Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"MDSCs"”.
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Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs
Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous immune population found within the tumour microenvironment (TME). We sought to explore the potential role of microenvironment components on the suppressive behaviour, development and maintenance of MDSCs, focusing mainly on the role of …
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The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture, MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, and B1 cell IgE Production.
… of myeloid derived suppressor cells, MDSCs. ADAM10Tg MDSCs function synonymous to tumor MDSCs. Of the two subpopulations of MDSCs, granulocytic MDSCs increase parasitic clearance in a model of N. brasiliensis. Monocytic MDSCs are more immunosuppressive in regards to tumor. Both …
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Biomarkers in sepsis and other severe infections
… cells, myeloid-derived suppressor cells (MDSCs) were found in patients with sepsis; Mo-MDSCs were preferentially expanded in patients with gram-negative sepsis, whereas granulocytic MDSCs (PMN-MDSCs) accumulated in patients with gram-positive sepsis. We conclude that the immune response …
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Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis
… monocytic myeloid-derived suppressor cells (Mo-MDSCs). The gene-expression profile of cancer-derived monocytes was remarkably similar to that of reprogrammed immunosuppressive monocytes from patients with gram-negative sepsis. This suggests that Mo-MDSCs may be generated in a similar manner in …
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Immunological mechanisms controlling chronic inflammatory diseases
… function of myeloid derived suppressor cells (MDSCs) in TAZ10mice. MDSCs accumulate in lymphoid and non-lymphoid organs of TAZ10 mice during acute phases of inflammation and their number decrease as inflammation is fading. Despite their strong inhibitory function on T cell function and …
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Role of Properdin in Tumour Growth and Cell Recruitment
… the immune profile of tumour bearing<br/>mice. MDSCs, C5a, CCL2, TGF-β and mRNA FOXP3 were significantly less<br/>abundant in tumours of properdin deficient compared to wildtype mice. Protein<br/>levels for CCL2, a chemokine associated with tumour progression, was higher in<br/>wildtype tumour …
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Immunotherapeutic Strategies to Reverse Tumor Associated Immunosuppression in Breast Cancer
… high levels of myeloid derived suppressor cells (MDSCs) in the spleen and lymph nodes of immunized mice. For the first time, we demonstrated that by eliminating G-CSF in ATCVs, the overall efficacy of the vaccine can be significantly improved. Further, for the first time, by using breast cancer …
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Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer
… cells comprise Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) and can suppress T cells via production of immunosuppressive factors. Conversely, efficient cytotoxic T cell priming is dependent on the ability of antigen-presenting cells (APCs), mainly conventional …
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… <p>Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immunosuppressive myeloid cells that are involved in cancer progression and therapeutic resistance. In this work, we demonstrated the essential role of MDSCs in PTEN-deficient prostate cancer (PCa). We revealed …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… sustaining myeloid-derived suppressor cells (MDSCs) via IL-4 and IL-13, thereby suppressing anti-tumour interferon-γ (IFNγ), Th1 and CD8+ T cell-mediated immunity. Notably, therapeutic blockade of IL-25-signalling decreased tumour ILC2s, MDSCs and cancer burden, while enhancing anti-tumour …
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Intratumoral Sting Activation Sensitizes Poorly Immunogenic Cancers to Checkpoint Blockade Immunotherapy
… (TAMs) and myeloid derived suppressor cells (MDSCs) to support rather than suppress T cell activity, converting CRPC and PDAC to settings in which checkpoint blockade can be effective. To this end, we established therapeutic synergy between cyclic dinucleotide (CDN) STING agonists and …
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
… (TAMs) and myeloid derived suppressor cells (MDSCs). In addition, VISTA expression is increased on tumor-infiltrating regulatory T cells (Tregs) compared to those in the periphery. VISTA has been shown to suppress effector T cells through multiple mechanisms, primarily by inhibiting activation …
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Targeting PI3K Isoforms to Improve Effectiveness of T Cells Mediated Immunotherapy
… growth, improve T cell infiltration, and reduce MDSCs in PTEN-present tumors. However, we observed limited synergistic effects of PI3KB inhibitor and ICB in PTEN-present tumors. Multiomics profiling revealed the upregulation of TNF-a signaling in PTEN-present tumors and the upregulation of genes …
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Bacterial outer membrane vesicles (OMVs) as a platform for personalized cancer vaccines
… (Tregs) and myeloid-derived suppressor cells (MDSCs). We have also shown in the same mouse model that vaccination with OMVs engineered with two TSAs have a synergistic protective activity in controlling tumor growth. Finally, we have demonstrated that therapeutic OMV vaccines targeting five …
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Identification and Analysis of Omentum Derived Suppressor Cells in Regards to Th17 Inhibition
… (MSCs) and myeloid derived suppressor cells (MDSCs). Activated omentum exhibited anti-inflammatory properties through suppression of Th1 and Th17, while promoting tolerance through expansion and survival of Tregs. The mechanism of Th17 inhibition relied on IFNɣ-mediated upregulation of …
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Differential gene expression in Behcet's disease and differential anti-tumor effects of Tim3 pathway blocking molecules
… frequency of myeloid derived suppressor cells (MDSCs) in splenocytes of mice on 21 day after tumor challenge. These results indicate that Tim3V domain alone is not sufficient for tumor growth suppression but is in the presence of its fusion partner of immunoglobulin CH2CH3.
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Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
… activation of T cells and decreased Tregs and MDSCs. This microenvironment remodeling correlated with complete tumor elimination. Altogether, Delta-24-RGDOX activates the IDO-Kyn-AhR cascade, identifying new targets, which when inhibited have the potential to enhance anti-glioma effects of …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
… cells than tumor-bearing mice. Tyk2-/- MDSCs have a slight increase in suppression of T cell proliferation. Since elevated phosphorylation of Stat3 has been seen in human and murine breast cancer, and expression of Stat3 in the mitochondria (mitoStat3) appears to have important affects …
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