Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"MDMA"”.
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Glutamate and MDMA Neurobehavioral Toxicity
±-3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a ring-substituted amphetamine derivative, and a popular psychoactive drug of abuse. This drug evokes a well-documented acute increase in the release of serotonin, dopamine, and acetylcholine, as well as persistent reductions in markers of …
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NEUROPHYSIOLOGICAL CORRELATES OF ECSTASY/MDMA USE ON EXECUTIVE FUNCTIONING
The purpose of this thesis was to assess the integrity of the serotonin system, by measuring the neurophysiological response to tasks that measure executive functions, and neuroendocrine function in ecstasy users and non-users. Each of the proposed executive functions outlined in Miyake et al.’s …
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The Synthesis and Chemical Profiling of 3,4-Methylene-Dioxymethamphetamine (MDMA) and Analogues
… profiles of 3,4-methylenedioxymethamphetamine (MDMA) and its analogue methylone that were synthesised from uncontrolled ‘pre-precursors’. Methylone was synthesised from catechol by one synthetic route. Safrole was synthesised from catechol by two synthetic routes (Routes 1 and 2) and from …
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The differential effects of MDMA (ecstasy) use on executive and memory processes
The purpose of this thesis was to examine the nature of executive function deficits in ecstasy users, and the contribution of these executive functions to performance on other cognitive tasks. Using recent theoretical models of executive functioning recreational ecstasy-polydrug users were tested …
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STUDIES ON THE ACUTE AND LONG-TERM EFFECTS OF MDMA (3,4- METHYLENEDIOXYMETHAMPHETAMINE)
3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) is a popular recreational drug. Administration of MDMA to rats produces an acute, rapid release of cerebral 5-HT and dopamine and depletion of 5-HT. After an initial recovery, 5-HT concentrations then decline for 3-12 months due to neurotoxic loss …
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Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain
MDMA (Ecstasy), a methylamphetamine derivative, has been found to produce severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance …
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Thermoregulatory, behavioural and neurochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related stimulant drugs.
3,4-Methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is an amphetamine derivative widely used in rave party and club scenes. In some users, MDMA causes fatalities, most often due to acute hyperthermia which leads eventually to multi-organ failure. Other structurally related drugs, including …
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Users' explanations of their psychoactive substance use, with a particular focus on MDMA (Ecstasy)
… substance users' explanations of their MDMA usage with the aim of investigating how users explain their own substance abuse, and secondly to ascertain if and/or how their accounts diverge or converge with currently used models. Thirdly, it is intended to explore the extent to which …
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The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
3,4-(±)-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a widely abused amphetamine derivative with potent stimulant properties. The neuropharmacological effects of MDMA are biphasic in nature. MDMA initially causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia …
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The acute and long lasting psychological effects of 3, 4-methylenedioxymethampethamine (MDMA, 'ecstasy'): a cohort study conducted during the period 2002-2007
Rationale - MDMA is currently an illegally abused recreational drug. Non-human animal studies demonstrate that MDMA causes non-repairable damage to serotonergic neurons. As the acute behavioural effects of MDMA are similar between non-human animals and humans, it is plausible to suggest that the …
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Impact of genetic variability in the serotonin transporter, Tryptophan Hydroxylase-2, and Serotonin 2A Receptors on MDMA Use and Impulsivity
Ecstasy [MDMA; (±)-3,4-methylenedioxymethamphetamine] is popular for positive effects including enhanced mood and empathy, despite potential deleterious physical and psychological consequences. The serotonin (5-HT) system plays a prominent role in the neurochemical and behavioral effects of MDMA, …
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Serotonin 5-HT<sub/>2C</sub> receptors: Role in (+)-MDMA sensitization and distribution in the ventral tegmental area
… (+)-3,4-methylenedioxy-methamphetamine [(+)-MDMA; \"ecstasy\"] administration stimulates 5-HT<sub/>2C</sub> receptors (5-HT<sub/>2C</sub>R) to exert inhibitory influence on (+)-MDMA-induced behaviors. Thus, changes in 5-HT<sub/>2C</sub>R responsiveness upon repeated intermittent exposure to …
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Estradiol and MDMA affect the susceptibility and immune response to genital herpes and genital herpes immunization
… Meanwhile, 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) was abused by over 1.2 million Americans in 2007 and is popular in the dance club, rave and circuit party scenes. MDMA and other similar drugs are reportedly associated with increased incidence of sexually transmitted infections, …
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Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners
… of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) induces “behavioral sensitization,” an enhancement of its behavioral effects. The molecular changes underlying behavioral sensitization may be linked to neuropsychological sequelae (e.g., depression, anxiety) seen upon withdrawal …
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Vulnerability to cognitive, neurotoxic and neuroinflammatory effects of toxins that induce Parkinson's disease after administration of amphetamine-related drugs in mice
… users. 3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine-related drug which may have neuroinflammatory and neurotoxic effects. The present study was aimed at evaluating in mice whether administration of MDMA during adolescence might influence neurotoxicity towards dopaminergic …
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Individual sensitivity to novelty and (+)-3,4-methylenedioxymethamphetamine: Roles for serotonin and GABA neurotransmission
… effects of 3,4-methylenedioxymethamphetamine (MDMA) and these differences are rooted, in part, in individual sensitivity to the drug effects, we utilized two animal models of increased sensitivity in the current studies. First, in a sensitization animal model we examined the mechanisms of …
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