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Showing 1 to 2 of 2 for “"METALATION (CHEMICAL REACTIONS)"”.

  1. Reinventing Aromatic Substitution: A Novel Look

    … substitution (EAS) and directed <em>ortho</em>-metalation (DoM) involve the direct substitution of an arene hydrogen. A major drawback involving EAS is the necessity for harsh forcing conditions for the reaction to proceed. Catalysts such as Lewis acids FeBr<sub>3</sub> and AICI<sub>3</sub> for …

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