Global ETD Search
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Showing 1 to 4 of 4 for “"MCPH1"”.
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Function of MCPH1 in Neurogenesis
… während der Mitose. Darüber hinaus wurde für MCPH1, das von Microcephalin kodiert wird, eine Funktion in der DNA-Schadensantwort und Chromosomenkondensation gezeigt. Es ist jedoch nicht bekannt, welche Funktion von MCPH1 in der Gehirnentwicklung eine wichtige Rolle spielt. Ziel dieser Studie …
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Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… BRCT-repeat inhibitor of <em>hTERT </em>(BRIT1)/MCPH1 protein promotes the process of homologous recombination (HR) to repair DNA double strand breaks (DSBs). In response to DSBs, BRIT1 foci form at damaged sites, and recruits downstream repair proteins including 53BP1, MDC1, NBS1, and the …
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DNA damage responses in the context of the cell division cycle
… Chk1 phosphorylation and activation, and that MCPH1, a human homologue of Rad9, may share a conserved function in binding and activating Chk1, underscoring the evolutionarily conservation of checkpoint activation mechanisms.
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Identification of new functions for BRCT domains
… y-H2AX. In addition, the BRCT domains of MDC1, MCPH1 and BRCA1 bind to this y-H2AX-like peptide. We are interested in the role of PTIP in the DNA damage response, however, after encountering significant hurdles in generating PTIP knockdown cells, we decided to characterize the budding yeast PTIP …