Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"MDA-MB-468 cells"”.
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Phytochemicals from Graviola fruit selectively inhibit breast cancer cells growth involving EGFR signaling pathway
… (GFE) on specific human breast cancer (BC) cells. GFE was found in our preliminary screening to selectively inhibit the growth of certain human BC cells (MDA-MB-468) but did not affect non-transformed breast epithelial MCF-10A cells. GFE treatment was very effective against the growth of …
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Study of the Gain-of-Function Mutant p53 and PARP1 in Triple-Negative Breast Cancer
<p>Cancer cells often lose expression of the p53 protein or express mutant forms of p53. Some of these mutant p53 proteins, called gain-of-function mutant p53, have gained oncogenic functions. Previously, our group observed mutant p53 R273H interacts with replicating DNA and upregulates the …
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Anti-cancerous and anti-metastatic effects of Corchorus Olitorius on breast cancer cell lines
… on selected breast cancer cell lines: MCF-7, MDA-MB-231 and MDA-MB-468. Acetone, hexane and methanol were used to extract bioactive compounds from C. olitorius leaves based on their solubility. These extracts were subsequently tested to evaluate their potential anti-proliferative, …
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BIOACTIVATION OF NATURAL DIETARY PRODRUGS BY SPECIFIC CYTOCHROME P450 ENZYMES
… prodrugs with latent activity. Thus, the combination of tumour specific CYPs as ‘rescue enzymes’ with a suitable substrate provides a platform to develop selective anticancer prodrugs. This thesis describes the bioactivation of natural prodrugs by tumour specific CYPl enzymes. An initial …
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Trim24 Orchestrates Metabolic Reprogramming and Emt In Breast Cancer
… of immortalized human mammary epithelial cells (TRIM24-iHMECs) and efficient growth of intermediate to high-grade xenograft tumors.</p> <p>TRIM24 induces gross metabolic changes in the iHMECs with increased glycolysis and TCA cycle along with glucose uptake. TRIM24 causes deregulation of …