Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"MDMX"”.
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Context Dependent Roles of MDMX (MDM4) and MDM2 in Breast Cancer Proliferation and Circulating Tumor Cells
… the E3 ubiquitin ligase MDM2 and its homolog MDMX. Expression of MDM2 and MDMX occurs in both estrogen receptor α positive (ER+) and triple negative breast cancer (TNBC). We and others have reported that estrogen activated MDM2 strongly promotes proliferation in ER+ T47D breast cancer cells in …
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ScRING finger protein, Mdm2, MdmX, p53, cancer, ubiquitination, drug discovery, ZINC16046951, University of Zululand, South Africa
… for RING finger-type E3 namely, Mmd2 and MdmX. Expression, purification, Far-UV CD, Intrinsic tryptophan fluorescence, SE-HPL chromatography and ANS fluorescence were used to biochemically and structurally characterise ScRING finger protein. In silico inhibitory studies, for Mdm2 and MdmX …
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Targeting mutant p53 in cSCCs
… cell lines.<br/><br/>6. A potential isoform of MDMX (51 kDa) is strongly upregulated in all cSCC cell lines examined. There is an association between the ability of MDMX siRNAs to deplete the 51 kDa protein and reduce mutant p53 protein levels and stability. Furthermore we show that the protein …
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Re-thinking the role of ribosomal proteins in the Mdm2-p53 axis
… Additionally, they downregulate levels of MdmX, a homolog of Mdm2 that also suppresses p53 activity. In the second study, a novel extra-ribosomal function has been identified for RPL36A. Unlike other ribosomal proteins that interact with and activate the Mdm2-p53 axis, RPL36A represses it. …