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Showing 1 to 1 of 1 for “"MEK5 CYCLOPHILIN SIGMA SMALL MOLECULES DESIGN SYNTHESIS"”.
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Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions
<p>Cyclophilin A are a class of peptidyl-prolyl isomerases that catalyzes isomerization of the proline residue within a protein. Cyclophilin A plays an instrumental role in the pathogenesis of HIV and HCV virus. Using structure-based drug we designed and synthesized small molecule inhibitors of …