Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"MD Anderson"”.
-
Accuracy of The Brcapro Risk Assessment Model In Males Presenting to Md Anderson For Brca Testing
… RISK ASSESSMENT MODEL IN MALES PRESENTING TO MD ANDERSON FOR<em> BRCA</em> TESTING</p> <p>Publication No. _______</p> <p>Carolyn A. Garby, B.S.</p> <p>Supervisory Professor: Banu Arun, M.D.</p> <p>Hereditary Breast and Ovarian Cancer (HBOC) syndrome is due to mutations in <em>BRCA1</em> and …
-
Computer-Aided Detection of Pathologically Enlarged Lymph Nodes On Non-Contrast Ct In Cervical Cancer Patients For Low-Resource Settings
… from normal tissues. A cohort of fifty-eight MD Anderson cervical cancer patients with pathologically enlarged lymph nodes were used as a training-test set. Similarly, twenty MD Anderson cervical cancer patients were obtained as a validation set. They contained 154 and 35 pathologically …
-
Temozolomide and Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor
… whose tumor specimens have been reviewed at the MD Anderson Cancer Center from January 1993 to June 2007 by a MD Anderson pathologist and were treated at the institution with available electronic medical records. We identified 128 patients, 79 with primary localized disease and 49 with recurrent …
-
Cancer Incidence In First and Second Degree Relatives of Brca1 and Brca2 Mutation Carriers
… genetic counseling at The University of Texas MD Anderson Cancer Center. We identified 9032 first and second degree relatives from 784 pedigrees which demonstrated a clear indication of parental origin of mutation. Standardized incidence ratios (SIRs) were used to compare the observed incidence …
-
Identifying Pathogenic Variants In Hereditary Cancer Syndrome Genes Via Tumor Molecular Profiling
… molecular profiling at The University of Texas MD Anderson Cancer Center, then performed a retrospective chart review to determine the proportion of such patients that received germline testing and had germline PVs identified. We found that 3.78% (13/2,990; 95% CI 3.09-4.46%) of tumor-only …
-
Factors and Attributes Related to Training Transfer in Healthcare Professionals Participating in Quality Improvement Training
… training program held at the University of Texas MD Anderson Cancer Center (MDACC) between 2005 and 2014; and to develop insight into how these factors and attributes facilitate or impede QI training transfer. The Success Case Method (SCM) was used to identify trainees with high and low levels of …
-
Cancers Associated With Brca1 and Brca2 Mutations Other Than Breast and Ovarian
… <p>A retrospective chart review of MD Anderson Cancer Center patients identified 1081 individuals with a <em>BRCA</em> mutation. A detailed cancer history for each person was collected and compared to the general population incidence rates reported by the CDC using standardized …
-
Exploring Motivational Factors to Pursue Genetic Counseling and Testing In Adolescent and Young Adult Cancer Patients
… with 30 individuals from the AYA Program at MD Anderson Cancer Center who attended or were referred to a genetic counseling appointment. Data analysis showed that motivational factors for patients who attended and/or were referred but did not attend a genetic counseling appointment include …
-
Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… the clinical and molecular features using our MD Anderson Cancer Center cohort. To delineate the mechanisms of adaptive and acquired resistance, we have characterized our KRASG12C mCRC patient-derived xenograft models that were treated with KRASG12C targeted therapies and on study paired …
-
Investigating The Role of Cholesterol Metabolism and Synthesis In Metastasis and Radiation Response In Aggressive Subtypes of Breast Cancer
… the growth of breast cancer in vivo. Studies at MD Anderson have shown that IBC patients taking cholesterol lowering drugs, statins, have improved survival outcomes, and also statins can improve the response to radiation in vitro. Furthermore, statins have been shown to target the cells with stem …
-
Predictors of Contralateral Breast Cancer In Brca Negative Women
… cohort of women in an IRB approved database at MD Anderson Cancer Center. The final cohort contained 572 women who tested negative for a BRCA1 or BRCA2 mutation, had their primary invasive breast cancer diagnosed under the age of 50, and had a BRCAPro risk assessment number over 10%. Of the 572 …
-
Investigation of The Functional Impact of Anti-Pd-1 On Tumor-Infiltrating Lymphocytes (Til) and Mapping of Tumor Genomic Features Relevant For Response to Til Therapy
… thereby enhancing treatment outcome. At MD Anderson, we have a 43% response rate to therapy when treating metastatic melanoma patients with adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TIL), but it is unknown what makes the other 57% of patients not respond to therapy. …
-
Evaluating Cancer Rates, Cancer Types, and Variant Hotspots Between Different Races and Ethnicities in Individuals with Li-Fraumeni Syndrome
… with germline P/LP <em>TP53</em> variants at UT MD Anderson Cancer Center was completed looking at race, ethnicity, number of cancer diagnoses, cancer types, and location of the <em>TP53 </em>variant (exon and codon). Two hundred and fifty individuals were included in the analysis. Notable …
-
Mapping The Human Vasculature By In Vivo Phage Display
… vascular beds. At the University of Texas MD Anderson Cancer Center, we have had the opportunity to perform phage display screenings in cancer patients in order to select for cancer specific targets directly in humans. These targets serve to define biochemical diversity of endothelial cell …
-
Genetic Predictors of Clinical Outcomes In Non-Small Cell Lung Cancer Patients
… was performed using a discovery population from MD Anderson (411 patients) and a validation population from Mayo Clinic (311 patients). Three SNPs (<em>IL17RA</em>:rs879576, <em>BMP8A</em>:rs698141, and <em>STK</em>:rs290229) that were significantly associated with survival were validated …
-
The Microsatellite Instability High Endometrial Tumor Microenvironment and Identifying Predictive Biomarkers of Response to Pembrolizumab
… MSI-H endometrial cancer patients treated at MD Anderson Cancer Center were obtained. Tissue samples originating from patients who did not receive pembrolizumab treatment (“untreated cohort ”; n = 11) were analyzed via RNA sequencing (RNA-seq). Pre-treatment archival tumor samples (“treated …
-
Genetic and Clinical Determinants of Racial/Ethnic Differences In Multiple Myeloma Susceptibility and Outcomes Focusing On Hispanics
… of a multi-ethnic patient population seen at MD Anderson Cancer Center. We conducted case-control association analysis in 143 self-identified Hispanic, 211 non-Hispanic black, 262 non-Hispanic white MM cases, and 633 healthy controls. We also described MM clinical characteristics at diagnosis …
-
Evaluating the Feasibility of a Nurse-driven Follow-up Telephone Triage Intervention to Improve Post-treatment Outcomes in Head and Neck Cancer Patients Undergoing Chemotherapy and Radiation in the Ambulatory Setting
… neck medical and radiation oncology services at MD Anderson Cancer Center, Houston Texas. Results: Acceptable feasibility was defined as the completion of 70% of the nurse-driven calls. The actual completion of the calls was 92.19% [95% CI = 88.09, 94.95]. The best predictor of lower symptom …
-
Identification and Characterization of De Novo Germline Tp53 Mutation Carriers In Families With Li-Fraumeni Syndrome
… de novo LFS patients difficult to study. Famdenovo.TP53 is a Mendelian Risk prediction model used to predict DNM status of TP53 mutation carriers based on the cancer-family history and several input genetic parameters, including disease-gene penetrance. The good predictive performance of …
-
Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… However, studies from our collaborators at MD Anderson Cancer Center show that hMSCs demonstrate variable tropism towards GSC-derived tumors (GSC xenografts; GSCXs). Those GSC xenografts that attract hMSCs are referred to as ‘attractors’, whereas those that fail to evoke hMSC homing are …
Page 1 of 2