Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"MDR1"”.
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Targeting mdr1 and endocrine therapy-resistant cancers through estrogen receptor
… to inactivating multidrug resistance protein 1 (MDR1) in therapy resistant breast and ovarian cancer cells was developed. To evaluate the effectiveness of BHPI in reversing multidrug resistance in vivo, multidrug resistant OVCAR-3 ovarian cells, that are resistant to all known anticancer agents, …
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Role of the Vitamin D Receptor in MDR1/P-glycoprotein Regulation at the Blood-brain Barrier
The blood-brain barrier (BBB) presents a major obstacle for drugs targeting the brain. Drugs that are small or lipophilic enough can penetrate the physical barrier, but are commonly effluxed back into the blood by transporters that are expressed at the luminal membrane, notably P-glycoprotein …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… expression of multi drug resistance protein 1(MDR1, also known as P-glycoprotein or P-gp). MDR1's role in altering uptake, distribution and bioavailability is considered a significant factor when examining drugs for clinical administration, and represents a viable drug target for the reversal …
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4-ISOXAZOLYL-1,4-DIHYDROPYRIRINES BIND THE MULTIDRUG-RESISTANCE TRANSPORTER
… expression of multi drug resistance protein 1(MDR1, also known as P-glycoprotein or P-gp). MDR1's role in altering uptake, distribution and bioavailability is considered a significant factor when examining drugs for clinical administration, and represents a viable drug target for the reversal …
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Regulation and functional significance of ATP binding cassette transporters in human placenta
… multidrug resistance gene product 1 and 3 (MDR1 and 3)/ABC subfamily B members 1 and 4 (ABCB1 and 4), multidrug resistance associated proteins 1 and 2 (MRP1 and 2)/ABCC1 and 2 and breast cancer resistance protein (BCRP)/ABCG2 was initially studied in term human placenta, cultured primary …
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Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
… with multidrug resistant (MDR) efflux proteins (MDR1 and MRP2) over-expressed on retinoblastoma tumor. Ocular cells have shown good tolerability against antimicrobial moxifloxacin (fourth generation fluoroquinolone) at higher dose level. As majority of fluoroquinolones become ineffective due to …
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Understanding the Mechanism of Action of Rituximab in the Reversal of Multidrug Resistance in a Non-Hodgkins Lymphoma Cell Line
… drugs were determined using Namalwa/MDR1 and three drug-sensitive cells. Finally, the iv distribution of P-gp and CD20 in membranes was monitored after treatment with MAbs by western blot analysis. We found that RTX inhibited the function of the P-gp pump while other anti-CD20 MAbs …
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The Relationship between methylation and genes associated with opioid response in humans.
… The promoter region methylation of ABCB1/MDR1, CYP2D6 and OPRM1 genes were analysed by pyrosequencing in smoking, opioid exposed and control pilot populations. Genetic variations within ABCB1/MDR1, COMT, CYP2B6, CYP2D6 and OPRM1 genes were also investigated. Tissue opioid concentrations …
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BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE
… cells that over-express the efflux transporter MDR1 were used to examine effects of OHCT on accumulation of the MDR1 substrate estrone-sulfate and to verify that MDR1 does not transport unconjugated AFB1. OHCT at a high concentration (120 µM) reduced cellular accumulation of estrone sulfate …
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Age-Associated Hepatic Drug Transporter Expression and Its Implications for Pediatric Pharmacotherapyflexibility affect DNA topoisomerase I function
… the multidrug resistance 1/P-glycoprotein (MDR1/P-gp) and the multidrug resistance protein 2 (MRP2), serve as major hepatic transporters that mediate the biliary excretion of various organic anions and cations along with glutathione-, glucuronate-, or sulfate-conjugates of several drug …
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Expression and function of drug transporters in primitive CML cells
… cells over-expressed ABCG2 mRNA. In contrast MDR1 expression was reduced in CML CD34+ cells and MRP1 was detected at similar expression levels in both populations. All three drug transporters were expressed at the protein levels in CML CD34+ cells. It was determined that at therapeutic …
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Modulation of drug transport by citrus fruit juices
… Bi-directional digoxin transport data across the MDR1-transfected L-MDR1 cells also produced a similar conclusion. The hypothesis could further be extended to the pOCT2-mediated transport in the LLC-PK1 cells. Data for the orange juice suggested that taxonomy, rather than dominant flavonoid …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… <p>Constitutive overexpression of the MDR1 gene, which encodes an efflux pump of the major facilitator superfamily, is another cause of resistance to fluconazole in clinical C. albicans strains. The regulator of MDR1 gene expression has not been identified or characterized. Using …
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Placental P-glycoprotein: Role in disposition of medications administered during pregnancy
… polymorphisms in the Multidrug Resistance 1 (MDR1) gene encoding P-gp associated with decreased protein expression yet increased transport activity in these patients. P-gp was found to transport medications used in the treatment of conditions during pregnancy: namely opiate dependence, …
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Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen
… Polymorphismen in den Membran-Transportproteinen MDR1, MRP1, MRP2, MRP3 und BCRP auf die Pharmakokinetik und ausgewählte Nebenwirkungen des Zytostatikums Doxorubicin zu untersuchen. Dazu wurden die Plasmakonzentrationen von Doxorubicin und Doxorubicinol von 94 Krebspatienten durch HPLC analysiert. …
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Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
… of genes including cytochrome P450 (CYP) and Mdr1 which play critical roles in chemicals metabolism and transportation. Induction of CYPs contributes to adverse drug-drug interactions. Non-toxic, PXR-specific antagonists will be valuable in attenuating the adverse drug-drug interaction which …
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ERG11-Mediated Azole Resistance in Candida albicans
… genes <em>CDR1</em>, <em>CDR2</em>, and <em>MDR1</em> is a common mechanism of drug resistance in <em>C. albicans</em> and the majority of previous investigations pertained to defining mechanisms of transcriptional regulation of efflux transporters. Alternatively to efflux transport, point …
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Expression Pattern of Drug-Resistance Genes in Matched Clinical Isolates of Candida albicans at Variable Fluconazole Exposure Times
… the Major Facilitator Transporter encoding gene MDR1, or c) ERG11, the azole target gene. Previous studies have shown gene expression in a matched set of clinical isolates is maximized at the drug concentration that matches the minimum inhibitory concentration (MIC80) of the strain to FLC. This …
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The Role of the SCD1 Protein in Targeting PIN2 Protein in Arabidopsis Thaliana
… of auxin transport proteins PIN1, PIN2, PIN3, MDR1, and AUX1 fused to fluorescent proteins. The PIN protein reporters were expressed in fewer cells at lower intensity in <italic>scd1-1<italic> at 25° C. PIN1 and PIN2 exhibited altered localization and accumulation in endomembrane bodies. …
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