Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 208 for “"MDA-MB-231"”.
-
Identification of Cell Biomechanical Signatures Using Three Dimensional Isotropic Microstructures
… MCF10A normal human breast epithelial cells and MDA-MB-231 metastatic human breast cancer cells. Primary findings on the first generation of silicon substrates demonstrated a distinct adhesion and growth behavior in HS68 and MDA-MB-231 cells. MDA-MB-231 cells deformed while the fibroblasts …
-
Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies.
… two human metastatic breast cancer cell lines, MDA-MB-231 and SKBR-3. A series of novel BNIPs, bisnaphthalimidopropyl-piperidylpropane (BNIPPiProp), bisnaphthalimidopropyl- ethylenedipiperidine (BNIPPiEth) and (trans(trans))-4,4-methylenebis-cyclohexylamine (trans,trans-BNIPDaCHM) were …
-
URSOLIC ACID INHIBITED PROLIFERATION AND INVASION OF MDA-MB-231 HUMAN BREAST CANCER CELLS VIA REGULATING CELLULAR SIGNAL TRANSDUCTION PATHWAYS
… that UA inhibits proliferation and invasion of MDA-MB-231 human breast cancer cells via regulating cellular signal transduction pathways. Specific objectives are designed as: a) to investigate anti-proliferation and anti-invasion effects of UA in MDA-MB-231 human breast cancer cells; b) To …
-
The role of the kisspeptin receptor, KISS1R, in breast cancer cell proliferation, invasion and migration.
… exon, exon 5 of the KISS1R gene in the BT-20 and MDA-MB-231 cell lines was assessed by Sanger sequencing. The results show that KISS1R protein is expressed in all the breast cancer cell lines tested albeit at significantly different levels. The non-metastatic BT-20 cell line express a much higher …
-
Proteomic Investigation of Endocrine Therapy Resistance in Breast Cancer Investigating the Molecular Mechanisms for SERM Resistant Cell Lines Using SILAC-Based Proteomic Approach
… (IC50) was determined for MCF7, T47D, MDA-MB-231, MDA-MB-468, MDA-MB-453, BT-20 and MCF-10A breast cell lines using four endocrine-based therapeutic agents (Tamoxifen, 4-Hydroxytamoxifen OHT, Raloxifene, Anastrozole) to select viable strains for resistance studies. MCF7 (luminal-type A) …
-
Investigating pathways in tumour cell migration and invasion in response to novel isoquinolinone compounds
… similar A5 and A3 compounds reduce adhesion of MDA-MB-231 cells to Fibronectin, Matrigel, and Type I collagen which was paralleled in A5 treated HT1080 cells on these matrix components. Compound A5 also induced 2D migration of MDA-MB-231 cells on all matrix substrates. Cell movement of …
-
The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… these AJ-5 analogues, BTC2, in triple negative (MDA-MB-231) and oestrogen receptor-positive (MCF7) breast cancer cell lines. Cytotoxicity assays were performed and BTC2 was shown to inhibit the proliferative rates of breast cancer cells with calculated IC50 values of 0.49μM in MCF7 cells and …
-
Effect of uptake pathway on non-viral gene delivery in vitro and in vivo
… PEI and PEI-derivative gene delivery in HeLa and MDA-MB-231 cell cultures and xenograft tumors. First, we attached transferrin and folate ligands to PEI to direct internalization by clathrin- and caveolin-mediated mechanisms, respectively, and transfected HeLa and MDA-MB-231 cells with targeted …
-
Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer
… in PMAPK and P-Akt, and G1 cell cycle arrest. Combined treatment with gefitinib and chemotherapy was more effective than either gefitinib or chemotherapy alone. EGFR and P-EGFR expression were examined by immunohistochemistry in 101 breast tumours. Only 6 % were positive for EGFR and 3 % for …
-
Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
… to the 3D cell-matrix construct inside a flow chamber. The sub-cellular signaling activity of Src, FAK, and AMPK was visualized in real-time using fluorescent resonance energy transfer (FRET). We observed that breast cancer cells (MDA-MB-231) are more sensitive to interstitial fluid flow than …
-
Anti-breast cancer activity of Coptidis Rhizoma-Euodiae Fructus formulae
… anti-cancer activity. Dual herbal formulae combined with Coptis and Euodia with different ratio have been clinically used to treat multiple digestive system disorders. The aims of this research are to evaluate the anti-breast cancer potential of Coptis-Euodia formulae, and standard alkaloids …
-
Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery
… nucleic acid therapeutics across various cell membranes has always been one of the major challenges. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) have been promising for siRNA delivery. Therefore, to enhance siRNA delivery and efficient silencing of …
-
CHARACTERIZING THE ROLE OF FREE FATTY ACID RECEPTORS (FFARs) IN BREAST CANCER CELLS
… and stimulating FFAR2 & 3 with Propionate in MDA-MB-231 significantly upregulates as well as downregulates the essential EMT markers, E Cadherin and Vimentin respectively, along with curtailed cell invasion. Our data on proliferative pathway implies, FFAR3 over-expression reduces the …
-
The regulation of LIV-1 mRNA in MDA-MB-231 human breast cancer cells and its association with E-cadherin (CDH1)
… the estrogen-regulated gene encoding a member of the<sup> </sup>ZIP family of zinc transporters (SLC39A6), has been implicated in both growth and metastasis of<sup> </sup>estrogen-receptor (ER) positive (+) and negative (-) breast cancer cells<em>.<strong> </strong></em>In ER<sup>+</sup> …
-
The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
… in TNBC. P-glycoprotein (P-gp) is a transmembrane glycoprotein responsible for active transport of substances across the cell membrane out of a cell. It functions as an efflux pump and is overexpressed in many cancer cells. The altered expression of both EGFR and P-gp parallels an aggressive …
-
Characterisation of Pharmacological Mechanisms and Potential Therapeutic uses of FK866
… rates by the different NAD+ consuming enzymes in MDA-MB-231 cells, with sirtuins being the major NAD+ consuming enzyme. The glycolytic effects of Nampt inhibition was measured using SEAHORSE assays; which measured the oxygen consumption and extracellular acidification rates as well as measuring …
-
Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positive and Hydrophobic Residues as Molecular Transporters
<p>The cell membrane properties create a significant obstacle in intracellular delivery of cell-impermeable and negatively charged molecules. Amphiphilic cyclic peptides containing alternative arginine and tryptophan such as [WR]<sub>5</sub> have been shown to enhance the transport of cargo …
-
Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… receptor-positive T47D and triple-negative MDA-MB-231 breast cancer cells. In MDA-MB-231 cells, apoptosis was induced through TRPV1-mediated calcium overload, similarly to M. pomifera extracts. However, in T47D cells, apoptosis was driven by a 10-fold increase in reactive oxygen species …
-
Biological and Clinical Significance of Circulating Tumor Cells in Breast Cancer
… lungs were collected from the breast cancer (BC) MDA MB 231 xenograft model and characterized in two independent experiments using a microarray platform. CTCs were distinguishable from solid lesions by a set of 474 significantly differentially expressed genes. Among genes up-regulated in CTCs, the …
-
Molecular Study of Gβγ Dependent Breast Cancer Cell Migration and Invasion
… and invasion of both metastatic breast cancer MDA-MB-231 and MDAMB-436 cells by 40-50%. Migration and invasion of those cells in response to NIH-3T3 CM were also blocked by M119K, an inhibitor of Gβ , with maximum inhibition exceeding 80% and IC50 values of 1-2 μM. Activation of Gi-protein …
Page 1 of 11