Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"MDR-TB"”.
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Ototoxicity Monitoring using Automated Extended High-Frequency Audiometry and the Sensitive Range of Ototoxicity in Patients with MDR-TB
… emergence of multi-drug resistant tuberculosis (MDR-TB). Some of the medications used to treat MDR-TB are damaging to the cochlea and auditory nerve (ototoxic) and can lead to permanent hearing loss and/or balance disorders. Ototoxicity monitoring aims to reduce this burden by preventing or …
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Prevalence of multi-drug resistance tuberculosis MDR-TB and associated risk factors among patients in Vhembe Region of Limpopo. South Africa
… prevalence of drug-resistant tuberculosis (DR-TB) poses a critical and significant obstacle in the management of tuberculosis (TB) worldwide. This driven by the emergence of multidrug-resistant tuberculosis (MDR-TB) strains and co-infection of TB with human immunodeficiency virus (HIV) have …
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Prevalence of Multidrug-Resistant Tuberculosis in Adults at University Teaching Hospital
Tuberculosis (TB) is an infectious disease caused by There were 14.4 million individuals worldwide living with TB including half a million cases of Multidrug-resistant (MDR) TB in 2006. A most serious aspect of the problem has been the emergence of MDR-TB and extensively drug-resistant (XDR) …
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Prevalence of Multidrug-Resistant Tuberculosis in Adults at University Teaching Hospital
Tuberculosis (TB) is an infectious disease caused by There were 14.4 million individuals worldwide living with TB including half a million cases of Multidrug-resistant (MDR) TB in 2006. A most serious aspect of the problem has been the emergence of MDR-TB and extensively drug-resistant (XDR) …
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Acceptability of Oral Immunization Against Cholera and Typhod Fever among School Children in Lusaka
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. There were 14.4 million individuals worldwide living with TB including half a million cases of Multidrug-resistant (MDR) TB in 2006. A most serious aspect of the problem has been the emergence of MDR-TB and extensively …
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Acceptability of Oral Immunization Against Cholera and Typhod Fever among School Children in Lusaka
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. There were 14.4 million individuals worldwide living with TB including half a million cases of Multidrug-resistant (MDR) TB in 2006. A most serious aspect of the problem has been the emergence of MDR-TB and extensively …
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A pharmacometric approach to optimal use of second line drugs for multidrug-resistant tuberculosis
… treatment regimens for multidrug resistant TB (MDR-TB) were long and toxic. Consequently, only approximately half of MDRTB patients completed their treatment. TB dosing guidelines have historically been unrefined with little consideration for pharmacokinetic/pharmacodynamic relationships. …
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Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
… T1291C, A827G and 961 indel C) in a cohort of MDR-TB patients; To determine whether HIV positive MDR-TB patients are more likely to develop aminoglycoside-induced hearing loss than HIV negative MDR-TB patients; To provide clinical guidelines to the medical fraternity on the use of …
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Environmental health recommendations for Multidrug-Resistant Tuberculosis in low- and middle-income countries: a systematic review
… the management and prevention of Tuberculosis (TB) having shown some success, Multidrug-Resistant Tuberculosis (MDR-TB) may potentially compromise these endeavours. MDR-TB has the potential to become the most dominant form of TB in low- and middle-income countries (LMICs). The impact of …
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Improved treatment outcomes with bedaquiline when substituted for second-line injectable agents in multidrug-resistant tuberculosis: A retrospective cohort study
… treatment of multidrug-resistant tuberculosis (MDR-TB), but the efficacy and safety of this strategy is unknown. Methods We performed a retrospective cohort study to evaluate treatment outcomes for MDR-TB patients who substituted bedaquiline for SLIs. Adults receiving bedaquiline substitution …
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Factors that influence the utilisation of ototoxicity monitoring services for patients on treatment for drug-resistant tuberculosis
… Treatment of multi-drug resistance tuberculosis (MDR-TB) includes aminoglycoside antibiotics which are known to cause hearing loss. Ototoxicity monitoring services are often provided to patients undergoing treatment for MDR-TB for early detection of ototoxic hearing loss to facilitate alerting the …
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Costing analysis of levofloxacin as antibiotic prophylaxis for pediatric household contacts of multi-drug resistant tuberculosis patients in a South African setting
Background The incidence of TB in children under 15 years, accounts for 8% of the global TB burden. In 2018, the World Health Organisation (WHO) estimated that there were approximately 11 000 multi-drug resistant (MDR) TB cases in South Africa. Despite having very clear guidelines on TB treatment …
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The impact of undernutrition on tuberculosis prevalence and treatment outcomes in Ethiopia
Introduction: Tuberculosis (TB) is a leading infectious cause of death globally, with an estimated 10.6 million new cases and 1.3 million deaths annually. The emergence of multidrug-resistant tuberculosis (MDR-TB), characterized by resistance to isoniazid and rifampicin, further complicates the …
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The impact of undernutrition on tuberculosis prevalence and treatment outcomes in Ethiopia
Introduction: Tuberculosis (TB) is a leading infectious cause of death globally, with an estimated 10.6 million new cases and 1.3 million deaths annually. The emergence of multidrug-resistant tuberculosis (MDR-TB), characterized by resistance to isoniazid and rifampicin, further complicates the …
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Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV
… of rifampicin- and/or multidrug-resistant (RR/MDR) -TB, i.e. Mycobacterium tuberculosis resistant to rifampicin and/or isoniazid is increasing, especially in settings with high HIV prevalence. Optimising the prevention and treatment of RR/MDR-TB in children in such settings is critically …
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Distortion product otoacoustic emissions: towards reliable and valid early identification and monitoring of hearing in adults receiving ototoxic medication
Background: Multidrug-resistant tuberculosis (MDR-TB) patients receive aminoglycosides as part of their treatment. These drugs are ototoxic, and can cause permanent damage to the cochlea, resulting in a debilitating hearing loss, which has a negative impact on an individual's quality of life. Early …
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The Epidemiology and Evolution of Rifampicin Mono Resistant Tuberculosis in Khayelitsha, Cape Town, South Africa
… to the World Health Organization Global TB report 2018, rifampicin monoresistant tuberculosis (RMR-TB) comprises 22% and 38% of all rifampicin-resistant TB (RR-TB) globally, and within South Africa, respectively. National surveys from South Africa show an increasing proportion of RMR-TB …
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An evaluation of the palliative care-related outcomes of a cohort of TB patients in a district hospital setting: a multiple methods quality improvement study
Although curable, tuberculosis (TB) remains a serious health care problem. During 2011 there were almost 9 million new cases and 1.4 million TB deaths worldwide. The World Health Organisation (WHO) lists South Africa as a country with a high TB, HIV and MDR-TB burden. In this country the dual …
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Three-Dimensional (3D) pharmacophore-based identification of possible ATP-synthase inhibitors for mycobacterium tuberculosis (Mtb)
Tuberculosis (TB) is defined as a chronic infectious disease caused by the air-borne transmission of Mycobacterium tuberculosis (Mtb). Due to high prevalence of Mtb in South Africa, it is classified as a high burden country by the World Health Organization (WHO). Multi-drug resistant TB (MDR-TB) …
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