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Showing 1 to 20 of 20 for “"MCF7 breast cancer cells"”.
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Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells
Estrogen receptor (ER)-positive breast cancer is responsive to a number of targeted therapies used clinically. Unfortunately, the continuous application of any targeted therapy often results in resistance to the therapy. Our ultimate goal is to use mathematical modelling to optimize alternating …
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Effects of 5-fluorouracil Drug Treatment on the Expression Profile of MicroRNAs in MCF7 Breast Cancer Cells
Breast cancer is one of the leading causes of deaths in women worldwide. 5-flourouracil (5-FU) is a classic chemotherapeutic drug that has been widely used in the treatment of breast cancer patients. In this study, using several biochemical techniques, we studied the global effects of 5-FU …
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MT1-MMP enhances cell survival and proliferation via roles unrelated to metabolic transcript levels in MCF7 breast cancer cells
… is a multifunctional protease implicated in cancer aggressiveness for its ability to promote proliferation, migration, and invasion, particularly at low expression levels. Due to its multidomain structure and cell signalling abilities, MT1-MMP may act as a key regulatory node enhancing ATP …
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Altering the ADIPO: LEP Ratio Secreted by Obese Adipose Tissue affects the Tumor Growth Microenvironment of MCF7 Breast Cancer Cells
Breast cancer continues to be the number one cause of new cancer cases and second in mortality rate in Canadian women. For almost 50 years now researchers have shown a statistical link between obesity and breast cancer. Although adipose tissue in the past was considered an inert storage depot, we …
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In vitro studies of the effects of funfal-derived immunosuppressive agents on MCF7 breast cancer cells and Molt4 Leukaemia cells
… The molecular mechanism by which CsA on MCF-7 breast cancer and MOLT-4 human lymphoblastic T-cells were examined and results were compared to the effects of Mycophenolic acid (MPA) and Rapamycin (Rapa) in the search 6for new approaches that may explain controversy of these agents. CsA is a …
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Electrical stimulation effects on cell cycle and autophagy markers in MCF7 and MDA-MB-468 breast cancer cells
Breast cancer is a major health problem commonly seen in women. Despite considerable advancements in cancer research, cancer incidence continues to increase and cancer remains the second cause of death globally. It is crucial to further improve current cancer therapies and investigate novel …
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Chronic cadmium exposure alters ERα dependency and drug sensitivity of breast cancer cells
<p>The global prevalence of breast cancer in women illustrates the importance of identifying factors that contribute to disease onset and progression. Endogenous and environmental agents that interact with estrogen receptor alpha (ERα) have been shown to play a role in breast cancer etiology. …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
… hormone prolactin are associated with increased breast cancer risk and poor prognosis. Prolactin is also involved in breast cancer resistance to different chemotherapeutics. The overall goal of this project is to investigate potential pathways involved in prolactin induced resistance to DNA …
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Novel polyamine based anticancer agents: evaluation of the mode of action.
… via the major groove and have interesting anticancer properties prompting this study to evaluate their mode of action. All BNIPPs synthesised exert cytotoxicity in colon, breast and leukaemia cancer cell lines. The most active compound, BNIPSpd exhibits 24-hour IC50 values ranging from …
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The role of orphan nuclear receptor DAX-1 (NR0B1) in human breast cancer cells: expression, proliferation and metastasis
… be involved in several diseases including some cancers. Herein, we describe our examination of the role of DAX-1 in breast cancer, specifically its influence on proliferation and metastasis and its expression during progressive stages of disease. In an effort to understand how DAX-1 influences …
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URSOLIC ACID INHIBITED PROLIFERATION AND INVASION OF MDA-MB-231 HUMAN BREAST CANCER CELLS VIA REGULATING CELLULAR SIGNAL TRANSDUCTION PATHWAYS
Breast cancer is the most common cancer and the second leading cause of cancer death among American women. Increased intake of fruits and vegetables has been suggested to be one of major dietary factors reducing the risk of breast cancer. The health benefits were largely attributed to …
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
<p>Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotypic changes related to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to …
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Synthesis and biological evaluation of salicylaldimine complexes based on an alkylated PTA scaffold
Cancer remains one of the largest pandemics in the world, with millions affected by this disease every year. Since the discovery of the anticancer properties of cisplatin and other platinum-based drugs, metal-based chemotherapies have been extensively researched. Due to the elevated levels of …
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Curbing environmental pollution of water hyacinth by using it in drug discovery
… literature, however, the description of its anticancer mechanisms is limited and information on its potential for male contraceptive application is lacking.<br/><br/>This study set out to find alternative uses for water hyacinth by exploring gaps in drug discovery and the objective was to; (1) …
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Studien zur Regulation der Clusterin-Expression in der MCF-7- und MDA-MB-231-Mamma-Karzinom-Zelllinie
… is produced in inflamed epithelia and apoptotic cells and inhibits apoptotic cell death. In human breast carcinomas, sCLU overexpression is associated with tumor progression. To date, little is known about the hormonal regulation of clusterin expression in human breast cancer. Consequently, the …
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Suppression and activation of lipid signalling in cancer : tumour suppressor PTEN and oncogenic sphingosine kinase
… frequently mutated tumour suppressor gene in cancer. It is a lipid and protein phosphatase that negatively regulates the well-known pro-proliferative and anti-apoptotic phosphatidylinositol 3-kinase (PI3K)/AKT signalling pathway to modulate cell proliferation, cell cycle progression and cell …
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Small RNAs Regulate Transcription by Interacting with Noncoding RNA Transcripts
… 10 and 1000 fold lower than PR in T47D and MCF7 breast cancer cells. I have cloned three transcripts overlapping the promoter of PR from two cell lines – T47D and MCF7, each with unique splicing and transcription start sites. All of these transcripts initiate within the protein coding region …
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Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state
… lineage cell culture model for basal-like human breast cancer progression and in ERα-positive luminal MCF7 breast cancer cells. Low levels of ERα and ERβ mRNA were present in MCF10A-derived cell lines. SULT1E1 mRNA was more abundant in confluent relative to subconfluent MCF10A cells, a …
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
Extracellular vesicle (EV) release from tumour cells plays an important role in cancer drug resistance. It is essential that chemotherapeutic drugs are retained within target cells for increased efficacy in inducing apoptosis and as microvesiculation influences drug retention, this study has …