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Showing 1 to 17 of 17 for “"MEP pathway"”.

  1. MMV008138 and analogs: potential novel antimalarial agents for P. falciparum

    Liu, LixuanVirginia Tech2018

    … pyrophosphate (DMAPP), via a non-mevalonate pathway: the methylerythritol phosphate (MEP) pathway. This pathway is not utilized by humans. Thus, compounds that target the MEP pathway and disrupt isoprenoid biosynthesis in P. falciparum hold promise as potent and safe new antimalarial agents, …

    vt Repository record

  2. Molecular target identification of antimalarial drugs using proteomic and metabolomic approaches

    Laourdakis, Christian DanielVirginia Tech2014

    … through the methylerythritol phosphate (MEP) pathway in the malaria parasite while humans utilize the mevalonate pathway. Therefore, the MEP pathway is a source of drug targets for drug development. Our group has identified MMV008138 as anti-apicoplast inhibitor through phenotypic …

    vt Repository record

  3. Rational Engineering of Expression Level of Multi-Gene Systems encoding Natural Product Biosynthesis in Streptomyces

    Hsu, Suzie2020

    … eight enzymes in the methylerythritol phosphate (MEP) pathway. One of the Design of Experiment (DoE) methods called Plackett-Burman design was used to guide the optimization effort for this eight-gene system. A five-level Plackett-Burman design was used to guide the design of 125 unique synthetic …

    umn Repository record

  4. Antimalarial Agents: New Mechanisms of Actions for Old and New Drugs

    Ghavami, MaryamVirginia Tech2018

    … parasites, the methylerythritol phosphate (MEP) pathway is known to be essential for its growth. This pathway is absent in humans, presenting the opportunity to develop potentially safe and effective therapeutic candidates. Previous work in the Cassera and Carlier lab had established that …

    vt Repository record

  5. The Synthetic Biology of N2-Fixing Cyanobacteria for Photosynthetic Terpenoid Production

    Halfmann, Charles T.2017

    … Engineered cyanobacteria with re-wired metabolic pathways have recently been designed through synthetic biology, and they possess the ability to synthesize new chemicals and biofuels, which are secreted from their cells. Terpenoids constitute one of the largest classes of organic molecules on …

    sdstate Repository record

  6. Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors

    Guerra, FranciscoUniversity of Illinois at Urbana-Champaign2015

    … inhibition of the Methyl Erythritol Phosphate (MEP; non-mevalonate pathway) pathway in bacterial and parasitic human pathogens and inhibition of isoprenoid synthases in human cancers. For the development of antibacterials and antiparasitics, this research investigates the structure, function, …

    uiuc Repository record

  7. Control of Substrate Supply to the Chloroplast 2-C-methyl-D-erythritol-4-phosphate Pathway

    Evans, Sonia Ebemen2025

    … chloroplast 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway supplies precursors for plastidic terpenoid biosynthesis, making it a focal point for manipulating terpenoid production in plants. The MEP pathway generates the universal terpenoid intermediates isopentenyl and dimethylallyl diphosphate …

    toronto-retro Repository record

  8. 1,3-Disubstituted-tetrahydro-β-carbolines: A New Method for Stereochemical Assignment and Synthesis of Potential Antimalarial Agents

    Cagasova, KristynaVirginia Tech2021

    … Malaria Box, targets an essential biosynthetic pathway (MEP pathway) of malaria-causing parasite Plasmodium falciparum. Analogs of 1a synthesized in our laboratory were found effective against multi-resistant Dd2 strain of P. falciparum which, together with an absence of MEP pathway in humans, …

    vt Repository record

  9. Optimization of Enantiopure tetrahydro-β-carbolines as Potent Antimalarials and Exploration of salicylic acid analogs for combating multidrug-resistant Neisseria gonorrhoeae

    AlMolhim, Hanan SulimanVirginia Tech2023

    … of inhibitors of the methylerythritol phosphate (MEP) pathway for isoprenoid precursor biosynthesis, since this pathway is essential for Plasmodium falciparum and absent in human. Application of the isopentenyl pyrophosphate (IPP) chemical rescue screen to the compounds of the Malaria Box, a …

    vt Repository record

  10. The relevance of bacterial isoprenoid biosynthetic pathways for host-microbe interactions

    Nolan, James A.University College Cork2014

    … of two bacterial isoprenoid biosynthetic pathways (Mevalonate (MVAL) and 2-C-methyl-D-erythritol 4-phosphate (MEP)) for host-microbe interactions. We determined a significant reduction in microbial diversity in the murine gut microbiota (by next generation sequencing) following oral …

    cork Repository record

  11. Localization of monoterpenoid indole alkaloid (MIA) biosynthesis by in situ hybridization (ISH)

    Edmunds, ElizabethBrock University2013

    … all MIAs, secologanin, is produced through the MEP pathway occurring in two cell types, the IPAP cells (Gl0H) and epidermal cells (LAMT and SLS). The work presented in this thesis, localizes a novel enzymatic step, UDPG-7-deoxyloganetic acid glucosyltransferase (UGT8) to the IPAP cells of …

    brock Repository record

  12. Novel Antimalarial Compounds from the Optimization of the Malaria Box

    Ding, ShaVirginia Tech2020

    … target of MMV008138 is the PfIspD enzyme in the MEP pathway, which is absent in humans. This difference makes the PfIspD a great target. However, while MMV008138 shows potency against Plasmodium falciparum-infected human erythrocytes in vitro, no efficacy was observed in a humanized mouse model …

    vt Repository record

  13. Metabolic engineering for the production of functionalized terpenoids in heterologous hosts

    Edgar, Steven McBrideMassachusetts Institute of Technology2017

    … allows for increased control over biosynthetic pathways enabling improved yields, titer, and productivity. The anti-cancer molecule Taxol (Paclitaxel) stands as one of the most medically and economically important terpenoids. However, despite decades of extensive study, its biosynthesis remains …

    mit Repository record

  14. GENOMIC AND MICROBIOME ANALYSIS TO IMPROVE FILLET YIELD AND QUALITY TRAITS IN RAINBOW TROUT

    AHMED, RIDWAN OLAWALE2025

    … and shotgun metagenomics to identify taxa and pathways predictive of fillet color. Fish with red fillets were enriched (LDA score > 1.5) for Leuconostoc lactis, Corynebacterium variabile, Jeotgalicoccus halotolerans, and Leucobacter chromiireducens—bacterial species with known probiotic …

    maryland Repository record

  15. Further Exploring the Structure Activity Relationship (SAR) of MMV008138 and MMV1803522

    Li, HaiboVirginia Tech2023

    … enzyme PfIspD in the methylerythritol phosphate (MEP) pathway. This compound shows good in vitro potency against the drug resistant Dd2 strain of Plasmodium falciparum. However, this lead showed no activity in mouse models. This lack of activity may be due to poor metabolic stability of the …

    vt Repository record

  16. Novel Antimicrobial Development by Targeting the First Two Committed Enzymes in the Methyl Erythritol Phosphate Pathway, DXP Reductoisomerase and MEP Cytidylyltransferase

    Haymond, Amanda Nicole2017

    gmu

  17. Hit to Lead Stage Optimization of Orally Efficacious β-Carboline Antimalarials

    Mathew, JopaulVirginia Tech2023

    … identified MMV008138 as an inhibitor of the MEP pathway, which produces essential isoprenoid precursors (IPP and DMAPP) in the malaria parasite P. falciparum (EC50 250 ± 70 nM, IPP rescue 100% @ 2.5 μM). Subsequent investigation revealed that (1R,3S)-configuration and 2',4'-dihalogen …

    vt Repository record