Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"MEK1/2 inhibitors"”.
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
The RAS-RAF-MEK1/2-ERK1/2 signalling pathway is one of the most frequently deregulated pathways in human cancer, with mutations in KRAS and BRAF commonly occurring in cancers of the pancreas, skin, and colon, among others. Indeed, BRAF and MEK1/2 inhibitors are approved for the treatment of …
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Combinatorial Modulation of Multiple Signaling Pathways to Gain Therapeutic Response in Breast and Prostate Cell Carcinomas
… from our group have shown that UCN-01 and MEK1/2 inhibitors interact to cause tumor cell death in transformed cell lines in vitro. We extended this observation to an in vivo animal model system using the estrogen dependent breast cell carcinoma line MCF-7 and the estrogen independent breast …
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Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions
… drug we designed and synthesized small molecule inhibitors of cyclophilin A. These inhibitors were biologically evaluated for their ability to inhibit WT HIV-1 inhibition.</p> <p>Mitogen-Activated Protein Kinase signaling cascades plays a critical role in cancer cell survival, metastasis, and …
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ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… undergo BIM-dependent cell death in response to MEK1/2 inhibitors when combined with BH3-mimetics such as ABT263, small molecules that inhibit pro-survival proteins of the apoptotic pathway. The RSK1/2 protein kinases, immediate downstream targets of ERK1/2, have also been implicated in the …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… activity of MMPs is tightly controlled by tissue inhibitors of MMPs (TIMPs). TIMPs are specific endogenous molecules, which by binding to pro-MMPs inhibit the activation of MMPs. Imbalance between production of MMPs and TIMPs plays an important role following stroke [137, 138]. Pfefferkorn and …