Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"MCT4"”.
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Role of Monocarboxylate transporter in lung development and lung cancer
… family comprises 14 members however only MCT1-MCT4 are proton symporters that exhibit different affinities for lactate, leading to different levels of tissue expression. Ancillary protein, named CD147 is required to maintain the catalytic activity of and the translocation to the plasma membrane …
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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
… lactate monocarboxylate transporters MCT1 and MCT4. To investigate whether TMPRSS11B regulates lactate transport, we monitored intracellular lactate content and lactate secretion. Our data suggest TMPRSS11B regulates cellular lactate levels by interacting and co-localizing with Basigin and MCT4 …
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Investigating the metabolic impact of Metformin and Berberine in combination with Venetoclax for Acute Myeloid Leukaemia treatment
… reduced expression of the lactate efflux protein MCT4, whereas BBR+Ven increased MCT4 expression. Both combinations increased mitochondrial membrane permeability, correlating with increased cell death. Proteomic analysis of Met+Ven treated cells revealed decreased expression of core mitochondrial …
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Postmortem metabolism in porcine skeletal muscle
… activation of AMPK will have on MCT1, MCT2, and MCT4 expression in pigs. Compared to wild-type pigs, the longissimus lumborum of AMPK γ3R200Q pigs increased both MCT2 and MCT4 protein expression. Our data suggest glycolytic skeletal muscle from the AMPK γ3R200Q pigs has increased capacity for …
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Astrocyte metabolism following focal cerebral ischemia
… the brain are not known. We hypothesized that MCT4 is involved in the removal of lactate as this transporter isoform is responsible for lactate export from other tissues. Using immunogold cytochemistry, MCT4 was found to be densely expressed in the endfeet of glial cells facing blood …
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Ruolo del lattato e della proteina Insulin-Like Growth Factor Binding Protein 6 nel Glioblastoma Multiforme
… dall'espressione dei suoi trasportatori MCT1 e MCT4 e GRP81. I risultati sono stati convalidati in biopsie di GBM derivate dal paziente, confrontando l'espressione di MCT1 in campioni di GBM ad alto (H-) contro basso (L-) indice proliferativo (PI). Lo studio in vivo è stato condotto in un …