Global ETD Search
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Showing 1 to 20 of 43 for “"MED/26 Neurologia"”.
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Aspetti cognitivi dell'epilessia frontale notturna
… sintomi psichiatrici. Lo studio ha un follow up medio di 20 anni e riporta, per la prima volta in letteratura, lâ��evoluzione clinica dei soggetti che hanno avuto un esordio dellâ��epilessia in età evolutiva. Fino ad ora, lâ��epilessia frontale notturna è stata associata a disfunzioni cognitive …
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Studio dei ritmi circadiani in pazienti in stato vegetativo
… Results: In all patients LCF and DRS confirmed vegetative state. All patients showed a sleep-wake cycle. All patients showed spindle or spindle-like activities. REM sleep was detected in only 7 patients. Patients displayed a greater fragmentation of nocturnal sleep due to frequent …
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Sonno e funzioni cognitive: ruolo della microstruttura del sonno NREM
… A series of neuropsychological tests were performed by the subjects in the morning and afternoon of the second day (D2am; D2pm) and in the morning of the third day (D3am). Raw scores from the neuropsychological tests were used as dependent variables in the statistical analysis of the results. …
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Criteri di valutazione medico-legale della narcolessia
… 1. the interobserver reliability among Italian Medical Commissions making disability and handicap benefit decisions for people with narcolepsy, searching for correlations between the recognized disability degree and patients’ features; 2. the willingness to report patients to the driving licence …
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Revisione critica dei risultati e nuovi algoritmi decisionali sulla chirurgia dell'OSAS
… deficiency. Surgeries in these cases are aimed at reducing the bulk of the tongue base or providing more space for the tongue in the oropharynx so as to limit posterior collapse during sleep. These procedures include tongue-base suspension, genioglossal advancement, hyoid suspension, …
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IMPATTO DELLA DEPRESSIONE SUL RISCHIO DI PROGRESSIONE DEL MILD COGNITIVE IMPAIRMENT A MALATTIA DI ALZHEIMER
The depression symptoms in the elderly may accompany mild cognitive impairment. The aim of this study was to evaluate the role of depression on the risk of evolving to Alzheimer disease (AD) among mild cognitive impairment (MCI) subjects. We present the results of a clinical study of 169 MCI. …
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SPINAL MUSCULAR ATROPHY ORGANOIDS REVEAL DEVELOPMENTAL DEFECTS RESCUED BY ANTISENSE OLIGONUCLEOTIDES TREATMENT
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by mutations in the SMN1 gene. Recent therapies have significantly modified SMA natural course, but treatment efficacy remains variable and the reasons beyond this variability are still largely unexplored. Identifying pre-symptomatic …
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IN VIVO AND IN VITRO EVALUATION OF THE COMBINATION OF RNA INTERFERING AND GENE THERAPY FOR TREATING MITOFUSIN2-RELATED DISEASES
Background: Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein essential for mitochondrial networking in most cells. Autosomal dominant mutations in the MFN2 gene cause Charcot-Marie-Tooth type 2A disease (CMT2A), a severe and disabling sensory-motor neuropathy. Here, we propose a novel …
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AGE-RELATED GUT DYSBIOSIS ACCELERATES THYMIC INVOLUTION AND ALTERS PERIPHERAL T CELL REPERTOIRE IN DUCHENNE MUSCULAR DYSTROPHY
Emerging researches highlight a significant interplay between the immune system and skeletal muscle, particularly in the context of inflammatory muscle disorders and dystrophic conditions like Duchenne Muscular Dystrophy (DMD), as well as during the natural process of muscle regeneration. …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
Aggregation of α-synuclein protein in “Lewy bodies” and “Lewy neurites” and dopaminergic neuronal loss in the nigrostriatal system are the key neuropathological hallmarks of Parkinson’s disease. Mutations in GBA1, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s …
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