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Showing 1 to 1 of 1 for “"MCOLN2/TRPML2"”.
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Natural Genetic Variants in Humans and Salmonellae Underlie Variable Infection Outcomes
… expression of the divalent cation channel gene MCOLN2. By deleting the MCOLN2 gene, I confirmed mucolipin-2 (MCOLN2 or TRPML2) is a host factor that reduces S. Typhi replication inside human immune cells. Further, MCOLN2-/- mice have increased Salmonella burden.</p><p>To determining how …