Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"METTL3"”.
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Role of Methyltransferase Like-3 (Mettl3) In Pancreatic Ductal Adenocarcinoma (Pdac) Progression
… to effectively combat PDAC. To that effect, METTL3-mediated post-transcriptional methylation of RNA transcripts have been shown to contribute to cancer progression in multiple cancer types.</p> <p>METTL3 deposits methyl groups onto adenosine bases within specific consensus sequences in RNA, …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
… N6-adenosine-methyltransferase 70 kDa subunit (METTL3). This enzyme catalyses N6-methyladenosine (m6A), the most abundant mRNA modification, through a complex with METTL14 and WTAP. Whilst METTL3 has been described as both an oncogene and a tumour suppressor gene in different cancers …
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Characterizing novel molecular regulators of antiviral gene expression
… by a cellular complex of proteins including METTL3 and METTL14 (METTL3/14) and other cofactors, and m6A can also be removed from RNA by the demethylase proteins FTO and ALKBH5. The presence of m6A on viral and host RNAs has been shown to influence the outcome of infection by diverse viruses. …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
… all seven components of the m6A writer complex (METTL3, METTL14, WTAP, VIRMA, RBM15, ZC3H13, and CBLL1) as top-ranking hits required for proper activation of the Caspase-2–MDM2–p53 axis. Functional experiments demonstrated that METTL3 catalytic activity is indispensable for MDM2 processing and …
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Structures and Regulation of the N6-Methyladenosine Methyltransferase METTL16
… for creating the m6A mark on mRNA are the METTL3/METTL14 heterodimer and METTL16. METTL3/METTL14 are responsible for most of the m6A modifications found on RNAs, whereas the specific activity of METTL16 on the SAM synthetase gene, MAT2A, modulates SAM homeostasis, implicating METTL16 as a …
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CRISPR AS A TOOL FOR TARGET DISCOVERY AND TECHNOLOGICAL INNOVATION: HIGH-THROUGHPUT CBE SCREENING TO EVALUATE M6A MODIFICATION PATHWAY IN CANCER PROLIFERATION AND DRUG RESISTANCE, AND INNOVATIVE PRIME EDITING STRATEGIES FOR DISEASE MODELLING AND THERAPY
… “writers”, including methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) that form a heterodimer regulated by the METTL-associated complex (MACOM). Its removal is mediated by “erasers”, including fat-mass and obesity-associated protein (FTO), while the methylated adenosines …
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Role of RNA methyltransferases in lung cancer
… I performed a late-stage study of METTL3, and I initiated and developed an early-stage analysis of THUMPD3. Advanced validation of METTL3, a well characterised m⁶A RNA methyltransferase, was performed based on the availability of a specific small molecule inhibitor, METTL3i. I …
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Exploring a Nuclear Insulin Receptor Signalling Pathway in Drosophila Neural Stem Cells
… out as being of particular biological interest. *Mettl3* encodes a conserved RNA methyltransferase. The m(6)A modification METTL3 catalyses is the most prevalent mRNA modification in vertebrates and influences mRNA stability, translational dynamics, and RNA pol II pause release. The latter is an …
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Single cell -omic landscapes in normal and perturbed haematopoiesis
… being recognised. The RNA methyltransferase METTL3 plays an important role in haematopoiesis and is an essential dependency in Acute Myeloid Leukaemia; small molecule inhibitors are currently in early phase clinical trials in cancer therapy, generating interest in the specific effects …
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Function and Mechanism of Alkbh5 In N6-Methyl-Adenosine Rna Modification In Glioblastoma
… installed by m<sup>6</sup>A methyltransferases METTL3 and METTL14 is erased by two members of the AlkB family of nonheme Fe(II)/a-ketoglutarate (a-KG)-dependent dioxygenases, fat-mass and obesity associated protein (FTO) or ALKBH5. ALKBH5 affects nuclear RNA export and metabolism, gene …
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ARCHITECTURE AND RNA RECOGNITION BY THE EUKARYOTIC M6A METHYLTRANSFERASE COMPLEX
… Kar4, Mum2, Vir1, and Slz1 (homologous to human METTL3, METTL14, WTAP, VIRMA, and ZC3H13). Using an integrative structural biology centred on cryo-electron microscopy, the organisation and stoichiometry of the ycMTC were elucidated. The 2.6 Å cryo-EM structure reveals a compact assembly with an …
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Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… degli mRNA oncogenici e la sua interazione con METTL3, una metiltransferasi coinvolta nella modifica post-trascrizionale. L'immunoistochimica e il Proximity Ligation Assay (PLA) hanno confermato la co-localizzazione di EIF3H e METTL3, supportando il ruolo dei geni Fitness-OverT nella promozione …
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Activin/Nodal Signalling Controls the Epigenome and Epitranscriptome of Human Pluripotent Stem Cells
… physically and functionally interacts with the METTL3-METTL14-WTAP complex to promote the formation of N6-methyladenosine (m6A). This epitranscriptional modification antagonizes the expression of selected mRNAs, including pluripotency factors whose transcription is promoted by SMAD2/3. …
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Investigation of m6A-regulated RNA-binding proteins
… recently described small molecule inhibitors for METTL3 (the primary m6A methyltrans- ferase) to perturb cellular m6A and study the effects on RNA-binding proteins in MOLM-13, an acute myeloid leukaemia (AML) cell line. This was coupled with the OOPS quantitative proteomics technique to directly …
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Genetic parameters and genomic analysis of semen quality and fertility traits in pigs
… DNAI2, IQCG, LOC102167830, NME5, AZIN2, SPATA7, METTL3 and HPGDS were identified associated with semen traits in the QTL regions identified for the pig lines evaluated. The gene network analysis showed candidate genes found for different pig lines sharing biological pathways that occur in …