Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"MCMV"”.
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MCMV interferiert mit der MHC-Klasse-I-Antigenpräsentation
Das Zytomegalievirus der Maus (MCMV) zählt zur Familie der Herpesviridae und hat verschiedene Strategien entwickelt, um dem Immunsystem des Wirts zu entgehen. Einer dieser Mechanismen beeinflusst die Antigenpräsentation durch MHC-Klasse-I-Moleküle und wird durch das virale Genprodukt von m152 …
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Pathogenicity of Murine Cytomegalovirus Mutants
… identified nonessential murine cytomegalovirus (MCMV) genes involved in pathogenesis in vivo. Our approach to identifyjng these genes consisted of constructing MCMV mutants, and then analyzing these mutants in vitro and in vivo. Recombinant viruses (RV) expressing the β-glucuronidase marker gene …
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Die pathophysiologische Rolle der Infektion von sinusoidalen Endothelzellen der Leber mit murinem Zytomegalievirus
… (HCMV) und murines Zytomegalievirus (MCMV) sind DNA-Viren, die nach Primärinfektion lebenslang im infizierten Wirtsorganismus in einem latenten Zustand verbleiben können. In etwa 50-70% der Bevölkerung weltweit sind seropositiv für HCMV. Klinisch verläuft die Infektion mit HCMV für …
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Characterization of Murine Cytomegalovirus m142 and m143 Essential Gene Products
… and immunosuppressed patients. Murine CMV (MCMV) provides an opportunity to study the role of various viral products in replication and pathology in the natural host. Successful replication of CMV in the host depends upon the expression of a cascade of viral genes: immediate early (IE), …
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Infektion dendritischer Zellen mit murinem Zytomegalovirus
… für latente und lytische Infektionen durch MCMV und zur Untersuchung der Auswirkungen einer MCMV-Infektion auf den Phänotyp und die Funktion der Zellen wurde die murine hämatopoetische Stammzelllinie FDCP-Mix als Modellsystem verwendet. Definierte Differenzierungsstadien der Zellen entlang …
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Politica habitacional e urbanização: da reforma urbana ao Programa Minha Casa Minha Vida
… policy and guidelines of the My Home My Life (MCMV), created in 2009 by the Lula government, in order to reduce the housing deficit. Bringing a historical fight for Urban Reform in the country, its proposals and actions, and a summary of housing policy in Brazil, with the presentation of MCMV …
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Characterisation of open reading frames m29 and m29.1 in murine cytomegalovirus
Murine cytomegalovirus (MCMV) in its natural host, the mouse, is an excellent model for studying the biology of cytomegalovirus infection. Mostly this model has been used to study gene homologues of human cytomegalovirus (HCMV). Of the predicted 170 MCMV open reading frames (ORFs) only 78 have …
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Engineering resistance to maize lethal necrosis
… the interaction of Maize chlorotic mottle virus (MCMV) with any maize-infecting member of the potyviridae. I used next-generation RNA sequencing to characterise the MLN outbreak in East Africa, discovering that local and Chinese strains of the potyvirus Sugarcane mosaic virus (SCMV) typically …
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Murine Cytomegalovirus Encodes Proteins that Regulate Viral Late Transcription
… birth defects. Murine Cytomegalovirus (MCMV) is the primary surrogate model for HCMV, and resembles the human virus with respect to virion structure, genome organization, gene expression, tissue tropism, and clinical manifestations. In my graduate studies, I discovered the function of …
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Development of a conditionally-attenuated cytomegalovirus (CMV) vaccine vector platform, and initial investigations into use of CMV as a vaccine against pandemic influenza A virus
… and dose-dependent manner. Using the murine CMV (MCMV) system, we hypothesized that fusion of a DD to essential tegument proteins of MCMV would be capable of regulating the stability of the tegument proteins resulting in generation of conditionally-attenuated MCMV vectors. Part one of this thesis …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… (pARDS), γδ T cells in murine cytomegalovirus (MCMV), and multiple immune mediators and cell populations in adult severe influenza infection. Single-cell RNA sequencing of tracheal aspirate cells from pediatric subjects experiencing acute respiratory failure (ARF) showed that distinct T cell …
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Integrative analysis of transcriptional activity and genome architecture changes upon viral infections
… the entire kinetic of murine cytomegalovirus (mCMV) infection in mice. Host genome rearrangement is a well-known phenomenon of mCMV infection but the underlying mechanisms are largely unknown. Furthermore, HPV infection can lead to cervical cancers in humans, with genomic instability and …
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… expression. During NIH3T3 cell infection using MCMV-GFP, infected cells (GFP+) lost Clr-b expression, while uninfected ‘bystander’ cells (GFP–) upregulated Clr-b levels. This was due to reciprocal regulation of the Clec2d promoter and nascent transcripts in virus-infected versus bystander cells …
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Interactions Among Murine Cytomegalovirus US22 Family Gene Products That Influence Viral Pathogenesis
… of CMV infection. Previously three murine CMV (MCMV) genes (M139, M140, and M141) were identified to regulate viral expression in cultured macrophages and in mice. These genes are members of the US22 gene family with respect to HCMV homology. There is no function assigned to the proteins encoded …
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Die MHC-Klasse-I-regulatorische Funktion des 48 kDa Glykoproteins des murinen Cytomegalovirus
… 1997). In der vorliegenden Arbeit konnte das MCMV Glykoprotein gp48, welches durch das in der early Phase der Infektion exprimierte Gen m06 kodiert wird, als weiteres MHC-Klasse-I-reaktives Protein identifiziert werden. Zellen, die das Gen m06 stabil exprimieren, weisen eine stark verminderte …
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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection
… models of influenza and murine cytomegalovirus (MCMV) co-infection, we have found co-infection augments innate immunity and enhances functional CD8 T cell responses against influenza epitopes, but impairs MCMV-specific responses. These data suggest prior infection with herpesviruses are …
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Interdependent Regulation of Cytomegalovirus Proteins in Complex
… compromised. Using the mutine cytomegalovirus (MCMV) model, we identified two genes, M140 and M141, which are determinants of macrophage tropism. Monocytes/macrophages are a critical cell type for cytomegalovirus (CMV) pathogenesis as sites of viral latency and by supporting viral replication …
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IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
… activity, in a model of murine cytomegalovirus (MCMV) infection. Il1r8<sup>-/-</sup> mice showed an improved virus control in the liver and the protection was associated with enhanced NK cell degranulation and IFNγ production. The adoptive transfer of Il1r8<sup>-/-</sup> NK cells conferred …
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The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation
… of miR-155-/- NK cells were IFN-g+. In vivo MCMV-induced IFN-g expression by NK cells in these miR-155 models recapitulated the in vitro phenotypes. We performed unbiased RISC-Seq on WT and miR-155-/- NK cells, and found that mRNAs targeted by miR-155 were enriched in NK cell activation …
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Development, Security and Displacement: An Ethnographic Case Study of Rocinha and other Key Favelas in Rio de Janeiro
… for Accelerated Growth (PAC), My House, My Life (MCMV), and the internationally known <em>Bolsa Família</em>, or Family Grant.</p> <p>Meanwhile, Brazil and Rio de Janeiro’s pursuit to rebrand themselves as modern and developed through a series of mega sporting event capital of the world also …
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