Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"MDSC"”.
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Hypoxia Activated Prodrug and Anti-Angiogenic Therapy Cooperate to Treat Pancreatic Cancer But Elicit Immune Suppressive G-Mdsc Infiltration
… granulocytic myeloid derived suppressor cells (G-MDSC) into treated tumors potentially responding to increased tumor-intrinsic release of the chemokine CCL9. Blockade of the CCL9 cognate receptor, CCR1, was found inhibit G-MDSC migration towards TH-302 and VEGFR-2 blockade treated tumor …
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IMPACT OF L-ARGININE TRANSPORTATION ON MYELOID-DERIVED SUPPRESSOR CELL FUNCTION
… inflammation. Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that expand during benign and cancer-associated inflammation. MDSC are characterized by their ability to potently inhibit T cell responses. Therefore, by dampening inflammation, MDSC benefit …
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Doxorubicin and T Helper Lymphocytes: Unexpected Allies Against Cancer
… (Treg) and myeloid-derived suppressor cells (MDSC). MDSC expand in tumor-bearing hosts and play a central role in cancer immune evasion by inhibiting adaptive and innate immunity. Different approaches have been explored to negatively impact MDSC, each associated with specific pitfalls. In this …
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Type 1 Interferon: A Negative Regulator Of Myeloid-Derived Suppressor Cells Function In Cancer
Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils and monocytes with potent immune suppressive activity. These cells play an important role in tumor progression and limit the efficacy of cancer therapies. Whereas many pathways stimulate the generation of MDSC, the key …
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The impact of myeloid derived suppressor cells on vaccine immunogenicity in South African HIV-infected and uninfected mothers and their infants
… that myeloid-derived suppressor cells (MDSC) that might be induced during gestation, would persist at birth leading to active suppression of infant-immune responses. OBJECTIVE: We evaluated the ontogeny of MDSC and the effect of MDSC on vaccine immunogenicity during early life in South …
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On strong reduction in director string calculus
… a modified version of director string calculus (MDSC). The algebra simplifies the implementation of the MDSC while preserving the applicative structure of the originalexpression, and capturing strong reduction.
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Physical Aging, Solubility, and Water Activity of Selected Disaccharides
… SDSC, and the total and reversing heat flows in MDSC slightly increased with longer aging times and the Tg calculated for SDSC decreased whereas Tg calculated for MDSC slightly increased with aging time. In experiment two, maltose glasses aged at the $\rm Tg - 20\sp\circ C$ took longer to …
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Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer
… cells comprise Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) and can suppress T cells via production of immunosuppressive factors. Conversely, efficient cytotoxic T cell priming is dependent on the ability of antigen-presenting cells (APCs), mainly conventional …
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The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture, MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, and B1 cell IgE Production.
… of myeloid derived suppressor cells, MDSCs. ADAM10Tg MDSCs function synonymous to tumor MDSCs. Of the two subpopulations of MDSCs, granulocytic MDSCs increase parasitic clearance in a model of N. brasiliensis. Monocytic MDSCs are more immunosuppressive in regards to tumor. Both …
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Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… modulated differential scanning calorimetry (MDSC). FLT SDs were characterized by powder X-ray diffraction (PXRD). Molecular interactions were determined using infrared and Raman spectroscopy and molecular modeling using Jaguar. Polymer precipitation inhibition efficiency and dissolution …
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Immunotherapeutic Strategies to Reverse Tumor Associated Immunosuppression in Breast Cancer
… high levels of myeloid derived suppressor cells (MDSCs) in the spleen and lymph nodes of immunized mice. For the first time, we demonstrated that by eliminating G-CSF in ATCVs, the overall efficacy of the vaccine can be significantly improved. Further, for the first time, by using breast cancer …
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Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs
Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous immune population found within the tumour microenvironment (TME). We sought to explore the potential role of microenvironment components on the suppressive behaviour, development and maintenance of MDSCs, focusing mainly on the role of …
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Imunologiniai atvirų ir laparoskopinių prostatos vėžio operacijų skirtumai /
… NK, CTL. Also the immunosuppressive compartment (MDSC) did not reveal any upregulation in the postoperative period once the LPR technique was applied, Conversely, Open Radical Prostatectomy (ORP) was associated with the absence of CTL postoperative restoration as well as the suppressor compartment …
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Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… modulated differential scanning calorimetry (MDSC). Thermal analysis i.e. glass transition temperature (Tg), crystallinity and melting point depression along with theoretical calculations such as solubility parameter were performed to study drug polymer miscibility. Molecular interactions were …
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Comparing the thermal decomposition kinetics of cane and beet sucrose to examine thermal behavior differences
… from quasi-isothermal (QI) and nonisothermal MDSC experiments were examined. For QI-MDSC experiments, the Ea values determined for all sucrose sources from t1/2 values matched those determined using the isothermal isoconversional method at 50% α. The agreement of the Ea values indicates that …
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Computation in director string calculus
… a modified version of Director String Calculus (MDSC) which preserves the applicative structure of the original lambda terms and captures the strong reduction as opposed to weak reduction of the original Director String Calculus (DSC). Furthermore, our reduction system provides an environment …
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… <p>Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immunosuppressive myeloid cells that are involved in cancer progression and therapeutic resistance. In this work, we demonstrated the essential role of MDSCs in PTEN-deficient prostate cancer (PCa). We revealed …
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Papel de la translocación bacteriana en la modificación de las poblaciones linfoide, mieloides supresoras y de células dendríticas en enfermos infectados por vih
… infectados por el VIH. El porcentaje de MDSC fue similar en pacientes y controles, pero la expresión intracelular de IL-10 fue significativamente mayor en pacientes. El logro de una carga indetectable de VIH después de la terapia no modificó los parámetros de translocación bacteriana, …
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Investigating the loss of crystal structure in carbohydrate materials
… modulated differential scanning calorimetry (MDSC), quasi-isothermal MDSC and TGA. Using regular MSDC did not yield any meaningful signals outside of total heat flow. The equations used to calculate the regular MDSC signals could not be applied during the loss in crystal structure event, since …
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