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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"MECHANISMS OF GENE REGULATION"”.
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In silico approaches to investigating mechanisms of gene regulation
Identification and characterization of regions influencing the precise spatial and temporal expression of genes is critical to our understanding of gene regulatory networks. Connecting transcription factors to the cis-regulatory elements that they bind and regulate remains a challenging problem in …
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Methods for identifying regulatory grammars
… technology have made it possible to study the mechanisms of gene regulation, such as protein-DNA binding, at greater resolution and on a greater scale than was previously possible. We present an expectation-maximization learning algorithm that identifies enriched spatial relationships between …
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Predicting enhancer regions and transcription factor binding sites in D. melanogaster
… important to the fundamental biological problem of understanding the mechanisms through which a regulatory sequence drives specific spatial and temporal patterns of gene expression in early development. The modENCODE project aims to comprehensively identify functional elements in the C. elegans …
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Causation and Explanation in Molecular Developmental Biology
The aim of this dissertation is to provide an analysis of central concepts in philosophy of science from the perspective of current molecular and developmental research. Each chapter explores the ways in which particular phenomena or discoveries in molecular biology influences our philosophical …
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Automation of Drosophila gene expression pattern image annotation : development of web-based image annotation tool and application of machine learning methods
… hybridization screens are providing an abundance of spatio-temporal patterns of gene expression data that is valuable for understanding the mechanisms of gene regulation. Drosophila gene expression pattern images have been generated by the Berkeley Drosophila Genome Project (BDGP) for over 7,000 …
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H-NS Counter-silencing as a Primary Regulatory Mechanism of Curli Gene Expression in Salmonella Typhimurium
Incorporation of horizontally acquired genes into transcriptional networks is essential for regulated expression of virulence in the bacterial pathogen Salmonella enterica serovar Typhimurium. The nucleoid-associated protein H-NS is able to recognize and bind AT-rich horizontally acquired genes, …
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Dissecting Transcriptional Regulatory Networks with Systems Biology Approaches
… such as the DNA microarray and ChIP-on-chip have generated a large amount of high-throughput data for biologists. Although these data has provided us systems-level information about gene regulation, a major challenge in systems biology is to derive methodologies that will infer the underlying …
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Towards causality in gene regulatory network inference
Understanding the coordination of biomolecules that underlies gene regulation is key to gaining mechanistic insights into cellular functions, phenotypes, and diseases. Advances in single-cell technologies promise to unveil mechanisms of gene regulation at unprecedented resolution by enabling …
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Sex-dependent and Sex-independent Gene Regulation after Peripheral Nerve Injury
Peripheral nerve injury (PNI) induces cascades of gene expression changes in the central nervous system (CNS). However, there are still many uncertainties regarding the mechanisms of gene regulation that are sex-dependent and sex-independent. In this study, I examined the sex differences and …
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Physiological role and quantitative aspects of human Nonsense-mediated mRNA decay (NMD)
… mRNA decay (NMD) is a molecular pathway of mRNA surveillance that ensures the rapid degradation of mRNAs containing premature translation termination codons in all studied eukaryotes. Originally, NMD was thought of as a quality control pathway that targets non-functional mRNAs arising …
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Regulation of Chromatin Landscape on and by the Human Sex Chromosomes
… constitution is the largest and oldest source of genetic variation in the human population. One sex chromosome—the “active X” (Xa)—is present in all individuals. The second sex chromosome differs between sexes; most males have a Y while most females have a second X, which adopts a distinct …
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Determinants of GATA1-mediated gene regulation during erythroid maturation
… and lineage decision-making. Within this branch of development, erythropoiesis is the process through which mature red blood cells arise from progenitor cells. In this context, GATA1 is widely considered to be the master transcription factor for erythropoiesis, controlling the expression of a …
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Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation
… elucidates several independent molecular mechanisms that function in astrocytes and glial tumor cells, and suggest that developmental and inflammatory signals may contribute to the development of brain tumors. First, we analyzed the mechanism of TIMP-1 activation in astrocytes and …
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Genome-wide Predictive Simulation on the Effect of Perturbation and the Cause of Phenotypic variations with Network Biology Approach
… technologies such as microarray-based gene expression profiling, a large amount of molecular profile data have been generated in several disease related contexts. Despite the fact that these data likely contain systems-level information about disease regulation, revealing the underlying …
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Characterization of the VtlR regulons in Brucella abortus and Agrobacterium tumefaciens
… and plants, respectively. These bacteria are genetically similar and are found within the same Class, Alphaproteobacteria, and Order, Rhizobiales, of the domain Eubacteria; however, they survive and replicate in vastly different environmental niches. In Order to adapt to different …
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ΕΠΙ ΤΗΣ ΕΝΕΡΓΟΠΟΙΗΣΕΩΣ ΤΗΣ ΕΜΒΡΥΙΚΗΣ ΑΙΜΟΣΦΑΙΡΙΝΗΣ ΕΙΣ ΤΟΝ ΕΝΗΛΙΚΟΝ
… TO ADULT HEMOGLOBIN PRODUCTION, BUT TRACE AMOUNT OF FETAL GLOBIN EXPRESSION CAN BE DETECTED THROUGHOUT THE ADULT LIFE. KNOWLEDGE OF THE MECHANISMS OF REGULATION OF GLOBIN GENE EXPRESSION IS VERY INTERESTING BECAUSE OF THE ELACIDATION OF THE PHENOMENON AND THE PRACTICAL APPLICATION IN THE VARIOUS …