Global ETD Search
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Showing 1 to 20 of 100 for “"MED/04 Patologia generale"”.
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Stenodactilina e lanceolina: due nuove potenti “ribosome-inactivating proteins” bicatenarie. Purificazione, caratterizzazione chimico-fisica e studio dei meccanismi citotossici
Two lectins, called lanceolin and stenodactylin, were purified by affinity chromatography on CL Sepharose 6B from the caudices of the Passifloraceae Adenia lanceolata and Adenia stenodactyla, respectively. They are glycoproteins with Mw of 61,243 (lanceolin) and 63,131 daltons (stenodactylin), …
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Zinco, invecchiamento e sistema immunitario: effetti sull'apoptosi e sulla proliferazione dei linfociti
… life may have negative effects later in life: named “Antagonistic Pleyotropy Theory of Ageing”. Data obtained in this work indicate an higher and faster expression of MTs with lower doses of zinc in total lymphocytes, in CD4+ and in CD8+ T lymphocytes from old subjects supporting the antagonistic …
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CHARACTERIZATION OF GENETIC AND EPIGENETIC MODIFICATIONS IN A MODEL OF INFLAMMATION-DRIVEN CANCER
Chronic inflammation is causally associated to many types of tumor, and has been recently acknowledged as a cancer hallmark. Nevertheless, whether inflammation has an intrinsic mutagenic potential is still not directly proven or understood from a mechanistic point of view. Furthermore, it is as yet …
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NOVEL APPROACHES IN GENETIC VARIANT DISCOVERY AND CLASSIFICATION TACKLING UNSOLVED PROBLEMS IN CANCER CLINICAL GENOMICS
… diagnosis and targeted therapy in personalized medicine. However, variant classification is a complex process that requires the integration of multiple, often incomplete sources of information, prompting the development of bioinformatic tools that enable clinicians to prioritize mutations for …
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REDEFINING PROMOTER DNA METHYLATION CHANGE IN CANCER
Promoter DNA methylation has been recognized for decades as one of the major mechanisms of epigenetic gene regulation and has consistently been found to be perturbed during cancer development. However, among the many genomic regions that have been found to display altered methylation in different …
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