over the age of 40 years old from the Icelandic population
… gammopathy of undetermined significance (MGUS), which is a precursor to multiple myeloma. Individuals that provided informed consent were 78,581 and about half of those individuals completed at least one of the five self-report measures used in the current study. Results: The mean score on …
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MULTIPLE MYELOMA PLASMA CELL PROFILING: INTEGRATED SINGLE-CELL RNA AND VDJ SEQUENCING APPROACHES UNCOVER NOVEL CLINICAL INSIGHTS
… Monoclonale di Significato Indeterminato (MGUS) o Mieloma Multiplo Smouldering (SMM). Il MM presenta architetture clonali complesse e interazioni cruciali con il microambiente tumorale (TME). In effetti, la progressione della malattia è guidata dall’interazione disfunzionale tra la …
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DISSECTING THE CLINICAL AND BIOLOGICAL RELEVANCE OF DIS3 GENE IN MULTIPLE MYELOMA
… gammopathy of undetermined significance (MGUS), to extra-medullary plasma cell leukemia (PCL). Notably, MM is characterized by a deep genomic instability involving ploidy, structural rearrangements and a high range of mutations involving both putative oncogenes and tumor suppressor genes …