Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"MDA-MB-231 cell line"”.
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The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines.
… burden in the UK and around 8% of the total number of cancer related deaths. Protein kinase C (PKC) isoforms have been shown to be strongly modulated in many androgen sensitive tumour cell lines. Increased expression of some PKC isoforms has also been linked to immortality in many cancer cell …
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Biomechanical regulation of cancer metastasis
… cancer through the body. To metastasize, cancer cells must leave the primary tumor, access the circulatory system, adhere to the endothelium of the metastatic site, and migrate out into the surrounding tissue. A major limitation in the discovery and development of drugs that prevent the spread of …
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The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration.
… the role of endogenous KISS1R in breast cancer cell proliferation, invasion and migration. Firstly, endogenous protein expression of the receptor was determined in 3 breast cancer cell lines by western blotting. Secondly, the signalling potential of the receptor was determined by assessing …
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Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer
… in TNBC compared to HER-2 positive breast cancer cell lines. EGF treatment stimulated phospho-EGFR which was inhibited by gefitinib. Sensitivity to gefitinib was associated with decreases in PMAPK and P-Akt, and G1 cell cycle arrest. Combined treatment with gefitinib and chemotherapy was more …
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The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque.
… were synthesized. This was achieved via a combination of both solid and solution phase peptide synthesis. The first phase of the research study focused on the synthesis of a targeted MRI contrast agent designed to image legumain expressing atherosclerotic plaques. This was achieved by using a …
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The proteomic analysis of resistance to anticancer therapy in human breast cancer
… to anticancer therapy in human breast cancer cells. This technique was applied to compare the MCF7 cell line with novel derivatives displaying significant resistance to cisplatin (MCF7CR) and radiotherapy (MCF740Gy). Differentially expressed proteins were identified by MALDI-TOF MS analysis. …
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An Activity-Based Proteomics Approach for Identifying Ajoene's S-thiolation Protein Targets in Blood and Cancer Cells
… aspects of ajoene's cytotoxicity towards cancer cells in terms of S-thioallylation via disulfide exchange are then discussed at length. Of crucial importance for the chemical biology studies to follow was the conclusion that S-thioallylation by ajoene is regioselective at the vinyl sulfur, as …
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Design, synthesis and biological evaluation of bioorganometallic metallarectangles
… Additionally, the evolution of resistant cancer cell sub-types has rendered many of these highly efficacious platinum drugs, ineffective. Utilizing alternative platinum group metals (PGMs), such as iridium and ruthenium, and incorporating known pharmacophoric scaffolds within the framework of a …
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Pharmacogenetic analysis of admc polymorphisms affecting the efficacy of TB treatment in tuberculosis patients from Tanzania and Uganda, and pharmalogical evaluation of potent medicinal plant extracts used in the treatment of tuberculosis
… was evaluated on C3A and Vero monkey kidney cell lines and the anti-inflammatory activity of the compounds against RAW 264.7 macrophages. Finally, the anticancer activity of the plant extracts was evaluated against triple-negative breast cancer MDA-MB 231 cell line and determined the type of …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… survivin, MDM2, and tubulin. Survivin, a member of the inhibitor of apoptosis proteins (IAPs) family, serves as both an apoptosis suppressor and a pivotal player in cell division. Its significance as a cancer drug target arises from its heightened expression in various human cancers, …
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Exploring the in vitro effects of chronic methamphetamine exposure on selected cancer cell lines
… well documented in multiple organ systems, the cellular consequences of chronic METH exposure in cancer biology remain poorly defined. Understanding how tumour cells respond to sustained psychostimulant-induced stress may provide insight into metabolic and redox adaptations relevant to cancer …