Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"MERS-CoV"”.
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HUMAN DPP4/CD26 TRANSGENIC MICE AS SURROGATE MODELS FOR MERS
… Respiratory Syndrome caused by a coronavirus (MERS-CoV) and its proven transmissibility among humans constitute an ongoing public health threat. Animal models, especially small animal models that simulate human disease are needed for studies of pathogenesis and development of vaccines and …
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Structural and Molecular Basis for Multifunctional Roles of Cellular Proteases
… peptides such as signal peptides. Recent discoveries have begun to unravel their multifunctional roles in many other biological processes including blood pressure regulation and virus infection. However, the knowledge gathered thus far is still limited regarding the underlying mechanisms for …
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Coronavirus Proteases as Therapeutic Targets: Development of Biosensors to Detect Inhibition of Protease Activity and Separation of the Multiple Functions of Coronavirus Papain-Like Proteases
… on an international scale. The emergence of SARS-CoV and MERS-CoV highlight the need for research to identify antivirals and vaccines against coronaviruses. To develop therapeutics against current and potentially emergent coronaviruses, I utilized two approaches targeting the proteases encoded …
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BETACORONAVIRUSES OPTIMIZE REPLICATION BY BALANCING ANTAGONISM OF INNATE IMMUNE RESPONSES AND ER STRESS RESPONSES
… different disease outcomes in infected humans: HCoV-OC43, a common cold virus; MERS-CoV, which caused an epidemic of severe pneumonia in the Arabian Peninsula with a 36% case fatality rate; and SARS-CoV-2, the causative agent of the COVID-19 pandemic, which induces disease ranging from …
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Modeling Emerging Infectious Diseases for Public Health Decision Support
… Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and Ebola virus disease (EVD) outbreaks. This effort will provide quantitative, evidenced-based guidance for policymakers and public health responders to augment public health operations.
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Multifunctional Coronavirus Papain-Like Proteases as Targets for Antiviral Therapeutics and Vaccines
… Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle Ease Respiratory Syndrome coronavirus (MERS-CoV) pose a severe threat to humans because of high mortality. Despite the risk of coronavirus (CoV) emerging in the human population there are no antiviral drugs or vaccines to combat …
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Comparative Respiratory Tract Pathology of Emerging Viral Infections
… viruses in mammals that have yet to be discovered, some of which may affect humans. As humans continue to encroach upon previously isolated areas and have greater contact with wildlife, it is likely that zoonotic viruses will continue to emerge. Since many of these emerging viruses cause …
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
Human coronaviruses (HCoVs) have garnered intense interest due to the large outbreaks caused by severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which have …
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Understanding the determinants for substrate recognition, regulation of enzymatic activity and the development of broad-spectrum inhibitors of coronavirus 3-chymotrypsin-like proteases
… acute respiratory syndrome coronavirus (SARS-CoV) and the recently emerged Middle-east respiratory coronavirus (MERS-CoV). Coronavirus also impact global economy by infecting farm animals like pigs (porcine epidemic diarrhea virus, PEDV), cows (bovine coronavirus, BCoV) and poultry (avian …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
The global response to the COVID-19 pandemic and our inability to mitigate spread of SARS-CoV-2 has highlighted areas of research that warrant further study. RNA viruses have since been at the forefront for pandemic and prevention preparedness due to their increased potential to cause future …
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THE ROLE OF CORONAVIRUS - HOST CELL MEMBRANE INTERACTIONS DURING VIRAL ENTRY AS MEDIATED BY CONSERVED REGIONS OF THE FUSION PEPTIDE
… impact of coronavirus outbreaks such as SARS CoV-1 in 2002, MERS CoV in 2012, and the ongoing SARS-CoV-2 COVID19 pandemic, has highlighted the urgent need for a deeper understanding of coronavirus entry mechanisms to better predict and prevent future variants and pandemics. Central to viral …
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Computational Methods to Design Broad-Spectrum Medical Countermeasures Against Antigenically Diverse Pathogens
… antigens are predicted to have improved coverage of host and pathogen populations compared to existing wild types and computational designs. Experimental validation in mice confirmed these predictions, with the Spectravax nucleocapsid antigen being the first computationally designed …
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DEVELOPING SMALL-MOLECULE PROBES AND INHIBITORS FOR ADP-RIBOSE-BINDING PROTEINS
… GS-441524, an adenosine mimic known to bind SARS-CoV-2 Mac1. The optimized probes show hundreds to thousands-fold affinity increase for viral macrodomains, enabling cost-effective high-throughput screens. In Chapter 4, I constructed a focused library of GS-441524 derivatives in 96-well plates …
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Regulation of IRF-3-Dependent Innate Immune Signaling Pathway by the PLpro Domain of Non-Structural Protein 3 (NSP3) of Severe Acute Respiratory Syndrome (SARS) Coronavirus
… acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic virus that causes severe lung disease in humans and is associated with high mortality rates. SARS-CoV, like all other successful viruses, encode proteins that counteract the innate immune response. A number of reports …
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Evolution of targets at the host-pathogen interface
… Severe Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in particular – is presented. Chapter 2: Protein-coding potential of the Mtb genome <br>Using comparative genomics, I investigate the protein-coding potential of globally-distributed Mtb strains. Previous reports had suggested that the …
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Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
The recent SARS-CoV-2 pandemic highlighted the lack in pandemics preparedness for hCoVs potential future spillovers and for other (+)ssRNA viruses that still lack approved pharmacological treatments such as Flaviviruses. Small molecule development stands out as the most promising approach, as it …
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Structural and functional studies of the papain-like protease 2 from mouse hepatitis virus
… and deISGylating activities of coronavirus (CoV) papain-like protease domains (PLPs) are involved in virus immune evasion. To this end, we chose PLP2 from mouse hepatitis virus (MHV) as our target of study because MHV has historically served as a model system for the study of CoVs, and it has …
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