Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"MCF7"”.
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Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells
… over a 7-day time course in ER-positive MCF7 breast cancer cells. Treatments included endocrine therapy, either estrogen deprivation, which mimics the effects of an aromatase inhibitor, or fulvestrant, an ER degrader. These data were used to calibrate a mathematical model based on key …
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Mass Spectrometric Characterization of the MCF7 Cancer Cell Line: Proteome Profile and Cancer Biomarkers
… analysis of the proteomic constituents of the MCF7 breast cancer cell line using a shotgun 2-D strong cationic exchange/reversed phase liquid chromatography electrospray ionization tandem mass spectrometry (SCX/RP-LC-ESI-MS/MS) protocol. A series of optimization strategies were performed to …
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Effects of 5-fluorouracil Drug Treatment on the Expression Profile of MicroRNAs in MCF7 Breast Cancer Cells
… studied the global effects of 5-FU treatment on MCF7 breast cancer cells. The dose-response curve obtained after the treatment of MCF7 cells with 23 different 5-FU concentrations for 48 hours showed an atypical bimodal or biphasic curve, thus indicating a plausible dual mechanism of action for …
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Electrical stimulation effects on cell cycle and autophagy markers in MCF7 and MDA-MB-468 breast cancer cells
… myoblasts, cancerous rhabdomyosarcoma cells, and MCF7 breast cancer cells. EPS of MCF7 and MDA-MB-468 breast cancer cells revealed alterations in cellular signaling that suggest cell cycle arrest by autophagy. An Akt inhibitor was used to identify the role of Akt in the EPS response on breast …
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MT1-MMP enhances cell survival and proliferation via roles unrelated to metabolic transcript levels in MCF7 breast cancer cells
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a multifunctional protease implicated in cancer aggressiveness for its ability to promote proliferation, migration, and invasion, particularly at low expression levels. Due to its multidomain structure and cell signalling abilities, MT1-MMP may …
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Altering the ADIPO: LEP Ratio Secreted by Obese Adipose Tissue affects the Tumor Growth Microenvironment of MCF7 Breast Cancer Cells
… leads to varying degrees of cell cycle arrest in MCF7 breast cancer cells depending on diet, volume of physical activity and nutraceutical intervention. I show that regardless of menopausal status, the ADIPO:LEP ratio remained as a reliable and consistent predictor of the proliferative tumor …
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In vitro studies of the effects of funfal-derived immunosuppressive agents on MCF7 breast cancer cells and Molt4 Leukaemia cells
The therapeutic and aide effects of fungal-derived immunosuppressive drug such as Cyclosporin A (CsA) are still controversial, with the same amount of data published to date that states the beneficial effects of immunosupressants as well as their side effects. The molecular mechanism by which CsA …
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Identification of exosomal proteins in primary human bronchial tracheal epithelial cell HBTE and the H358, THP1 and MCF7 cell lines
… cancer H358, leukaemia THP1 and breast cancer MCF7) and a primary lung cell HBTE were isolated and their protein contents were analysed to establish whether cancer specific proteins are present. Methods and Materials: Exosomes were isolated and characterized by scanning (SEM) and transmission …
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Proteomic Investigation of Endocrine Therapy Resistance in Breast Cancer Investigating the Molecular Mechanisms for SERM Resistant Cell Lines Using SILAC-Based Proteomic Approach
… chemo-sensitivity (IC50) was determined for MCF7, T47D, MDA-MB-231, MDA-MB-468, MDA-MB-453, BT-20 and MCF-10A breast cell lines using four endocrine-based therapeutic agents (Tamoxifen, 4-Hydroxytamoxifen OHT, Raloxifene, Anastrozole) to select viable strains for resistance studies. MCF7 …
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Radiation-induced genomic instability and cellular communication: mechanistic investigations
… combinations were established between tumour (MCF7) and nontumour (HMT-3522S1) human breast epithelial cells using a 6-well plate co-culture system. The cells were irradiated with two doses of X-ray; 0.1 Gy (a iagnostic procedure relevant dose) and 2 Gy (therapeutic dose) and a sham-irradiation …
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
<p>Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotypic changes related to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to …
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Synthesis of Novel CYP1 Activated Heterocyclic Anticancer Prodrugs
… CYP1 expression. These were the MDA 468, MCF7 and MDA 231 cell lines. The non-tumour MCF10A cell line which has no basal CYP1 expression was used as the control. A library of eighteen 3,5-diarylpyrazoles were synthesised. The lead pyrazole DMU 10107 …
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RUOLO DELL'ISOFORMA A DEL RECETTORE INSULINICO E DEL SUO PARTNER MOLECOLARE DDR1 NEL CANCRO AL SENO
… generato delle cellule di cancro mammario umane MCF7 iperesprimenti IGF2. Inoltre abbiamo studiato l’effetto metabolico dell'IR-A infettando stabilmente le cellule MCF7 prive di IGF1R (MCF7 IGF1R-ve) con un cDNA di IR-A umano (MCF7 IGF1R-ve/IR-A). Abbiamo quindi valutato l'espressione di molecole …
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Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4-Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Production
… conjugate. We used stable transfection of V79 or MCF7 cell lines to generate transgenic model systems to compare protection across the different enzyme classes represented by ALDH3, GST 5.7, and AKR1C1. ALDH3 showed strong protection against HNE cytotoxicity, protein adduct formation, and GSH …
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THE ROLE OF RETROTRANSPOSITION AND EXOSOMAL DNA IN RADIATION-INDUCED GENOMIC INSTABILITY
… Three different cell lines (HF19, Caco-2, and MCF7) were used to investigate if clinically relevant doses of 0.1 Gy and 2 Gy X-rays activated LINE-1 retrotransposition, and if this caused an instability within the genome. 48 hours post exposure to 0.1 Gy X-rays the HF19 fibroblast cell line …
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Analysis of cellular responses to microwave irradiation in E. coli and change of oxygen level and culture medium in human cancer cell lines using RNA-seq based transcriptomic profiling
… conditions using breast cancer cell lines (MCF7) and prostate cancer cell lines (PC3) as the models. Our results in examining the gene expression change in E. coli showed that the non-thermal effects of MWI led to E. coli cells entering the stationary phase with most of the downregulated …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… (MDA-MB-231) and oestrogen receptor-positive (MCF7) breast cancer cell lines. Cytotoxicity assays were performed and BTC2 was shown to inhibit the proliferative rates of breast cancer cells with calculated IC50 values of 0.49μM in MCF7 cells and 0.58μM in MDA-MB-231 cells. BTC2 did not display …
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A Microsystems Approach for Drug Assessment
… different breast cancer cell lines namely LCC1/MCF7, LCC9/MCF7, MCF7, and MDA-MB231, and also to probe the effect of different drug treatments on the cells. These versatile platforms will enable the enhanced integration with other technologies and running multiple assays simultaneously. …
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