Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"MEF2"”.
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Roles of HDACs and MEF2 in Adult Hippocampal Neurogenesis
… HDAC binding partner, myocyte enhancer factor 2 (MEF2). Using conditional knockout (cKO) mice and in vitro cell culture, I show that histone deacetylase 3 (HDAC3) is required for the proliferation of adult NSPCs. Detailed cell cycle analysis of NSPCs from Hdac3 cKO mice reveals a defect in cell …
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MEF2-regulated Gtl2-Dio3 noncoding RNAs in cardiac muscle and disease
The MEF2 transcription factor is a central regulator of skeletal and cardiac muscle development. Recently, we showed that MEF2A regulates skeletal muscle regeneration through direct regulation of the Gtl2-Dio3 microRNA mega-cluster. In addition to their expression in skeletal muscle, temporal …
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Cognitive resilience is mediated by the MEF2 network in mice and humans
Recent increases in human longevity have been accompanied by a rise in the incidence of dementia. While a large proportion of aged individuals display pathological hallmarks of neurodegenerative disease, a small number of these individuals are able to maintain healthy cognitive function even in the …
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The Role of MEF2 Transcription Factors in Neocortical Circuit and Synapse Development In Vivo
… activity-dependent Myocyte Enhancer Factor-2 (MEF2) transcription factors - MEF2A-D - have distinct but overlapping expression profiles throughout the brain and typically suppress synapse number. The cell-autonomous role for specific MEF2 genes in neocortical circuit development has never been …
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The myocyte enhancer factor-2 (MEF2) family mediates complex gene regulation in skeletal and cardiac myocytes
… by an array of transcription factors. MEF2 is a crucial transcription factor required for muscle differentiation, but the roles of the individual MEF2 family members, MEF2A-D, have not been extensively evaluated. Acute ablation of Mef2 expression in skeletal myoblasts revealed a …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… NFAT (nuclear factor of activated T cells) and MEF2 (myocyte-specific enhancer factor 2) binding sites within the enhancer of troponin I slow, and both sites are required for slow fiber specific activity of this enhancer. Next, I identified MEF2 as a target of calcineurin in cultured myogenic …
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MOLECULAR DEFECTS OF MEF2 FAMILY PROTEINS AND NAC PROTEINS THAT BLOCK MYOGENESIS AND PROMOTE TUMORIGENESIS IN RHABDOMYOSARCOMA
… these cells that block myogenesis. We have found MEF2D is absent in RMS cell lines representing both major subtypes of RMS and primary cells derived from an embryonal RMS mice model. We have shown that the down regulation of MEF2D is a major cause for the failure of RMS cells to differentiate. We …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… this study reports the identification of common MEF2 and FMRP mRNA targets that are required for MEF2-induced synapse elimination. The activity-dependent transcription factor myocyte enhancer factor 2 (MEF2) is a key negative regulator of excitatory synapse number, promoting synapse removal in …
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Involvement of p300 in caffeine-induced hyper-acetylation of histones at the MEF2 binding domain on the Glut4 gene
Includes abstract. Includes bibliographical references.
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Postembryonic Development and Adult Plasticity of the Mushroom Bodies in the Honey Bee Brain
… transcription factor myocyte enhancer factor 2 (MEF2) is used to label a specific subpopulation of mushroom body neurons. MEF2 expression is first seen in newborn cells that are just beginning neuronal differentiation. The cloned honey bee MEF2 homolog is highly conserved with respect to …
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Multifunctional Regulators of Cardiac Disease and Development
… my findings on two cardiac transcription factors MEF2 and Yap that play multiple roles in development. First, I show a novel function of myocyte enhancer factor 2 (MEF2) transcription factors in development of endochondral bone. MEF2 proteins are widely known as essential regulators of development …
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Roles of Class II Histone Deacetylases in the Cardiovascular System
… factors, including myocyte enhancer factor 2 (MEF2). Using gene targeting combined with biochemical assays, the function and regulation of class II HDACs are being elucidated. Here I show that in the absence of HDAC5, the heart becomes profoundly enlarged in response to calcineurin signaling …
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Fragile X Mental Retardation Protein Induces Synapse Loss Through Acute Postsynaptic Translational Regulation
… of FMRP with the transcription factor MEF2. MEF2 activity in wild-type neurons induces robust synapse loss; however, MEF2 fails to decrease synapse number in Fmr1-KO neurons. A dominant-negative form of MEF2 increases synapse number in WT, but not Fmr1-KO neurons. Finally, when …
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The roles of Cabin1 and Left1 in T cell development
… binds calcineurin and myocyte enhancer factor 2 (MEF2) through the C-terminal region. In cell lines, these interactions inhibit calcineurin activity following TCR signaling and transcriptional activation of Nur77 by MEF2. The role of these interactions in vivo was investigated using a mutant mouse …
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Regulation of skeletal muscle glucose transporter 4 expression in fructose-fed exercised rats
… and binding of the myocyte enhancer factor- 2A (MEF2A) transcription factor to its binding domain on the Glut4 gene promoter, the impact of fructose consumption on this interaction has not been studied. Moreover, there is no direct evidence that an increase in MEF2 binding is due to increased …
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Genomic studies of motif enrichment and conservation in the regulation of gene expression in the brain
… associated with the transcription factor family MEF2, some of whose members are known to play a role in synapse development. Data from chromatin immunoprecipitation and tiling-microarray (ChIP-on-chip) experiments [11 have isolated peaks of specific binding by MEF2 in developing rat brains. …
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Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… by inducing HDAC4/5 nuclear translocation and MEF2C inhibition. Recently, Scriptaid, an HDAC complex inhibitor, has been shown to induce Mef2 expression and exercise-like adaptation in mouse muscles. In myocytes, Scriptaid disrupts the HDACs co-repressor complex and induces nuclear export of …
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Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
… the outcome of transcriptional control for MEF2-dependent genes. I use a combination of biochemical approach with fluorescence imaging techniques to study the regulation of epigenetic re-programming mediated by PKD and HDAC5 in adult cardiac myocytes during hypertrophy and heart failure.</p>
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Role of JAK3 in Myogenic Differentiation
… (MGN), MyoD, and myogenic enhancer factor 2 (MEF2). Knockdown of the JAK3 gene using siJAK3 also significantly increased MHC, MGN and MyoD mRNA expressions as well as insulin-like growth factor-II (IGF-II) gene expression. During differentiation, JAK3 was initially activated and later …
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Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
… transcription factor myocyte enhancer factor 2 (MEF2), which is involved in stress response and cardiomyocyte remodeling. MuRF1 is required for AMPK-mediated protein degradation through the UPS in cardiomyocytes. Consequently, the absence of MuRF1 during chronic fasting preserves cardiac …
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