Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 61 for “"MERS"”.
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HUMAN DPP4/CD26 TRANSGENIC MICE AS SURROGATE MODELS FOR MERS
… Respiratory Syndrome caused by a coronavirus (MERS-CoV) and its proven transmissibility among humans constitute an ongoing public health threat. Animal models, especially small animal models that simulate human disease are needed for studies of pathogenesis and development of vaccines and …
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Middle East respiratory syndrome in the Kingdom of Saudi Arabia : insights from publicly available data
… 1300 cases of Middle East respiratory syndrome (MERS) have been diagnosed worldwide, the vast majority of which have occurred in Saudi Arabia and over 40% of which have ended in death. In Spring 2014, a large outbreak of MERS originated in the Kingdom of Saudi Arabia - concentrated in nosocomial …
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Templated synthesis of synthetic oligomers
… group towards the development of sequence oligomers equipped with H-bond donor and acceptor recognition units, which are able to assemble into duplexes by H-bonding between sequence-complementary oligomers. This thesis describes a new class of melamine oligomers composed of alternating triazine …
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Improving genome assembly by identifying reliable sequencing data
… k-mer counting helps to identify genomic k-mers from sequenced reads which may then inform read correction or genome assembly. Genome assembly has two major subproblems: contig construction and scaffolding. A contig is a continu- ous sub-sequence of the genome assembled from sequencing …
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Structural and Molecular Basis for Multifunctional Roles of Cellular Proteases
… Middle East respiratory syndrome coronavirus (MERS-CoV). To provide insights into the origin of MERS-CoV, I investigated the receptor usage and cell entry of MERS-CoV in comparison with HKU4, a related bat coronavirus. I discovered that DPP4 is also the receptor for HKU4. However, HKU4 failed …
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Hydrogen Bond Template-Directed Synthesis of Recognition-Encoded Melamine Oligomers
The directed evolution of biopolymers is based on the mutagenic replication of DNA. However, reliance on DNA limits the application of directed evolution to molecules that can be encoded by DNA, such as proteins. The development of a synthetic oligomer which can mutagenically replicate could unlock …
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Coronavirus Proteases as Therapeutic Targets: Development of Biosensors to Detect Inhibition of Protease Activity and Separation of the Multiple Functions of Coronavirus Papain-Like Proteases
… scale. The emergence of SARS-CoV and MERS-CoV highlight the need for research to identify antivirals and vaccines against coronaviruses. To develop therapeutics against current and potentially emergent coronaviruses, I utilized two approaches targeting the proteases encoded within all …
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BETACORONAVIRUSES OPTIMIZE REPLICATION BY BALANCING ANTAGONISM OF INNATE IMMUNE RESPONSES AND ER STRESS RESPONSES
… infected humans: HCoV-OC43, a common cold virus; MERS-CoV, which caused an epidemic of severe pneumonia in the Arabian Peninsula with a 36% case fatality rate; and SARS-CoV-2, the causative agent of the COVID-19 pandemic, which induces disease ranging from asymptomatic infection to severe …
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Global Microsatellite Content Potentially Distinguishes Humans, Primates, Animals, and Plants
… possible repetitive nucleotide motif from 1-mers to 6-mers, we examined 25 genomes. Here we show that global microsatellite content, as measured by array hybridization signal intensities, independently validates data from published sequence databases and is a sensitive and specific gauge of …
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Determining and characterizing immunological self/non-self
… this project, peptides of specific lengths (k-mers) are generated from each protein in the proteomes of various model organisms. The set of unique k-mers for each species is stored in a library and defines its "immunological self". Using the libraries, organisms can be compared to determine the …
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Multiple sequence recovery: theory and applications
… for DNA assembly and error correction use k-mers, or substrings of length k, of input sequences, we first consider the task of reconstructing multiple source strings from the complete collection of their k-mers; specifically, under what conditions on k and string length n can m strings be …
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Comparative genomics of repetitive elements between maize inbred lines B73 and Mo17
… were discovered. The B73 and Mo17 polymorphic k-mers were used to examine allele-specific expression of 45S rDNA in the hybrids. Although Mo17 contains higher copy number than B73, equivalent levels of overall 45S rDNA expression indicates that transcriptional or post-transcriptional regulation …
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Compressive algorithms for search and storage in biological data
… Sequencing data. By using the sparsity of k-mers of sufficient length in the human genome and imposing a human prior through the use of frequent k-mers in a large corpus of human DNA reads, we are able to quickly discard over 90% of the information found in those quality scores while …
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Modeling Emerging Infectious Diseases for Public Health Decision Support
… Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and Ebola virus disease (EVD) outbreaks. This effort will provide quantitative, evidenced-based guidance for policymakers and public health responders to augment public health operations.
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Replication of Sequence Information in Recognition-Encoded Synthetic Polymers
… by enzyme-catalysed polymerisation of monomers on nucleic acid templates and can be used in directed evolution processes to yield functional polymers. If directed evolution could be applied to synthetic oligomers, then new classes of functional polymers might be discovered. To reach this …
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Phenylacetylene oligomers as synthetic information molecules
… oligomer backbone. The AA, DD and AD 2-mers were synthesised and complementary 2-mers showed cooperative duplex formation. No intramolecular H-bonding due to folding was observed in the AD mixed 2-mer. Longer oligomers were synthesised using a method of oligomerisation and …
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Multifunctional Coronavirus Papain-Like Proteases as Targets for Antiviral Therapeutics and Vaccines
… Middle Ease Respiratory Syndrome coronavirus (MERS-CoV) pose a severe threat to humans because of high mortality. Despite the risk of coronavirus (CoV) emerging in the human population there are no antiviral drugs or vaccines to combat coronavirus infection. The focus of my dissertation was to …
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