Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MG-132"”.
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Mesenchymal Stem Cells Therapy in Progressive Rat Model of Parkinson's Disease
… vitro and progressive SD rat model of PD using MG-132, proteasome inhibitor. Immunocytochemical analyses in primary mesencephalic culture revealed that hMSC treatment increased dopaminergic neuronal survival compared to dopaminergic neuronal death in MG-132 treatment. Additionally, hMSCs …
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Role of ATG 5 in ER stress-induced apoptosis in meniscus.
… chaperone that alleviates ER stress or with MG-132, a proteasome inhibitor, restored normal levels of ATG 5. Taken together our data suggest that FFA palmitate induces ER stress in meniscus cells, decreases autophagy and promotes cell death. This is the first study to demonstrate that ER …
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HIJACKING OF CELLULAR PATHWAYS BY NOVEL TICK-BORNE PHLEBOVIRUS
… Pathway was inhibited using MG-132. Lastly, we observed that mutation of ubiquitination sites of RIG-I and TBK-1 prevented and reduced the interaction with SFTS virus NSs, respectively. Altogether, our study suggests a novel mechanism for dissemination and innate immune …
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Antitumor activity of antimalarials in human breast cancer cells
… to the growth medium. The proteasome inhibitors, MG-132 and lactacystin completely protected HDAC-1 from the action of quinidine. These data demonstrate that quinidine is a breast tumor cell differentiating agent that causes the loss of HDAC-1 via a proteasomal sensitive mechanism. Moreover, to …
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Einfluss der HMG-CoA-Reduktase-Inhibitoren Atorvastatin und Lovastatin auf die Regulation der Hepatischen Lipase
… derzeitigem Kenntnisstand am effektivsten durch HMG-CoA-Reduktase-Inhibitoren (Statine) gesenkt. <br>Die Hepatische Lipase (HL) hat wichtige Funktionen im Fettstoffwechsel. Sie ist beteiligt bei der Hydrolyse von Triacylglyzeriden und Phospholipiden der HDL2 zu antiatherogenen, cholesterinreichen …
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Expression of the repressor element-1 silencing transcription factor (REST) is regulated by IGF-I and PKC in human neuroblastoma cells
… exposed to PMA and the proteasome inhibitor MG132. In SH-SY5Y exposed to PMA and MG 132, we observed an inverse pattern of expression of synapsin I and β- tubulin III, two neuronal differentiation markers regulated by REST. Their cytoplasmic levels are reduced when compared to cells exposed …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
… with pre-treatment of the proteasome inhibitor MG-132. Mutants of FLIPs with ubiquitin-acceptor lysines mutated to arginine were generated and confirmed as ubiquitination sites in adherent, epithelial HCT116 colorectal cancer cells and 293T cells. Moreover, mutation of these lysines extended …