Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 138 for “"MCL"”.
-
Differential Pax5 Levels Promote Mcl Dispersal and Progression and Predict A Poor Prognosis In Advanced Mcl Patients
… in the clinic including mantle cell lymphoma (MCL), which is one of the most aggressive B cell cancers. PAX5 levels in MCL patients were significantly repressed compared to normal B cells. Surprisingly, we found there were quantitative differences in PAX5 expression levels within MCL patient …
-
BAD and Mcl-1 Regulation in Prostate Cancer
… combination treatment causes a rapid decrease of Mcl-1 levels in androgen-independent C42 prostate cancer cells as well as other PTEN-deficient cancer cell lines. Based on this preliminary finding, we hypothesize that simultaneous BAD dephosphorylation and loss of Mcl-1 expression induce rapid …
-
Rapid turnover of McL-1 couples translation to cell survival and apoptosis
… role for the anti-apoptotic Bcl-2 family protein Mcl-1, which is rapidly lost following translation inhibition with a half-life of approximately 30 minutes, preceding Bak/Bax activation and detection of cell death. Overexpression of Mcl-1 abrogated cycloheximide-induced apoptosis, while knockdown …
-
Flexibility and specificity of the interaction of MCL-1 with BIM BH3
… proteins. I report X-ray crystal structures of MCL-1 in complex with peptides of wild-type and three point mutant sequences of BIM BH3. Together, these structures exhibit a range of conformations within the complex. Structural change with respect to wild-type is most dramatic for an …
-
Concomitant Inhibition of Flt3 and Mcl-1 In Flt3 Mutated Acute Myeloid Leukemia
<p>The MCL-1 inhibitor S63845 synergizes with the FLT3 inhibitor midostaurin for potent anti-leukemic effect in preclinical human models of FLT3-ITD mutated acute myeloid leukemia (AML). Acute Myeloid leukemia (AML) is a neoplastic blood disorder defined by a characteristically rapid growth rate …
-
The Role of MCL-1 in the Heart: Gateway from Life to Death
<p>MCL-1 is an essential BCL-2 family member that promotes the survival of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here, we have demonstrated that cardiac-specific ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy preceded by loss of …
-
Perbedaan kematangan emosi ditinjau dari jenis kelamin pada komunitas MCL (Malang Cat Lovers)
… emosinya. Di dalam fenomena komunitas MCL (Malang Cat Lovers) pada anggota laki – laki belum mampu untuk mengontrol emosinya, sedangkan anggota perempuan mampu untuk mengontrol atau mengendalikan emosinya. Dari sinilah melahirkan beberapa rumusan masalah, yaitu (1) Bagaimana kematangan …
-
Revealing a Non-canonical Role of Anti-apoptotic MCL-1 in Early Embryonic Development
<p>MCL-1, a well-known pro-survival BCL-2 family member, is indispensable for the survival of various cellular lineages and is also among the most frequently amplified genes in a variety of human malignancies. Gene ablation studies previously revealed that Mcl-1 deficiency leads to embryonic …
-
Anti-apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Couples Mitochondrial Fusion to Respiration
<p>MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of multiple cell lineages, is also among the most highly amplified genes in cancer. Although MCL-1 is known to oppose cell death, precisely how it functions to promote survival of normal and malignant cells is poorly …
-
Poles apart? : an intergenerational study of selected samples of postwar Polish immigrants in South Australia / by Roger McL. Harris
593 leaves : photos, tables, graphs ; 30 cm.
-
The Biology of Mantle Cell Lymphoma: Exploring the Gender Difference in Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is a rare B cell neoplasm that accounts for approximately 4-8% of non-Hodgkin’s lymphomas (NHLs). The median age at diagnosis is 65 years with a male to female predominance of 3:1. It has also been demonstrated that female MCL patients have a greater response to therapy, …
-
Targeted therapies in mantle cell lymphoma
Mantle cell lymphoma (MCL) is characterized by the presence of the t(11 ;14)(g13 ;g32) translocation which results in cyclin Dl over-expression. MCL is one of the most difficult lymphoproliferative disorders to manage with a median survival rate of 43 months from diagnosis. The poor prognosis …
-
The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
<p>Anti-apoptotic MCL1 is one of the most frequently amplified genes in human cancers and its elevated expression confers resistance to many therapeutics including the BH3-mimetic agents ABT-199 and ABT-263. The anti-malarial, dihydroartemisinin (DHA) translationally represses MCL-1 and synergizes …
-
Variation in thoracic wall thickness on multi-detector CT in adult patients and its implications in needle thoracostomy for tension pneumothorax
… space (ICS) in the midclavicular line (MCL). However, due to variations of chest wall thickness, the 50mm needle-mounted catheter is insufficient and may only reach the pleural space. Objectives: To investigate whether the recommended anatomical site and the length of the angiocatheter …
-
Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia
… Despite the initial success, we find that MCL-1 protein renders cancer cells resistant to ABT-199. Next we investigated whether p53 activation could overcome MCL-1–mediated resistance to BCL-2 inhibitor ABT-199. We demonstrate that p53 activation by MDM2 inhibitor RG7388 effectively …
-
Pim Kinase Inhibition: Single Agent and Combination Approaches In B-Cell Lymphoma
… and solid tumors.</p> <p>Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma. Elevated Pim kinase levels are common in MCL, and it negatively correlates with patient outcome. SGI-1776 is a small molecule inhibitor selective for Pim-1/-3. We hypothesize that SGI-1776 treatment in MCL will …
-
Exploring the role of IRF4 in the sensitivity of mantle cell lymphoma cells to Bruton's Tyrosine Kinase inhibitors
Introduction and aim: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell lymphoma. Therapy using Bruton’s tyrosine kinase (BTK) inhibitors has improved clinical outcomes but primary and secondary resistance to BTK inhibitor (BTKi) therapy affects more than half of MCL patients. …
-
Type I Insulin-Like Growth Factor Receptor Tyrosine Kinase As A Molecular Target In Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoid malignancy representing 5-10% of all non-Hodgkin’s lymphomas. It is distinguished by the t(11;14)(q13;q32) chromosomal translocation that juxtaposes the proto-oncogene CCND1, which encodes cyclin D1 at 11q13 to the IgH gene at 14q32. MCL …
Page 1 of 7