Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 160 for “"MEK"”.
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Pharmacological effect of MEK inhibitors on plasmodium falciparum
… modules comprising the MAPK and upstream MAPKKs (MEKs) and MAPKKKs (MEKKs). Surprisingly, experimental and in silico analyses have demonstrated P. falciparum does not possess any MEK homologues, even though its kinome comprises two members of the MAP kinase family. Prior to the finding that the …
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Investigating the Anti-Melanoma Activity of Combinatorial Paclitaxel and MEK Inhibitor
Melanoma has increased considerably over the past forty years. Traditional and newly-developed anti-melanoma drugs do not produce a satisfactory therapeutic response for the treatment of late stage melanoma. Nanomedicine is a potent tool for clinicians to circumvent many of the existing …
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Conversion of methyl ethyl ketone (MEK) to valuable chemicals over multifunctional supported catalysts
… conversion of bio-derived methyl ethyl ketone (MEK) into different useful chemicals. The first part discusses the direct conversion of MEK to butene over supported copper catalysts (Cu-Al₂O₃, Cu-zeolite Y sodium (Cu-ZYNa) and Cu-zeolite Y hydrogen (Cu-ZYH)) in a fixed bed reactor. In this …
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REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS
… pathway involving the concerted action of Ras/Mek/Erk pathway, Focal adhesion kinase (FAK) and Protein phosphatase-2A (PP2A) to activate DLC1s GAP function. EGF stimulation not only leads to the phosphorylation of DLC1 but also that of FAK to inactivate it, thus allowing PP2A-mediated …
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Design and Synthesis of CDK-5 and MEK-5 Inhibitors and Synthesis towards Tubulysin Analogs
… of CDK-5 were designed and synthesized. </p><p>MEK-5, a member of the MAPK family, phosphorylates ERK-5 permitting cells to survive oxidative stress. MEK-5 is upregulated in tumor cells and activated by mitogens; inhibition of this enzyme is a potential anti-cancer strategy. Scaffolds from the …
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Régulation de la prolifération et de la différenciation des cellules épithéliales intestinales par les cascades MEK/ERK et AMPc/PKA
… de cascades de signalisation intracellulaires, MEK/ERK et AMPc/PKA, dans la prolifération et la différenciation des cellules épithéliales intestinales. Dans un premier temps, nous avons montré que la cascade MEK/ERK est nécessaire mais non suffisante à la prolifération des cellules épithéliales …
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The Kras/Mapk Pathway and Ligand Independent Activation of Erα: Implications For The Treatment of Endometrial Cancer
… which was restored following treatment with a MEK inhibitor.</p> <p>To address the functional consequence of differential estrogen signaling expression of estrogen induced genes and cell viability assays were evaluated. Following treatment with a MEK inhibitor, mutant KRas cells had increased …
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Systems modeling of quantitative kinetic data identifies receptor tyrosine kinase-specific resistance mechanisms to MAPK pathway inhibition in cancer
… cell lines up-regulate many RTKs in response to Mek inhibition, although reported with conflicting mechanisms. Upon integrated analysis, we find both Axl and Her2 have increased lysate levels after Mek inhibition with 3 Mek inhibitors, Selumetinib, Binimetinib, and PD0325901. Axl changes are …
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Mechanistic Basis of Signal Amplitude Modulation by the Ras Effector IMP
The RAF/MEK/MAP Kinase signal transduction cascade is the most extensively studied MAPK pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. The Ras effector and E3 ligase family member IMP (Impedes …
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Genetic analysis of innate immunity in Caenorhabditis elegans
… to pathogen infection. Here, I will discuss a mek-1 suppressor screen that was performed to look for more components of the p38 PMK-1 pathway. Aided by the agls219 reporter, mutants with high levels of GFP expression were isolated and screened for suppression of the Esp phenotype of mek-1. …
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Die Rolle mitogener und stressinduzierter MAPK-Signalwege in der Regulation von keratinozytären Wachstums- und Differenzierungsvorgängen
… raschen und transienten Aktivierung des Raf/MEK/Erk- (MAPK-) Signalweges verbunden ist, während keine veränderte Aktivität der stressinduzierten MAPK Jnk und p38 nachweisbar war. Die calciuminduzierte Erk-Aktivierung unterschied sich in ihrer Kinetik von mitogener Erk-Aktivierung durch den …
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The effect of oxygenates on the oligomerisation of propene over zeolite ZSM-5
… acid, ethanol, butanol, methyl-ethyl-ketone (MEK), acetone and water. Complex feeds can result in competitive reaction between the feed components and may result in observed selectivities that cannot be predicted from pure component data alone. ZSM-5 has been shown to be an excellent catalyst …
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… downstream effector proteins of KRAS, such as MEK inhibitors, have failed to produce significant clinical benefits. Previous studies by our group on the metastatic process revealed that malignant lung cancer cells undergo an epithelial-to-mesenchymal transition (EMT) that is regulated by a …
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Erk1 and Erk2 in hematopoiesis, mast cell function, and the management of Nf1-associated leukemia and tumors
… effectors of canonical Ras-Raf-Mek signaling. Thus, Erk represents a potential regulator of leukemogenesis and tumor-associated inflammation. However, single and combined Erk1 and Erk2 roles in HSC function, myelopoiesis, and mature mast cell physiology remain unknown, and recent …
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Uncovering the Complexity of RAS Signaling Networks
The Raf/MEK/MAP Kinase signal transduction cascade is a key Ras effector pathway that mediates diverse cellular responses to environmental cues, and makes a major contribution to Ras-dependent oncogenic transformation. Here we describe two important aspects to understanding the signaling complexity …
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The Role of p66Shc in Stem Cells: Signalling, Identity and Apoptosis
… pluripotency even in the absence of chemical MEK/GSK3β inhibition. These effects are consistent with a model in which p66Shc acts as a competitive inhibitor of Grb2 recruitment, restraining ERK–STAT3 signalling to promote lineage priming. In NSCs, p66Shc loss conferred resistance to apoptosis …
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Influence de la protéine Pumilio 2 sur le phénotype sénescent induit par les oncogènes
… est soumise à un stress. Les oncogènes Ras et MEK entrainent, au sein de la cellule, une sur-activation de la voie des MAP Kinases, impliquée dans la prolifération cellulaire. L’induction de ce stress mitotique est connue pour induire la sénescence cellulaire. La protéine Pumilio 2 est un …
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A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death
… downstream pro-survival signaling with the MEK inhibitor U0126 rescued the C4-2 cells from resveratrol-induced death, however other MEK inhibitors did not recapitulate this response. In fact, U0126 acted independently of MEK, inhibiting mitochondrial function and shifting cells to aerobic …
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Role of Extracellular Signal-Regulated Kinase (ERK) in Regulation of Intestinal Epithelial Tight Junctions
… was determined by evaluating the effect of MEK inhibitor (U0126) on: a) the phosphorylation and translocation of PKCζ and PP2A, b) the association of PKCζ and PP2A in occludin immunocomplex in under-differentiated and differentiated Caco-2 cell monolayers, and c) by <em>in vitro</em> …
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Scaffold-Mediated Organization of Signal Transduction Networks
The Raf-MEK-ERK kinase cascade is a highly conserved signal transduction module involved in cellular processes ranging from proliferation and differentiation to transformation and apoptosis, and is engaged in response to growth factors, cytokines, morphogens, and other extracellular stimuli. Given …
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