Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MED12"”.
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Med12 Is A Critical Regulator of Neural Crest Lineage and Nervous System Myelination
… to the eukaryotic transcription machinery. MED12 is a Cdk8- regulatory kinase module subunit directly implicated in human disease and is genetically altered in neurological disease and cancer. Numerous attempts at generating an<em> in vivo</em> system to study the role of Med12 failed due to …
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… CARM1, including Mediator Complex Subunit 12 (MED12) and the lysine methyltransferase KMT2D/MLL2. Both of these proteins are implicated in enhancer function. We identified the primary CARM1-mediated MED12 methylation site as arginine 1899. Using methyl-specific antibodies to this site, we found …
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Identifying Novel Interaction Between CDK8 Kinase Module and The Deubiquitinating Enzyme Ubiquitin Specific Protease 7 (USP7)
… Kinase 8 (CDK8) and Mediator Complex Subunit 12 (MED12), components of the kinase module in the Mediator complex, contain consensus sequences for binding to the N-terminus of USP7. Using various co-immunoprecipitation, pulldowns, tissue culture, and western blotting related techniques, our …
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Mechanisms of Transcriptional Control by the Mediator Complex Subunit Cdk8
… it resides in a dissociable module with CycC, Med12, and Med13. Cdk8 regulates transcription by phosphorylating transcription factors in response to environmental signals. However, the full extent of all Cdk8 substrates and the mechanisms by which Cdk8 itself is regulated are not completely …
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The Role of PRICKLE1 in the Regulation of Uterine Structure and Physiology
… Animal models, including the Eker rat and MED12-mutated mice, provide valuable insights in UL but have significant limitations. Genetic animal models that faithfully represent gene expression changes seen in UL and recapitulate UL phenotype are lacking. Our lab had previously developed two …
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Persistent Oxidative Damage Accounts for the Origin of Mutations Observed in Uterine Pathology
… hysterectomy. Leiomyomas are known to contain MED12 codon 44 mutations at high frequency, involving all 6 possible guanine substitutions in the codon GGT. We show that myometrium is persistently exposed to peroxynitrite, as is endometrium. Oxidative guanine damage, promoted by peroxynitrite …
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Identification of Tissue and Circulating Biomarkers For Premalignant and Malignant Lesions
… NALCN, LRP1B, FAT4, ATM, TMPRSS13, SOX9, CSMD3, MED12</em>) which constantly served to separate adenomas from adenocarcinomas were discovered.</p> <p>The Second project focused on exploring differentially expressed genes (DEG) and pathways enriched with such genes in colorectal adenomas and …