Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"MDA-MB-435"”.
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Anticancer activity of peach and plum extracts against human breast cancer in vitro and in vivo
… the proliferation of the estrogen-independent MDA-MB-435 breast cancer cells over the estrogen-dependent MCF-7 or the normal MCF-10A breast cells. Similarly, BS extracts, though less effective than RL extracts, showed greater effects on MDA-MB-435 cells compared to the other cell lines. …
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Characterization of perillyl alcohol as a cell migration-inhibiting compound
… properties in MCF-10A normal and MDA-MB 435 cancerous breast cells. Perillyl alcohol at 0.5 mM inhibited normal breast cell migration while it failed to affect cancer cell migration. Finally, we examined the loss of prenylation of RhoA, a small GTPase protein involved in the …
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Drug Discovery in Redox Biology: From Natural Products to Structural Biology
… also showed activity against MDA-MB-435 cells. These phenolic scaffolds represent potential redox-active anticancer leads. To complement natural product discovery with structural insight, thioredoxin glutathione reductase (SmTGR), a key enzyme in parasite redox homeostasis, was …
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Einfluss von GnRH Analoga auf die Metastasierung humaner Mammakarzinomzellen in vitro und in vivo
… werden, dass während der Kokultur von MCF-7 oder MDA-MB-231 Zellen mit Osteoblasten-ähnlichen Zellen eine Regulation bestimmter Metastasierungs-assoziierter Gene stattfindet. GnRH Analoga besitzen jedoch keinen Einfluss auf die veränderte Expression dieser Gene. Ein sehr deutlicher Effekt wurde im …
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The Role of the Methyl DNA Binding Domain Protein 2 (MBD2) in Breast Cancer
… in the role of Methyl-Binding Domain Proteins (MBDs) in cancer, where repatterning of CpG methylation is common. In this dissertation I summarize and discuss observations made in the Ginder Lab linking MCBPs to the progression of neoplastic disease. It is clear from our work that the Methyl …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
Synergistic interaction between pairs of membrane-bound receptors has been linked to signalling, cell communication and tumour progression. This study has shown that cluster of differentiation (CD) 74 and CD44 act in synergy and are susceptible to the effect of the macrophage migration inhibitory …
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Antitumor activity of antimalarials in human breast cancer cells
… demonstrate that MCF-7, MCF-7ras, T47D, MDA-MB-231, and MDA-MB-435 cells transiently differentiate before undergoing apoptosis in response to quinidine. The cells accumulated lipid droplets and the cytokeratin 18 cytoskeleton was reorganized. Hyperacetylated histone H4 appeared within 2 h …
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Development of monoclonal antibodies for the identification of novel invasion associated targets in human cancer.
… MiaPaCa-2 clone 3 pancreatic cell line, and the MDA-MB-435-SF breast cancer cell line. Two MAbs were identified that could successfully block cancer invasion in vitro. MAb 7B7 G5 (2) significantly reduced invasion in the MiaPaCa-2 clone 3 pancreatic cell line; the SKBR-3 and MDA-MB-231 breast …
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Overcoming Acquired Resistance to BRAF Inhibitors by Novel Synergistic Drug Combination and Discovery of Novel Smac Mimetics as Selective Survivin Inhibitors
… 1 and 2) of this dissertation presents a novel combination study of melanoma therapy. Acquired clinical resistance to vemurafenib, a selective BRAFV600E inhibitor, arises frequently after short term chemotherapy. Since the inhibitions of targets in the RAFMEK-ERK pathway result in G0/G1 cell cycle …
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Metabolic Exogenous Contrast Agents for use in Breast Cancer Detection and Therapy Monitoring
… respond. Known ER+ cells, MCF7, and ER- cells, MDA-MB-435, were treated with tam. 2-NBDG was used to determine therapeutic responders from non-responders by measureable differences in fluorescence uptake. </p><p>Finally, the effect of hypoxia, low oxygenation, on 2-NBDG uptake is discussed. The …
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Charakterisierung der Funktion des Tight Junction Proteins hu-CLDN1 und seine Bedeutung bei der Tumorgenese
… konnten bis heute dieser 4 Transmembrandomänen Proteinfamilie 18 Mitglieder mit unterschiedlichen Gewebeverteilungen zugeordnet werden. Parallel zum murinen Claudin-1 wurde von (Swisshelm et al. 1999) das humane Claudin-1 mit einer 91 prozentigen Sequenzhomologie zum murinen Protein …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… survivin, MDM2, and tubulin. Survivin, a member of the inhibitor of apoptosis proteins (IAPs) family, serves as both an apoptosis suppressor and a pivotal player in cell division. Its significance as a cancer drug target arises from its heightened expression in various human cancers, …
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Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2
… pro- und antiangiogenen Faktoren abhängig. Thrombospondin-2 (TSP-2) gehört zu den endogenen antiangiogenen Faktoren. TSP-2 hemmt das Tumorwachstum durch Hemmung der Gefäßneubildung, die für die Progression von Tumoren notwendig ist. Im Gegensatz zu dem strukturell verwandten Thrombospondin-1, …