Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"MGMT"”.
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THE ROLE OF ACTIVE AND ACTIVE-SITE ALKYLATED HUMAN O6-METHYLGUANINE-DNA METHYTRANSFERASE (MGMT AND R-MGMT) IN DNA REPAIR AND BIOMONITORING
… antibodies raised against recombinant human MGMT were characterized and used to study the role of active and active-site alkylated human O6-methylguanine-DNA methyltransferase (MGMT and R-MGMT) in DNA repair and biomonitoring. The human DNA repair enzyme O6-methylguanine-DNA methyltransferase …
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NEW ADVANCES IN QUANTITATIVE RADIOLOGY: RADIOMICS IN NEURORADIOLOGY APPLIED TO PRIMARY BRAIN TUMORS USING A MACHINE LEARNING APPROACH
… radiomics analysis to predict IDH mutation and MGMT methylation status in gliomas Fabio M. Doniselli1,2, Riccardo Pascuzzo1, Eleonora Bruno3, Domenico Aquino1, Mattia Verri, Alberto Redolfi, Valeria Cuccarini1, Marco Moscatelli1,2, Maria Grazia Bruzzone1, Luca Maria Sconfienza2,4 Abstract …
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ANALYSIS OF TUMOR SPECIFIC PROTEIN EXPRESSION IN GLIOBLASTOMA MULTIFORME (GBMs) TUMORS THROUGH IMMUNOHISTOCHEMISTRY
… and O6-methylguanine-DNA-methyltrasnferase (MGMT) present, causing it to be more aggressive and less responsive to standard care. The objective of this study was to understand the correlation between IDH1 mutation presence and the expression of Basigin and MGMT. The expression of these …
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Metabolism of lomustine in dogs and comparative cytotoxicity of lomustine and its major metabolites and O6-methylguanine-DNA methyltransferase expression in canine cells
… enzyme O6-methylguanine-DNA methyltransferase (MGMT) causes resistance of tumor cells to bifunctional nitrosoureas, like lomustine. There is no data available regarding MGMT expression/activity in canine cells or tissues. Our study shows that there is low MGMT activity in the canine lymphoma …
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Monosacchacharid-Konjugate von Inhibitoren der O6-Methylguanin-DNA Methyltransferase, der Poly-(ADP-ribose) Polymerase und des SWITCH Phänomens des HIV Hüllproteins gp120 : Synthese, biologische Aktivität und Struktur-Wirkungsbeziehungen
… sind. So wurden O6-substituierten Purine zu MGMT-Inhibitor-Glucosiden, eine Hydroxyphenyl-benzimidazol-Grundstruktur zu PARP-Inhibitor-Glucosiden und Isochinolindion-Grundstrukturen zu SWITCH-Inhibitor-Glucosiden umgesetzt. Gegenüber dem 'Goldstandard' der MGMT-Inhibitoren, dem …
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Development of imidazotetrazines for the treatment of glioblastoma & as synthetic precursors to diazo species
… of O6-methylguanine DNA methyltransferase (MGMT) and loss of MMR function are the primary clinical modes of resistance to TMZ. Imidazotetrazine analogs modified at the N3 position were designed to deliver alternative DNA adducts that were irremovable by MGMT. An analog bearing a propargyl …
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Biological and Functional Consequences of Single Nucleotide Polymorphisms of the O6-Methylguanine-DNA-Methyltransferase Gene
… in the 06-Methylguanine-DNA-Methyltransferase (MGMT) gene, which repairs alkyl adducts at the 06-position of guanine, may be associated with an increased risk of lung cancer. However, the functional and biological significance of these SNPs has yet to be systematically characterized. We used two …
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Characterization of O6-Methylguanine DNA Methyltransferase and Base Excision DNA Repair Activity in Xiphophorous Fishes
… O9-methyl guanine DNA methyltransferase (06-MGMT). Xiphophorus fish provide an excellent system to study the heritable factors of tumorigenesis and carcinogenesis since inter-species cross are fertile and several select inter-species crosses produce progeny which show enhanced susceptibility …
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Design of a Validated Stability Indicating HPLC Method for the analysis of Patrin-2 (Lomeguatrib).
… It does so by blocking the action of ATase (MGMT), which repairs specific kinds of DNA damage and is particularly responsible for resistance to anti-cancer treatments. Patrin-2 acts as a pseudosubstrate inactivator of MGMT. It thus, helps Temozolomide proceed with it’s designed action, which …
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EVALUATING THE EFFECTS OF FASTING CONDITIONS IN COMBINATION WITH TEMOZOLOMIDE FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME
… O-6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein involved in TMZ resistance. Known as the Warburg effect, cancer cells will preferentially oxidize glucose to lactate in glycolysis. This less effective pathway of energy production means cancer cells must uptake …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… including O6 methyl guanine methyltransferase (MGMT) and mismatch repair (MMR). This thesis has identified analogues of TMZ (EA02-45, EA02-59, EA02-64 and EA02-65) that are MGMT and MMR independent in terms of inducing cell kill in vitro. These compounds are promising leads for future …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… including O6 methyl guanine methyltransferase (MGMT) and mismatch repair (MMR). This thesis has identified analogues of TMZ (EA02-45, EA02-59, EA02-64 and EA02-65) that are MGMT and MMR independent in terms of inducing cell kill in vitro. These compounds are promising leads for future …
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A clinicopathological and molecular genetic analysis of low-grade glioma in adults
… such as IDH1 and IDH2 mutation analysis, MGMT methylation analysis, copy number analysis using array comparative genomic hybridisation and identification of differentially expressed miRNAs using miRNA microarray analysis. IDH1 mutation was present at a frequency of 71% in low grade glioma …
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Implicaciones pronósticas de la relación subventricular en el gliobastoma multiforme: caracterización clínica, radiológica y patológica
… de los marcadores Olig2, PGFA, EGFR, p53, MGMT, NFP, IDH1 e YKL-40 sobre una muestra de 204 pacientes, estratificados por grupos ( I, II, III, IV y V) en función de la relación subventricular, los cuales a su vez se subdividieron en profundos (I, II, V) y superficiales (III y IV). Los GBMs …
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Glioma genetic profiling: The role of DNA repair and telomerase
… an inverse correlation between hTERT and MGMT expression was observed after treatment. Evidence shows that hTERT inactivation enhances sensitivity towards some chemotherapeutic agents, thus a combination of 5azadC with various chemotherapeutic agents proved to be more effective than …
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Characterising Heterogeneity of Glioblastoma using Multi-parametric Magnetic Resonance Imaging
… O6-methylguanine-DNA methyltransferase (MGMT) methylation status. For predicting 12-month PFS, the model of radiomic features and clinical factors outperformed the model of MGMT methylation and clinical factors (P = 0.010). In summary, pre-operative multi-parametric MRI shows potential …
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DNA methylation detection using an engineered methyl-CpG-binding protein
… hospitals evaluate the methylation status of the MGMT gene promoter to determine the best course of treatment for patients with glioblastoma. However, improved methylation detection techniques are required in order to expand the availability of such testing to more patients. Methyl-CpG-binding …
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The impact of cytotoxic chemotherapy on somatic mutation in normal human cells
… *O*-6- methylguanine-DNA methyltransferase (MGMT). Temozolomide exposure was shown to generate ten-fold higher SBS burdens in MGMT-knockout human induced pluripotent stem cells (hiPSCs) than in MGMT-wild-type hiPSCs, showing a different mutational signature depending on MGMT status. The …
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