Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"MEF2C"”.
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The Role of MEF2 Transcription Factors in Neocortical Circuit and Synapse Development In Vivo
… pathways is unknown. I report that MEF2A, MEF2C, and MEF2D non-redundantly regulate synapse development onto individual pyramidal neurons within layers 2 and 3 (L2/3) of the postnatal mouse primary somatosensory "barrel" cortex in vivo. Simultaneous deletion of Mef2a and Mef2d modestly …
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Experience-Dependent and Input-Specific Regulation of Neocortical Circuit Development by Genes Linked to Neurodevelopmental Disorders
… 1 (Fmr1) and myocyte enhancer factor 2c (Mef2c) in the postnatal experience-dependent development of input-specific synaptic connections. I report that postnatal, cell-autonomous deletion of Fmr1 in postsynaptic L2/3 or L5 neurons results in a selective weakening of AMPA receptor-, but not …
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The Interaction of Early Growth Response Gene 1 and Myocyte Enhancer Factor 2C in the Murine Brain Cortex
… may interact with myocyte enhancer factor 2C (MEF2C), which is known to be involved in many similar processes as EGR1, such as synapse architecture, cell migration, and learning and memory. EGR1 and MEF2C ChIP-seq data derived from mouse frontal cortex suggest these two proteins may regulate a …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… with cardiogenesis. Myocyte enhancing factor 2C (Mef2c), a transcription factor involved in development of cardiac structure and cardiomyocyte differentiation, has been shown to increase in response to in utero VPA exposure. Furthermore, this increase in gene expression has been associated with …
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Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… by inducing HDAC4/5 nuclear translocation and MEF2C inhibition. Recently, Scriptaid, an HDAC complex inhibitor, has been shown to induce Mef2 expression and exercise-like adaptation in mouse muscles. In myocytes, Scriptaid disrupts the HDACs co-repressor complex and induces nuclear export of …
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Multifunctional Regulators of Cardiac Disease and Development
… of Mef2 genes and skeletal defects present in Mef2c +/-; Mef2d +/- mice, I hypothesized that MEF2is an important regulator of skeletogenesis and generated mice lacking MEF2C and MEF2D in chondrocytes using Mef2c and Mef2d conditional mutant alleles. From this study, I demonstrated that MEF2 …
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The myocyte enhancer factor-2 (MEF2) family mediates complex gene regulation in skeletal and cardiac myocytes
… a requirement for MEF2A and -D, but not MEF2C in cardiomyocyte survival. Comparative microarray analysis confirmed that, similar to skeletal myoblasts, the MEF2 family regulated distinct but overlapping gene programs in cardiomyocytes. Additionally, this analysis uncovered a previously …
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MOLECULAR DEFECTS OF MEF2 FAMILY PROTEINS AND NAC PROTEINS THAT BLOCK MYOGENESIS AND PROMOTE TUMORIGENESIS IN RHABDOMYOSARCOMA
… in vivo by xenograft assay. We also have found MEF2C is deregulated in rhabdomyosarcoma with the aberrant alternative splicing. We have shown that exon α in MEF2C is aberrantly alternatively spliced in RMS cells, with the ratio of α2/α1 being highly downregulated in RMS cells compared with …
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ROLE OF G9A IN SKELETAL MYOGENESIS
… gene promoters. It also associates with MEF2C, a transcription factor essential for sarcomere gene expression, and enhances the interaction with co-repressor HDAC5. This occurs through blocking of calcium signalling-dependent phosphorylation and cytoplasmic export of HDAC5. Furthermore, …
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DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS INTO CARDIOMYOCYTES
… (HDFs) when working together with GATA4, MEF2C, TBX5, HAND2 and MYOCD (5F). HDFs-generated iCMs exhibited cardiac-like action potential and spontaneously contractility in-vitro. Importantly, SALL4, together with 5F, promotes adult human cardiac fibroblasts (aHCFs) into cardiac-like cells. …
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Myogenic Effectors and Disease
… by controlling the transcription factor Mef2c. In contrast, global deletion of the Kelch protein Klhl41 in mice causes severe nemaline myopathy, including neonatal lethality and aggregation of contractile proteins in muscle, particularly Nebulin. Molecularly, Klhl41 acts as a chaperone …
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The effects of virus-induced maternal inflammation on methylation patterns in skeletal muscle
… in PRRSV piglets, including FcγRII, MEF2C, citrate synthase, and PRKAB2. Additionally, genes from several disease response pathways were hypermethylated, along with genes from the thyroid hormone signaling pathway and oxidative phosphorylation pathway, possibly affecting myosin heavy …
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miR-322/503 Cluster Drives Cardiac Differentiation by Inhibiting CUG-binding Protein 1
… of cardiac transcription factors (Tbx5, Mef2C, Nkx2-5 and α-MHC); and (3) inhibitors of miR-322 and miR-503 significantly reduced expression of α-actinin and the above cardiac TFs. Remarkably, miR-322/503 regulates the cardiac program by inhibiting an RNA-alternative splicing/decay …
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Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… and activation of the transcription factor MEF2C. These data demonstrate that GluN3A negatively regulates NMDAR-dependent activation of gene transcription and reveal a novel mechanism that regulates the level of NMDAR-induced transcriptional response in the developing brain. In the second …
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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction
… increased cardiac gene expression (GATA-4, Mef2C, and Nkx-2.5) when compared to ESCM and control cells. Based on the in vitro findings, we investigated the effect of intramyocardial delivery of TIMP-1 on endogenous CD63+ve/c-kit+ve cells following myocardial infarction (MI). C57BL/6 and …
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Molecular Regulation of Direct Cardiac Reprogramming
… by cardiac transcription factors [Gata4, Hand2, Mef2c, and Tbx5 (GHMT)], we screened 192 protein kinases and discovered that Akt/protein kinase B dramatically accelerates and amplifies this process in three different types of fibroblasts (mouse embryo, adult cardiac, and tail tip). Approximately …
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Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
The MEK5/ ERK5 kinase module is a relatively new discovered mitogen-activated protein kinase (MAPK) signalling pathway with a poorly defined physiological function. Since ERK5 and its upstream activator MEK5 are abundant in skeletal muscle a function of the cascade during muscle differentiation was …
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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… disrupted binding of transcription factor MEF2C and local chromosome accessibility as confirmed by ChIP-Sanger-seq and ATAC-seq. Although it was previously reported that IGF2BP1 expression was significantly higher in ETV6-RUNX1 ALL as well as other cancers, the underlying transcriptional …