Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"METTL3 inhibitor"”.
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
… in ALCL. Single-agent use of tyrosine kinase inhibitors (TKI) to inhibit ALK is a conventional second-line treatment and has been trialled for upfront use in combination with the ALCL99 therapeutic backbone. However, an extended duration of treatment is required as cessation of therapy can …
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CRISPR AS A TOOL FOR TARGET DISCOVERY AND TECHNOLOGICAL INNOVATION: HIGH-THROUGHPUT CBE SCREENING TO EVALUATE M6A MODIFICATION PATHWAY IN CANCER PROLIFERATION AND DRUG RESISTANCE, AND INNOVATIVE PRIME EDITING STRATEGIES FOR DISEASE MODELLING AND THERAPY
… “writers”, including methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) that form a heterodimer regulated by the METTL-associated complex (MACOM). Its removal is mediated by “erasers”, including fat-mass and obesity-associated protein (FTO), while the methylated adenosines …