Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"MEN1"”.
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Attitudes About Predictive Men1 Genetic Testing In Minors
<p>Multiple Endocrine Neoplasia type 1 (MEN1) is a hereditary cancer syndrome characterized by tumors of the endocrine system. Tumors most commonly develop in the parathyroid glands, pituitary gland, and the gastro-entero pancreatic tract. MEN1 is a highly penetrant condition and age of onset is …
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The role of Men1 in pituitary gland tumourigenesis
… multiple endocrine neoplasia (MEN) syndromes. MEN1 is one of these inherited syndromes. People suffering from MEN1 develop tumours of the pituitary gland, the parathyroid glands, the pancreatic islets and the adrenal glands. MEN1 is caused by a loss of function mutation in the tumour suppressor …
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Identification of MEN1 loss-off function as a potential biomarker for immune checkpoint therapy
… checkpoint therapy. It was found that loss of MEN1 led to increased PD-L1 expression, as well as upregulated expression of the cytokines CXCL10 and CCL5. MEN1 is a TSG encoding the 68kDa protein menin, which has a range of poorly defined functions including an association with …
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Developing a novel Drosophila model to study Menin biological function
Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant tumour predisposition syndrome caused by loss-of-function mutations in the MEN1 gene, which encodes the scaffold protein Menin. Menin regulates transcription through interactions with histone deacetylases, histone …
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Identification of novel genetic vulnerabilities and therapeutic targets in acute myeloid leukaemia using CRISPR dropout screens
… have validated selected genes using DOT1L, BCL2, MEN1 and many other genes genetic and pharmacological inhibition, and chose candidates for downstream studies. Both the epigenetic modifier KAT2A and SRPK1 as promising KAT2A and spliceosome kinase SRPK1 inhibition demonstrated anti-AML activity by …