Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"MEF2 Transcription Factors"”.
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The Role of MEF2 Transcription Factors in Neocortical Circuit and Synapse Development In Vivo
… development requires postnatal experience and transcription. Neocortical neurons migrate to their proper layers and then undergo robust synapse proliferation to maximize contacts with presynaptic partners. Synapses are dynamic structures subjected to an equilibrium of formation and elimination …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… a novel role for Vav guanine nucleotide exchange factors (GEFs) in brain-derived neurotrophic factor (BDNF)-dependent synapse plasticity. BNDF and its receptor, TrkB, are well-established positive modulators of hippocampal long-term potentiation (LTP), and increasing evidence suggests that …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… identity. I am interested in determining the transcription factors downstream of calcineurin and other calcium-regulated signaling pathways in the control of myofiber specialization. By analyzing two fiber type-specific enhancers, I was able to demonstrate that there are functional NFAT …
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Multifunctional Regulators of Cardiac Disease and Development
… thesis, I present my findings on two cardiac transcription factors MEF2 and Yap that play multiple roles in development. First, I show a novel function of myocyte enhancer factor 2 (MEF2) transcription factors in development of endochondral bone. MEF2 proteins are widely known as essential …
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Discovery of New Regulatory Proteins and Mechanisms in Muscle Biology and Disease
In an effort to discover new regulators of muscle function, we identified a novel muscle-specific protein, Klhl40. Genetic deletion of Klhl40 in mice results in a nemaline myopathy-like phenotype with disruption of sarcomere function causing neonatal lethality. Nemaline myopathy (NM) typically …
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Genome-wide identification of enhancers, transcription factors, and mechanisms that control skeletal muscle differentiation in cattle
… of this dissertation project was to identify transcription factors, enhancers, and mechanisms that control gene expression during skeletal muscle development and growth on a genome-wide scale. Three independent studies were conducted in this project. The objective of the first study was to …