Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"MDA-MB-231 cells"”.
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Identification of Cell Biomechanical Signatures Using Three Dimensional Isotropic Microstructures
… to investigate whether the normal and cancerous cells differentially respond to their underlying substrate and whether the differential response of the cells leads to a novel label-free technique to distinguish between normal and cancerous cells. Three different generations of 3-D isotropic …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… and oestrogen receptor-positive breast cancer cells. However, AJ-5 is poorly soluble, therefore, a series of water soluble AJ-5-based compounds were synthesized. The aim of this study was to test and characterise the anti-cancer activity of one of these AJ-5 analogues, BTC2, in triple negative …
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Studien zur Regulation der Clusterin-Expression in der MCF-7- und MDA-MB-231-Mamma-Karzinom-Zelllinie
… is produced in inflamed epithelia and apoptotic cells and inhibits apoptotic cell death. In human breast carcinomas, sCLU overexpression is associated with tumor progression. To date, little is known about the hormonal regulation of clusterin expression in human breast cancer. Consequently, the …
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Investigating pathways in tumour cell migration and invasion in response to novel isoquinolinone compounds
Abstract The ability of cancer cells to disseminate from a primary tumour and invade via the breaching of surrounding tissue vasculature is a hallmark of the metastatic phenotype. Cancer cells are highly dynamic adopting a wide range of mechanisms in order to accomplish this enhanced migrational …
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Effect of uptake pathway on non-viral gene delivery in vitro and in vivo
… (PAMAM)-mediated gene delivery in HeLa cells through the use of small molecule drugs and small-interfering RNA [1-2]. The goal of this thesis is to further elucidate the effects of cellular uptake mechanism on non-viral gene delivery in vitro and in vivo utilizing a small hairpin RNA …
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The regulation of LIV-1 mRNA in MDA-MB-231 human breast cancer cells and its association with E-cadherin (CDH1)
… the estrogen-regulated gene encoding a member of the<sup> </sup>ZIP family of zinc transporters (SLC39A6), has been implicated in both growth and metastasis of<sup> </sup>estrogen-receptor (ER) positive (+) and negative (-) breast cancer cells<em>.<strong> </strong></em>In ER<sup>+</sup> …
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A Signal to Divide: Apoptotic Extracellular Vesicles as Carriers of Mitogenic and Immunogenic Signals
<p>Efficient replacement of dead cells in epithelial tissue is crucial for maintaining barrier function and tissue homeostasis. Apoptotic cells can signal to neighboring cells to stimulate proliferation and compensate for cell loss and maintain overall cell numbers in normal physiology and cancer. …
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Characterisation of Pharmacological Mechanisms and Potential Therapeutic uses of FK866
… Nampt inhibition, NAD+ levels were measured in cells treated with FK866 and inhibition of each of the main NAD+ consuming enzymes (PARP, sirtuins or CD38). This revealed differential NAD+ consumption rates by the different NAD+ consuming enzymes in MDA-MB-231 cells, with sirtuins being the major …
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Anti-breast cancer activity of Coptidis Rhizoma-Euodiae Fructus formulae
… anti-cancer activity. Dual herbal formulae combined with Coptis and Euodia with different ratio have been clinically used to treat multiple digestive system disorders. The aims of this research are to evaluate the anti-breast cancer potential of Coptis-Euodia formulae, and standard alkaloids …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… receptor positive MCF-7 and T47D breast cancer cells. Extracts of both male and female branches and leaves (500 µg/mL) reduced cancer cell viability by 75–80%. These effects were mediated by intracellular calcium overload via TRPV1 activation, leading to apoptosis. Blocking TRPV1 with …
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Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
… kinase (AMPK) activation in breast cancer cells in response to interstitial fluid flow. Additionally, we explored the involvement of AMPK in breast cancer cell migration. An in-vitro three-dimensional (3D) cell culture model utilizing collagen-Matrigel matrices was used. Interstitial fluid …
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In Vivo Kinome Screen Reveals Non-Canonical Cdk-Driven Metabolic Adaptation In Brain Metastasis
… model using the human breast cancer cell line MDA-MB-231. Several of the kinase pools led to decreased brain metastasis-specific survival in nude mice, shortening survival time by up to 50% relative to controls. Targeted next-generation sequencing (NGS) was performed to analyze pre- and …
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Effect of cmvIL-10 on Exosome Production by Human Breast Cancer Cells
… Exosomes are 30-100nm vesicles produced by most cells which carry protein and RNA to cells in their microenvironment. The aim of this study is to investigate the impact of HCMV-infection of a secreted viral cytokine, cmvIL-10, on exosome production by highly metastatic breast cancer cells.</p> …
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Notch-1 Activates Nf-Кb Activity in Cervical Cancer and Estrogen Receptor Negative Breast Cancer
… cancer and inhibiting Notch-1 sensitizes cancer cells to apoptosis. However, the mechanism by which Notch-1 promotes cell survival is not known. NF-КB is also deregulated in these two cancers and might be the downstream signaling effector of Notch-1 to modulate cell survival and apoptosis. Here, …
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Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
… leads to AMPK activation in human breast cancer cells. We report that a variety of proteasome inhibitors activate AMPK in all of the tested cancer cell lines. Our data using Liver Kinase B1 (LKB1)-deficient cancer cells suggests that proteasome inhibitor-induced AMPK activation is primarily …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… matrix proteins, but also can process a number of bioactive molecules, and to perform key functions in tumor progression, and in other diseases. In this study, we report that TIS21 can decrease the expression at both mRNA and protein levels of MMPs in human breast cancer (MDA-MB-231) cells …
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The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration.
… ERK1/2 phosphorylation after stimulation of cells with the ligand, KP-10. The effects of KP-10 stimulation on the growth rate and migration speed of the cell lines were assessed using crystal violet staining and scratch assay, respectively. Lastly, the last exon, exon 5 of the KISS1R gene in …
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Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positive and Hydrophobic Residues as Molecular Transporters
<p>The cell membrane properties create a significant obstacle in intracellular delivery of cell-impermeable and negatively charged molecules. Amphiphilic cyclic peptides containing alternative arginine and tryptophan such as [WR]<sub>5</sub> have been shown to enhance the transport of cargo …
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Characterization of novel small molecule inhibitors of FOXM1 as potential therapeutic agents for breast cancer
… transcription networks in breast cancer cells. In addition, gene networks related to the known role of FOXM1 as a master regulator of the cell cycle, including G1/S and G2/M transition, execution of S-phase and mitotic processes, DNA damage repair, and apoptosis were impacted. Consistent …
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Role of protein kinase C isoforms in human breast tumor cell survival
… PKC delta and PKC zeta isoforms from MCF-7 and MDA-MB-231 human breast tumor cells by antisense oligonucleotides significantly impaired survival following radiation insult. Antisense oligonucleotides were shown to be effective and selective inhibitors of specific PKC isoforms. The PKC delta …
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